Druggable Lipid Binding Sites in Pentameric Ligand-Gated Ion Channels and Transient Receptor Potential Channels

por Cheng, Wayland W. L., Arcario, Mark J., Petroff, John T.
Publicado 2022

Direct binding of phosphatidylglycerol at specific sites modulates desensitization of a ligand-gated ion channel

por Tong, Ailing, Petroff, John T, Hsu, Fong-Fu, Schmidpeter, Philipp AM, Nimigean, Crina M, Sharp, Liam, Brannigan, Grace, Cheng, Wayland WL
Publicado 2019

Photo-oxidation and Thermal Oxidations of Triptycene Thiols by Aryl Chalcogen Oxides

por Chintala, Satyanarayana M., Maness, Peter F., Petroff, John T., Throgmorton, John C., Zhang, Miao, Omlid, Sara M., McCulla, Ryan D.
Publicado 2020

Membrane phospholipids control gating of the mechanosensitive potassium leak channel TREK1

por Schmidpeter, Philipp A. M., Petroff, John T., Khajoueinejad, Leila, Wague, Aboubacar, Frankfater, Cheryl, Cheng, Wayland W. L., Nimigean, Crina M., Riegelhaupt, Paul M.
Publicado 2023

Polyunsaturated fatty acids inhibit a pentameric ligand-gated ion channel through one of two binding sites

por Dietzen, Noah M, Arcario, Mark J, Chen, Lawrence J, Petroff, John T, Moreland, K Trent, Krishnan, Kathiresan, Brannigan, Grace, Covey, Douglas F, Cheng, Wayland WL
Publicado 2022

In vitro oxidations of low-density lipoprotein and RAW 264.7 cells with lipophilic O((3)P)-precursors

por Petroff, John T., Isor, Ankita, Chintala, Satyanarayana M., Albert, Carolyn J., Franke, Jacob D., Weinstein, David, Omlid, Sara M., Arnatt, Christopher K., Ford, David A., McCulla, Ryan D.
Publicado 2020

Open-channel structure of a pentameric ligand-gated ion channel reveals a mechanism of leaflet-specific phospholipid modulation

por Petroff, John T., Dietzen, Noah M., Santiago-McRae, Ezry, Deng, Brett, Washington, Maya S., Chen, Lawrence J., Trent Moreland, K., Deng, Zengqin, Rau, Michael, Fitzpatrick, James A. J., Yuan, Peng, Joseph, Thomas T., Hénin, Jérôme, Brannigan, Grace, Cheng, Wayland W. L.
Publicado 2022