Applications of Model-Based Meta-Analysis in Drug Development

por Chan, Phyllis, Peskov, Kirill, Song, Xuyang
Publicado 2022

Interpretation of metabolic memory phenomenon using a physiological systems model: What drives oxidative stress following glucose normalization?

por Voronova, Veronika, Zhudenkov, Kirill, Helmlinger, Gabriel, Peskov, Kirill
Publicado 2017

Role of T Cell-To-Dendritic Cell Chemoattraction in T Cell Priming Initiation in the Lymph Node: An Agent-Based Modeling Study

por Azarov, Ivan, Peskov, Kirill, Helmlinger, Gabriel, Kosinsky, Yuri
Publicado 2019

Cycle Network Model of Prostaglandin H Synthase-1

por Goltsov, Alexey, Swat, Maciej, Peskov, Kirill, Kosinsky, Yuri
Publicado 2020

Quantification of Scheduling Impact on Safety and Efficacy Outcomes of Brain Metastasis Radio- and Immuno-Therapies: A Systematic Review and Meta-Analysis

por Voronova, Veronika, Lebedeva, Svetlana, Sekacheva, Marina, Helmlinger, Gabriel, Peskov, Kirill
Publicado 2020

Semi-Mechanistic Pharmacokinetic-Pharmacodynamic Model of Camostat Mesylate-Predicted Efficacy against SARS-CoV-2 in COVID-19

por Kosinsky, Yuri, Peskov, Kirill, Stanski, Donald R., Wetmore, Diana, Vinetz, Joseph
Publicado 2022

Quantitative Mechanistic Modeling in Support of Pharmacological Therapeutics Development in Immuno-Oncology

por Peskov, Kirill, Azarov, Ivan, Chu, Lulu, Voronova, Veronika, Kosinsky, Yuri, Helmlinger, Gabriel
Publicado 2019

Longitudinal Tumor Size and Neutrophil‐to‐Lymphocyte Ratio Are Prognostic Biomarkers for Overall Survival in Patients With Advanced Non‐Small Cell Lung Cancer Treated With Durvalum...

por Gavrilov, Sergey, Zhudenkov, Kirill, Helmlinger, Gabriel, Dunyak, James, Peskov, Kirill, Aksenov, Sergey
Publicado 2020

A workflow for the joint modeling of longitudinal and event data in the development of therapeutics: Tools, statistical methods, and diagnostics

por Zhudenkov, Kirill, Gavrilov, Sergey, Sofronova, Alina, Stepanov, Oleg, Kudryashova, Nataliya, Helmlinger, Gabriel, Peskov, Kirill
Publicado 2022

DBSolve Optimum: a software package for kinetic modeling which allows dynamic visualization of simulation results

por Gizzatkulov, Nail M, Goryanin, Igor I, Metelkin, Eugeny A, Mogilevskaya, Ekaterina A, Peskov, Kirill V, Demin, Oleg V
Publicado 2010

Longitudinal FEV(1) and Exacerbation Risk in COPD: Quantifying the Association Using Joint Modelling

por Zhudenkov, Kirill, Palmér, Robert, Jauhiainen, Alexandra, Helmlinger, Gabriel, Stepanov, Oleg, Peskov, Kirill, Eriksson, Ulf G, Wählby Hamrén, Ulrika
Publicado 2021

Combination of immune checkpoint inhibitors with radiation therapy in cancer: A hammer breaking the wall of resistance

por Voronova, Veronika, Vislobokova, Anastasia, Mutig, Kerim, Samsonov, Mikhail, Peskov, Kirill, Sekacheva, Marina, Materenchuk, Maria, Bunyatyan, Natalya, Lebedeva, Svetlana
Publicado 2022

A Physiology-Based Model of Bile Acid Distribution and Metabolism Under Healthy and Pathologic Conditions in Human Beings

por Voronova, Veronika, Sokolov, Victor, Al-Khaifi, Amani, Straniero, Sara, Kumar, Chanchal, Peskov, Kirill, Helmlinger, Gabriel, Rudling, Mats, Angelin, Bo
Publicado 2020

Agent Based Modeling of Human Gut Microbiome Interactions and Perturbations

por Shashkova, Tatiana, Popenko, Anna, Tyakht, Alexander, Peskov, Kirill, Kosinsky, Yuri, Bogolubsky, Lev, Raigorodskii, Andrei, Ischenko, Dmitry, Alexeev, Dmitry, Govorun, Vadim
Publicado 2016

Comparative quantitative systems pharmacology modeling of anti-PCSK9 therapeutic modalities in hypercholesterolemia

por Sokolov, Victor, Helmlinger, Gabriel, Nilsson, Catarina, Zhudenkov, Kirill, Skrtic, Stanko, Hamrén, Bengt, Peskov, Kirill, Hurt-Camejo, Eva, Jansson-Löfmark, Rasmus
Publicado 2019

Radiation and PD-(L)1 treatment combinations: immune response and dose optimization via a predictive systems model

por Kosinsky, Yuri, Dovedi, Simon J., Peskov, Kirill, Voronova, Veronika, Chu, Lulu, Tomkinson, Helen, Al-Huniti, Nidal, Stanski, Donald R., Helmlinger, Gabriel
Publicado 2018

Evaluation of therapeutic strategies targeting BCAA catabolism using a systems pharmacology model

por Voronova, Veronika, Sokolov, Victor, Morias, Yannick, Boezelman, Malin Jonsson, Wågberg, Maria, Henricsson, Marcus, Hansson, Karl, Goltsov, Alexey, Peskov, Kirill, Sundqvist, Monika
Publicado 2022

Differentiating the Sodium‐Glucose Cotransporter 1 Inhibition Capacity of Canagliflozin vs. Dapagliflozin and Empagliflozin Using Quantitative Systems Pharmacology Modeling

por Sokolov, Victor, Yakovleva, Tatiana, Chu, Lulu, Tang, Weifeng, Greasley, Peter J., Johansson, Susanne, Peskov, Kirill, Helmlinger, Gabriel, Boulton, David W., Penland, Robert C.
Publicado 2020

Dose dependence of treatment-related adverse events for immune checkpoint inhibitor therapies: a model-based meta-analysis

por Shulgin, Boris, Kosinsky, Yuri, Omelchenko, Andrey, Chu, Lulu, Mugundu, Ganesh, Aksenov, Sergey, Pimentel, Rodrigo, DeYulia, Garrett, Kim, Geoffrey, Peskov, Kirill, Helmlinger, Gabriel
Publicado 2020

Evaluation of Combination Strategies for the A(2A)R Inhibitor AZD4635 Across Tumor Microenvironment Conditions via a Systems Pharmacology Model

por Voronova, Veronika, Peskov, Kirill, Kosinsky, Yuri, Helmlinger, Gabriel, Chu, Lulu, Borodovsky, Alexandra, Woessner, Richard, Sachsenmeier, Kris, Shao, Wenlin, Kumar, Rakesh, Pouliot, Gayle, Merchant, Melinda, Kimko, Holly, Mugundu, Ganesh
Publicado 2021