Allergen Delivery Inhibitors: A Rationale for Targeting Sentinel Innate Immune Signaling of Group 1 House Dust Mite Allergens through Structure-Based Protease Inhibitor Design

por Zhang, Jihui, Chen, Jie, Newton, Gary K., Perrior, Trevor R., Robinson, Clive
Publicado 2018

Allergen Delivery Inhibitors: Characterisation of Potent and Selective Inhibitors of Der p 1 and Their Attenuation of Airway Responses to House Dust Mite Allergens

por Zhang, Jihui, Chen, Jie, Zuo, Jie, Newton, Gary K., Stewart, Mark R., Perrior, Trevor R., Garrod, David R., Robinson, Clive
Publicado 2018

Clostridium difficile has a single sortase, SrtB, that can be inhibited by small-molecule inhibitors

por Donahue, Elizabeth H, Dawson, Lisa F, Valiente, Esmeralda, Firth-Clark, Stuart, Major, Meriel R, Littler, Eddy, Perrior, Trevor R, Wren, Brendan W
Publicado 2014

Selection and early clinical evaluation of the brain‐penetrant 11β‐hydroxysteroid dehydrogenase type 1 (11β‐HSD1) inhibitor UE2343 (Xanamem™)

por Webster, Scott P, McBride, Andrew, Binnie, Margaret, Sooy, Karen, Seckl, Jonathan R, Andrew, Ruth, Pallin, T David, Hunt, Hazel J, Perrior, Trevor R, Ruffles, Vincent S, Ketelbey, J William, Boyd, Alan, Walker, Brian R
Publicado 2017

The Discovery of Potent, Selective, and Reversible Inhibitors of the House Dust Mite Peptidase Allergen Der p 1: An Innovative Approach to the Treatment of Allergic Asthma

por Newton, Gary K., Perrior, Trevor R., Jenkins, Kerry, Major, Meriel R., Key, Rebekah E., Stewart, Mark R., Firth-Clark, Stuart, Lloyd, Steven M., Zhang, Jihui, Francis-Newton, Nicola J., Richardson, Jonathan P., Chen, Jie, Lai, Pei, Garrod, David R., Robinson, Clive
Publicado 2014

Targeting an Initiator Allergen Provides Durable and Expansive Protection against House Dust Mite Allergy

por Zhang, Jihui, Chen, Jie, Richardson, Jonathan P., Francis-Newton, Nicola-Jane, Lai, Pei F., Jenkins, Kerry, Major, Meriel R., Key, Rebekah E., Stewart, Mark E., Firth-Clark, Stuart, Lloyd, Steven M., Newton, Gary K., Perrior, Trevor R., Garrod, David R., Robinson, Clive
Publicado 2022