Abstract 1997: Assembling a structural model of the SARS-CoV-2 replication and transcription complex from 60+ subunits

por Perry, Jason
Publicado 2023

The Epc-N domain: a predicted protein-protein interaction domain found in select chromatin associated proteins

por Perry, Jason
Publicado 2006

Molecular Determinants of GS-9620-Dependent TLR7 Activation

por Rebbapragada, Indrani, Birkus, Gabriel, Perry, Jason, Xing, Weimei, Kwon, HyockJoo, Pflanz, Stefan
Publicado 2016

1646. Combined Resistance Analyses From Phase 2b Studies of Presatovir Treatment in RSV-Infected Adults

por Porter, Danielle, Guo, Ying, Perry, Jason, Gossage, David, Watkins, Timothy, Chien, Jason, Jordan, Robert
Publicado 2018

Genetic conservation of SARS-CoV-2 RNA replication complex in globally circulating isolates and recently emerged variants from humans and minks suggests minimal pre-existing resist...

por Martin, Ross, Li, Jiani, Parvangada, Aiyappa, Perry, Jason, Cihlar, Tomas, Mo, Hongmei, Porter, Danielle, Svarovskaia, Evguenia
Publicado 2021

An atomistic model of the coronavirus replication-transcription complex as a hexamer assembled around nsp15

por Perry, Jason K., Appleby, Todd C., Bilello, John P., Feng, Joy Y., Schmitz, Uli, Campbell, Elizabeth A.
Publicado 2021

Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency

por Gordon, Calvin J., Tchesnokov, Egor P., Woolner, Emma, Perry, Jason K., Feng, Joy Y., Porter, Danielle P., Götte, Matthias
Publicado 2020

506. Resistance Analyses from the Remdesivir Phase 3 REDPINE Study in Participants with Severely Reduced Kidney Function Who Were Hospitalized for COVID-19

por Andreatta, Kristen, Li, Jiani, Rodriguez, Lauren, Han, Dong, Xu, Simin, Perry, Jason K, Koullias, Yiannis, Hyland, Robert H, Hedskog, Charlotte
Publicado 2023

545. Remdesivir And Obeldesivir Retain Potent Activity Against SARS-CoV-2 Omicron Variants

por Rodriguez, Lauren, Li, Jiani, Han, Dong, Martin, Ross, Moshiri, Jasmine, Peinovich, Nadine, Bilello, John P, Perry, Jason K, Hedskog, Charlotte
Publicado 2023

Template-dependent inhibition of coronavirus RNA-dependent RNA polymerase by remdesivir reveals a second mechanism of action

por Tchesnokov, Egor P., Gordon, Calvin J., Woolner, Emma, Kocinkova, Dana, Perry, Jason K., Feng, Joy Y., Porter, Danielle P., Götte, Matthias
Publicado 2020

Correction: Template-dependent inhibition of coronavirus RNA-dependent RNA polymerase by remdesivir reveals a second mechanism of action

por Tchesnokov, Egor P., Gordon, Calvin J., Woolner, Emma, Kocincova, Dana, Perry, Jason K., Feng, Joy Y., Porter, Danielle P., Götte, Matthias
Publicado 2021

Efficient incorporation and template-dependent polymerase inhibition are major determinants for the broad-spectrum antiviral activity of remdesivir

por Gordon, Calvin J., Lee, Hery W., Tchesnokov, Egor P., Perry, Jason K., Feng, Joy Y., Bilello, John P., Porter, Danielle P., Götte, Matthias
Publicado 2021

In Vitro Selection of Remdesivir-Resistant SARS-CoV-2 Demonstrates High Barrier to Resistance

por Checkmahomed, Liva, Carbonneau, Julie, Du Pont, Venice, Riola, Nicholas C., Perry, Jason K., Li, Jiani, Paré, Bastien, Simpson, Shawn M., Smith, Martin A., Porter, Danielle P., Boivin, Guy
Publicado 2022

Structural and Regulatory Elements of HCV NS5B Polymerase – β-Loop and C-Terminal Tail – Are Required for Activity of Allosteric Thumb Site II Inhibitors

por Boyce, Sarah E., Tirunagari, Neeraj, Niedziela-Majka, Anita, Perry, Jason, Wong, Melanie, Kan, Elaine, Lagpacan, Leanna, Barauskas, Ona, Hung, Magdeleine, Fenaux, Martijn, Appleby, Todd, Watkins, William J., Schmitz, Uli, Sakowicz, Roman
Publicado 2014

Role of Mitochondrial RNA Polymerase in the Toxicity of Nucleotide Inhibitors of Hepatitis C Virus

por Feng, Joy Y., Xu, Yili, Barauskas, Ona, Perry, Jason K., Ahmadyar, Shekeba, Stepan, George, Yu, Helen, Babusis, Darius, Park, Yeojin, McCutcheon, Krista, Perron, Michel, Schultz, Brian E., Sakowicz, Roman, Ray, Adrian S.
Publicado 2016

A New Natural Defense Against Airborne Pathogens

por Edwards, David, Hickey, Anthony, Batycky, Richard, Griel, Lester, Lipp, Michael, Dehaan, Wes, Clarke, Robert, Hava, David, Perry, Jason, Laurenzi, Brendan, Curran, Aidan K., Beddingfield, Brandon J., Roy, Chad J., Devlin, Tom, Langer, Robert
Publicado 2020

Viral Resistance Analyses From the Remdesivir Phase 3 Adaptive COVID-19 Treatment Trial-1 (ACTT-1)

por Hedskog, Charlotte, Rodriguez, Lauren, Roychoudhury, Pavitra, Huang, Meei-Li, Jerome, Keith R, Hao, Linhui, Ireton, Renee C, Li, Jiani, Perry, Jason K, Han, Dong, Camus, Gregory, Greninger, Alexander L, Gale, Michael, Porter, Danielle P
Publicado 2023

The Nucleoside/Nucleotide Analogs Tenofovir and Emtricitabine Are Inactive against SARS-CoV-2

por Feng, Joy Y., Du Pont, Venice, Babusis, Darius, Gordon, Calvin J., Tchesnokov, Egor P., Perry, Jason K., Duong, Vincent, Vijjapurapu, Arya, Zhao, Xiaofeng, Chan, Julie, Cohen, Cal, Juneja, Kavita, Cihlar, Tomas, Götte, Matthias, Bilello, John P.
Publicado 2022

1149. Resistance Analyses of Patient Viral Samples from the Remdesivir Phase 3 Adaptive COVID-19 Treatment Trial-1 (ACTT-1)

por Hedskog, Charlotte, Rodriguez, Lauren, Beigel, John H, Dempsey, Walla, Greninger, Alexander L, Roychoudhury, Pavitra, Huang, Meei-Li, Jerome, Keith R, Hao, Linhui, Ireton, Renee, Gale, Michael, Li, Jiani, Perry, Jason, Han, Dong, Camus, Gregory, Porter, Danielle P
Publicado 2022

Remdesivir and GS-441524 Retain Antiviral Activity against Delta, Omicron, and Other Emergent SARS-CoV-2 Variants

por Pitts, Jared, Li, Jiani, Perry, Jason K., Du Pont, Venice, Riola, Nicholas, Rodriguez, Lauren, Lu, Xianghan, Kurhade, Chaitanya, Xie, Xuping, Camus, Gregory, Manhas, Savrina, Martin, Ross, Shi, Pei-Yong, Cihlar, Tomas, Porter, Danielle P., Mo, Hongmei, Maiorova, Evguenia, Bilello, John P.
Publicado 2022