RARE-12. Pineoblastoma of children and young adults in a national population: An analysis of the HIT-MED study cohort

por Yuan, Mathias, Mynarek, Martin, Goschzik, Tobias, Pfaff, Elke, Kortmann, Rolf, Bison, Brigitte, Warmuth-Metz, Monika, Schiller, Ulrich, Hagel, Christian, Obrecht, Denise, Benesch, Martin, Pfister, Stefan M, Pietsch, Torsten, Rutkowski, Stefan
Publicado 2022

ETMR-14. The single-cell landscape of pineoblastoma identifies developmental origins and exposes novel therapeutic vulnerabilities.

por Gudenas, Brian, Englinger, Bernhard, Liu, Anthony P Y, Ahmad, Sheikh Tanveer, Meredith, David, Pfaff, Elke, Paul, Leena, Hadley, Jennifer, Batts, Melissa, Klimo, Paul, Boop, Frederick A, Gajjar, Amar, Robinson, Giles, Orr, Brent, Lin, Hong, Alexandrescu, Sanda, Jones, David T W, Filbin, Mariella G, Northcott, Paul A
Publicado 2022

ATRT-08. THE SINGLE-CELL LANDSCAPE OF PINEOBLASTOMA IDENTIFIES DEVELOPMENTAL ORIGINS AND EXPOSES TUMORIGENIC DEPENDENCIES

por Gudenas, Brian, Englinger, Bernhard, Liu, Anthony P Y, Ahmad, Sheikh Tanveer, Meredith, David, Pfaff, Elke, Paul, Leena, Hadley, Jennifer, Batts, Melissa, Klimo Jr., Paul, Boop, Frederick A, Gajjar, Amar, Robinson, Giles W, Orr, Brent A, Lin, Hong, Alexandrescu, Sanda, Jones, David T W, Filbin, Mariella G, Northcott, Paul A
Publicado 2023

INFORM2 NivEnt: The first trial of the INFORM2 biomarker driven phase I/II trial series: the combination of nivolumab and entinostat in children and adolescents with refractory hig...

por van Tilburg, Cornelis M., Witt, Ruth, Heiss, Melanie, Pajtler, Kristian W., Plass, Christoph, Poschke, Isabel, Platten, Michael, Harting, Inga, Sedlaczek, Oliver, Freitag, Angelika, Meyrath, David, Taylor, Lenka, Balasubramanian, Gnana Prakash, Jäger, Natalie, Pfaff, Elke, Jones, Barbara C., Milde, Till, Pfister, Stefan M., Jones, David T. W., Kopp-Schneider, Annette, Witt, Olaf
Publicado 2020

Genomic characterization of DICER1-associated neoplasms uncovers molecular classes

por Kommoss, Felix K. F., Chong, Anne-Sophie, Chong, Anne-Laure, Pfaff, Elke, Jones, David T. W., Hiemcke-Jiwa, Laura S., Kester, Lennart A., Flucke, Uta, Gessler, Manfred, Schrimpf, Daniel, Sahm, Felix, Clarke, Blaise A., Stewart, Colin J. R., Wang, Yemin, Gilks, C. Blake, Kommoss, Friedrich, Huntsman, David G., Schüller, Ulrich, Koelsche, Christian, McCluggage, W. Glenn, von Deimling, Andreas, Foulkes, William D.
Publicado 2023

UV-radiation and MC1R germline mutations are risk factors for the development of conventional and spitzoid melanomas in children and adolescents

por Liebmann, Alexandra, Admard, Jakob, Armeanu-Ebinger, Sorin, Wild, Hannah, Abele, Michael, Gschwind, Axel, Seibel-Kelemen, Olga, Seitz, Christian, Bonzheim, Irina, Riess, Olaf, Demidov, German, Sturm, Marc, Schadeck, Malou, Pogoda, Michaela, Bien, Ewa, Krawczyk, Malgorzata, Jüttner, Eva, Mentzel, Thomas, Cesen, Maja, Pfaff, Elke, Kunc, Michal, Forchhammer, Stephan, Forschner, Andrea, Leiter-Stöppke, Ulrike, Eigentler, Thomas K., Schneider, Dominik T., Schroeder, Christopher, Ossowski, Stephan, Brecht, Ines B.
Publicado 2023

ETMR-21. META-ANALYSIS OF PINEAL REGION TUMOURS DEMONSTRATES MOLECULAR SUBGROUPS WITH DISTINCT CLINICO-PATHOLOGICAL FEATURES: A CONSENSUS STUDY

por Li, Bryan K, Liu, Anthony P Y, Pfaff, Elke, Gudenas, Brian, Gershanov, Sivan, Dufour, Christelle, Aichmüller, Christian, Sill, Martin, Lin, Tong, Onar-Thomas, Arzu, Orr, Brent A, Hawkins, Cynthia, Ellison, David W, Snuderl, Matija, Laquierre, Annie, Hwang, Eugene, Gururangan, Sri, Karajannis, Matthias A, Robinson, Giles W, Bouffet, Eric, Vasiljevic, Alexandre, Gajjar, Amar, Pfister, Stefan M, Northcott, Paul A, Jones, David T W, Huang, Annie
Publicado 2020

Genetical and epigenetical profiling identifies two subgroups of pineal parenchymal tumors of intermediate differentiation (PPTID) with distinct molecular, histological and clinica...

por Rahmanzade, Ramin, Pfaff, Elke, Banan, Rouzbeh, Sievers, Philipp, Suwala, Abigail K., Hinz, Felix, Bogumil, Henri, Cherkezov, Asan, Kaan, Aras Fuat, Schrimpf, Daniel, Friedel, Dennis, Göbel, Kirsten, Keller, Felix, Saenz-Sardà, Xavier, Lossos, Alexander, Sill, Martin, Witt, Olaf, Sakowitz, Oliver W., Korshunov, Andrey, Reuss, David E., Etminan, Nima, Unterberg, Andreas, Ratliff, Miriam, Herold-Mende, Christel, Wick, Wolfgang, Pfister, Stefan M., von Deimling, Andreas, Jones, David T. W., Sahm, Felix
Publicado 2023

Alternative lengthening of telomeres in childhood neuroblastoma from genome to proteome

por Hartlieb, Sabine A., Sieverling, Lina, Nadler-Holly, Michal, Ziehm, Matthias, Toprak, Umut H., Herrmann, Carl, Ishaque, Naveed, Okonechnikov, Konstantin, Gartlgruber, Moritz, Park, Young-Gyu, Wecht, Elisa Maria, Savelyeva, Larissa, Henrich, Kai-Oliver, Rosswog, Carolina, Fischer, Matthias, Hero, Barbara, Jones, David T. W., Pfaff, Elke, Witt, Olaf, Pfister, Stefan M., Volckmann, Richard, Koster, Jan, Kiesel, Katharina, Rippe, Karsten, Taschner-Mandl, Sabine, Ambros, Peter, Brors, Benedikt, Selbach, Matthias, Feuerbach, Lars, Westermann, Frank
Publicado 2021

Radiation-induced gliomas represent H3-/IDH-wild type pediatric gliomas with recurrent PDGFRA amplification and loss of CDKN2A/B

por Deng, Maximilian Y., Sturm, Dominik, Pfaff, Elke, Sill, Martin, Stichel, Damian, Balasubramanian, Gnana Prakash, Tippelt, Stephan, Kramm, Christof, Donson, Andrew M., Green, Adam L., Jones, Chris, Schittenhelm, Jens, Ebinger, Martin, Schuhmann, Martin U., Jones, Barbara C., van Tilburg, Cornelis M., Wittmann, Andrea, Golanov, Andrey, Ryzhova, Marina, Ecker, Jonas, Milde, Till, Witt, Olaf, Sahm, Felix, Reuss, David, Sumerauer, David, Zamecnik, Josef, Korshunov, Andrey, von Deimling, Andreas, Pfister, Stefan M., Jones, David T. W.
Publicado 2021

Recurrent homozygous deletion of DROSHA and microduplication of PDE4DIP in pineoblastoma

por Snuderl, Matija, Kannan, Kasthuri, Pfaff, Elke, Wang, Shiyang, Stafford, James M., Serrano, Jonathan, Heguy, Adriana, Ray, Karina, Faustin, Arline, Aminova, Olga, Dolgalev, Igor, Stapleton, Stacie L., Zagzag, David, Chiriboga, Luis, Gardner, Sharon L., Wisoff, Jeffrey H., Golfinos, John G., Capper, David, Hovestadt, Volker, Rosenblum, Marc K., Placantonakis, Dimitris G., LeBoeuf, Sarah E., Papagiannakopoulos, Thales Y., Chavez, Lukas, Ahsan, Sama, Eberhart, Charles G., Pfister, Stefan M., Jones, David T. W., Karajannis, Matthias A.
Publicado 2018

ETMR-06. DISSECTING THE MOLECULAR AND DEVELOPMENTAL BASIS OF PINEOBLASTOMA THROUGH GENOMICS

por Gudenas, Brian, Englinger, Bernhard, Liu, Anthony P Y, Tong, Yiai, Meredith, David, Pfaff, Elke, Lin, Tong, Orr, Brent A, Klimo, Paul, Bihannic, Laure, Paul, Leena, Kumar, Rahul, Bouffet, Eric, Gururangan, Sridharan, Crawford, John R, Kellie, Stewart J, Chintagumpala, Murali, Fisher, Michael J, Bowers, Daniel C, Hassall, Tim, Indelicato, Daniel J, Ellison, David W, Boop, Frederick A, Merchant, Thomas E, Chiang, Jason, Robinson, Giles W, Gajjar, Amar, Alexandrescu, Sanda, Jones, David T W, Filbin, Mariella G, Northcott, Paul A
Publicado 2020

WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma

por Zhukova, Nataliya, Ramaswamy, Vijay, Remke, Marc, Martin, Dianna C, Castelo-Branco, Pedro, Zhang, Cindy H, Fraser, Michael, Tse, Ken, Poon, Raymond, Shih, David JH, Baskin, Berivan, Ray, Peter N, Bouffet, Eric, Dirks, Peter, von Bueren, Andre O, Pfaff, Elke, Korshunov, Andrey, Jones, David TW, Northcott, Paul A, Kool, Marcel, Pugh, Trevor J, Pomeroy, Scott L, Cho, Yoon-Jae, Pietsch, Torsten, Gessi, Marco, Rutkowski, Stefan, Bognár, Laszlo, Cho, Byung-Kyu, Eberhart, Charles G, Conter, Cecile Faure, Fouladi, Maryam, French, Pim J, Grajkowska, Wieslawa A, Gupta, Nalin, Hauser, Peter, Jabado, Nada, Vasiljevic, Alexandre, Jung, Shin, Kim, Seung-Ki, Klekner, Almos, Kumabe, Toshihiro, Lach, Boleslaw, Leonard, Jeffrey R, Liau, Linda M, Massimi, Luca, Pollack, Ian F, Ra, Young Shin, Rubin, Joshua B, Van Meir, Erwin G, Wang, Kyu-Chang, Weiss, William A, Zitterbart, Karel, Bristow, Robert G, Alman, Benjamin, Hawkins, Cynthia E, Malkin, David, Clifford, Steven C, Pfister, Stefan M, Taylor, Michael D, Tabori, Uri
Publicado 2014

The Pediatric Precision Oncology INFORM Registry: Clinical Outcome and Benefit for Patients with Very High-Evidence Targets

por van Tilburg, Cornelis M., Pfaff, Elke, Pajtler, Kristian W., Langenberg, Karin P.S., Fiesel, Petra, Jones, Barbara C., Balasubramanian, Gnana Prakash, Stark, Sebastian, Johann, Pascal D., Blattner-Johnson, Mirjam, Schramm, Kathrin, Dikow, Nicola, Hirsch, Steffen, Sutter, Christian, Grund, Kerstin, von Stackelberg, Arend, Kulozik, Andreas E., Lissat, Andrej, Borkhardt, Arndt, Meisel, Roland, Reinhardt, Dirk, Klusmann, Jan-Henning, Fleischhack, Gudrun, Tippelt, Stephan, von Schweinitz, Dietrich, Schmid, Irene, Kramm, Christof M., von Bueren, André O., Calaminus, Gabriele, Vorwerk, Peter, Graf, Norbert, Westermann, Frank, Fischer, Matthias, Eggert, Angelika, Burkhardt, Birgit, Wößmann, Wilhelm, Nathrath, Michaela, Hecker-Nolting, Stefanie, Frühwald, Michael C., Schneider, Dominik T., Brecht, Ines B., Ketteler, Petra, Fulda, Simone, Koscielniak, Ewa, Meister, Michael T., Scheer, Monika, Hettmer, Simone, Schwab, Matthias, Tremmel, Roman, Øra, Ingrid, Hutter, Caroline, Gerber, Nicolas U., Lohi, Olli, Kazanowska, Bernarda, Kattamis, Antonis, Filippidou, Maria, Goemans, Bianca, Zwaan, C. Michel, Milde, Till, Jäger, Natalie, Wolf, Stephan, Reuss, David, Sahm, Felix, von Deimling, Andreas, Dirksen, Uta, Freitag, Angelika, Witt, Ruth, Lichter, Peter, Kopp-Schneider, Annette, Jones, David T.W., Molenaar, Jan J., Capper, David, Pfister, Stefan M., Witt, Olaf
Publicado 2021

HGG-11. Clinical characteristics and clinical evolution of a large cohort of pediatric patients with primary central nervous system (CNS) tumors and tropomyosin receptor kinase (TR...

por Lamoureux, Audrey-Anne, Fisher, Michael, Lemelle, Lauriane, Pfaff, Elke, Kramm, Christof, De Wilde, Bram, Kazanowska, Bernarda, Hutter, Caroline, Pfister, Stefan M, Sturm, Dominik, Jones, David, Orbach, Daniel, Pierron, Gaëlle, Raskin, Scott, Drilon, Alexander, Diamond, Eli, Harada, Guilherme, Zapotocky, Michal, Ellezam, Benjamin, Weil, Alexander G, Venne, Dominic, Barritault, Marc, Leblond, Pierre, Coltin, Hallie, Hammad, Rawan, Tabori, Uri, Hawkins, Cynthia, Hansford, Jordan R, Meyran, Deborah, Erker, Craig, McFadden, Kathryn, Sato, Mariko, Gottardo, Nicholas G, Dholaria, Hetal, Nørøxe, Dorte Schou, Goto, Hiroaki, Ziegler, David S, Lin, Frank Y, Parsons, Donald Williams, Lindsay, Holly, Wong, Tai-Tong, Liu, Yen-Lin, Wu, Kuo-Sheng, Franson, Andrea Flynn, Hwang, Eugene, Aguilar-Bonilla, Ana, Cheng, Sylvia, Cacciotti, Chantel, Massimino, Maura, Schiavello, Elisabetta, Wood, Paul, Hoffman, Lindsey M, Cappellano, Andréa, Lassaletta, Alvaro, Van Damme, An, Llort, Anna, Gerber, Nicolas U, Ceruso, Mariella Spalato, Bendel, Anne E, Skrypek, Maggie, Hamideh, Dima, Mushtaq, Naureen, Walter, Andrew, Jabado, Nada, Alsahlawi, Aysha, Farmer, Jean-Pierre, Abadi, Christina Coleman, Mueller, Sabine, Mazewski, Claire, Aguilera, Dolly, Robison, Nathan, O’Halloran, Katrina, Abbou, Samuel, Berlanga, Pablo, Geoerger, Birgit, Øra, Ingrid, Moertel, Christopher L, Razis, Evangelia D, Vernadou, Anastasia, Doz, François, Laetsch, Theodore W, Perreault, Sébastien
Publicado 2022