Structural principles of SNARE complex recognition by the AAA+ protein NSF

por White, K Ian, Zhao, Minglei, Choi, Ucheor B, Pfuetzner, Richard A, Brunger, Axel T
Publicado 2018

Structural conservation among variants of the SARS-CoV-2 spike postfusion bundle

por Yang, Kailu, Wang, Chuchu, White, K. Ian, Pfuetzner, Richard A., Esquivies, Luis, Brunger, Axel T.
Publicado 2022

Complexin inhibits spontaneous release and synchronizes Ca(2+)-triggered synaptic vesicle fusion by distinct mechanisms

por Lai, Ying, Diao, Jiajie, Cipriano, Daniel J, Zhang, Yunxiang, Pfuetzner, Richard A, Padolina, Mark S, Brunger, Axel T
Publicado 2014

NSF-mediated disassembly of on- and off-pathway SNARE complexes and inhibition by complexin

por Choi, Ucheor B, Zhao, Minglei, White, K Ian, Pfuetzner, Richard A, Esquivies, Luis, Zhou, Qiangjun, Brunger, Axel T
Publicado 2018

Complexin-1 Enhances the On-Rate of Vesicle Docking via Simultaneous SNARE and Membrane Interactions

por Diao, Jiajie, Cipriano, Daniel J., Zhao, Minglei, Zhang, Yunxiang, Shah, Sachi, Padolina, Mark S., Pfuetzner, Richard A., Brunger, Axel T.
Publicado 2013

Structures of neurexophilin–neurexin complexes reveal a regulatory mechanism of alternative splicing

por Wilson, Steven C, White, K Ian, Zhou, Qiangjun, Pfuetzner, Richard A, Choi, Ucheor B, Südhof, Thomas C, Brunger, Axel T
Publicado 2019

Structure-based design of a SARS-CoV-2 Omicron-specific inhibitor

por Yang, Kailu, Wang, Chuchu, Kreutzberger, Alex J. B., White, K. Ian, Pfuetzner, Richard A., Esquivies, Luis, Kirchhausen, Tomas, Brunger, Axel T.
Publicado 2023

Analysis of tripartite Synaptotagmin‐1‐SNARE‐complexin‐1 complexes in solution

por Jaczynska, Klaudia, Esquivies, Luis, Pfuetzner, Richard A., Alten, Baris, Brewer, Kyle D., Zhou, Qiangjun, Kavalali, Ege T., Brunger, Axel T., Rizo, Josep
Publicado 2022

Sensory deficit screen identifies nsf mutation that differentially affects SNARE recycling and quality control

por Gao, Yan, Khan, Yousuf A., Mo, Weike, White, K. Ian, Perkins, Matthew, Pfuetzner, Richard A., Trapani, Josef G., Brunger, Axel T., Nicolson, Teresa
Publicado 2023

Prefused lysosomes cluster on autophagosomes regulated by VAMP8

por Chen, Qixin, Hao, Mingang, Wang, Lei, Li, Linsen, Chen, Yang, Shao, Xintian, Tian, Zhiqi, Pfuetzner, Richard A., Zhong, Qing, Brunger, Axel T., Guan, Jun-Lin, Diao, Jiajie
Publicado 2021

Interactions of the Transmembrane Polymeric Rings of the Salmonella enterica Serovar Typhimurium Type III Secretion System

por Sanowar, Sarah, Singh, Pragya, Pfuetzner, Richard A., André, Ingemar, Zheng, Hongjin, Spreter, Thomas, Strynadka, Natalie C. J., Gonen, Tamir, Baker, David, Goodlett, David R., Miller, Samuel I.
Publicado 2010

Screening of Hydrocarbon-Stapled Peptides for Inhibition of Calcium-Triggered Exocytosis

por Lai, Ying, Tuvim, Michael J., Leitz, Jeremy, Peters, John, Pfuetzner, Richard A., Esquivies, Luis, Zhou, Qiangjun, Czako, Barbara, Cross, Jason B., Jones, Philip, Dickey, Burton F., Brunger, Axel T.
Publicado 2022

Phosphorylation of residues inside the SNARE complex suppresses secretory vesicle fusion

por Malmersjö, Seth, Di Palma, Serena, Diao, Jiajie, Lai, Ying, Pfuetzner, Richard A, Wang, Austin L, McMahon, Moira A, Hayer, Arnold, Porteus, Matthew, Bodenmiller, Bernd, Brunger, Axel T, Meyer, Tobias
Publicado 2016

Munc18a Does Not Alter Fusion Rates Mediated by Neuronal SNAREs, Synaptotagmin, and Complexin

por Zhang, Yunxiang, Diao, Jiajie, Colbert, Karen N., Lai, Ying, Pfuetzner, Richard A., Padolina, Mark S., Vivona, Sandro, Ressl, Susanne, Cipriano, Daniel J., Choi, Ucheor B., Shah, Niket, Weis, William I., Brunger, Axel T.
Publicado 2015

A Refined Model of the Prototypical Salmonella SPI-1 T3SS Basal Body Reveals the Molecular Basis for Its Assembly

por Bergeron, Julien R. C., Worrall, Liam J., Sgourakis, Nikolaos G., DiMaio, Frank, Pfuetzner, Richard A., Felise, Heather B., Vuckovic, Marija, Yu, Angel C., Miller, Samuel I., Baker, David, Strynadka, Natalie C. J.
Publicado 2013

Inhibition of calcium-triggered secretion by hydrocarbon-stapled peptides

por Lai, Ying, Fois, Giorgio, Flores, Jose R., Tuvim, Michael J., Zhou, Qiangjun, Yang, Kailu, Leitz, Jeremy, Peters, John, Zhang, Yunxiang, Pfuetzner, Richard A., Esquivies, Luis, Jones, Philip, Frick, Manfred, Dickey, Burton F., Brunger, Axel T.
Publicado 2022

Drug discovery targeting SARS-CoV-2 membrane fusion

por Yang, Kailu, Wang, Chuchu, Kreutzberger, Alex J.B., Ojha, Ravi, Kuivanen, Suvi, Couoh-Cardel, Sergio, Muratcioglu, Serena, Eisen, Timothy J., White, K. Ian, Pfuetzner, Richard, Kuriyan, John, Vapalahti, Olli, Balistreri, Giuseppe, Kirchhausen, Tomas, Brunger, Axel T.
Publicado 2023

Neutral lysophosphatidylcholine mediates α-synuclein-induced synaptic vesicle clustering

por Lai, Ying, Zhao, Chunyu, Tian, Zhiqi, Wang, Chuchu, Fan, Jiaqi, Hu, Xiao, Tu, Jia, Li, Tihui, Leitz, Jeremy, Pfuetzner, Richard A., Liu, Zhengtao, Zhang, Shengnan, Su, Zhaoming, Burré, Jacqueline, Li, Dan, Südhof , Thomas C., Zhu, Zheng-Jiang, Liu, Cong, Brunger, Axel T., Diao, Jiajie
Publicado 2023

Architecture of the Synaptotagmin-SNARE Machinery for Neuronal Exocytosis

por Zhou, Qiangjun, Lai, Ying, Bacaj, Taulant, Zhao, Minglei, Lyubimov, Artem Y., Uervirojnangkoorn, Monarin, Zeldin, Oliver B., Brewster, Aaron S., Sauter, Nicholas K., Cohen, Aina E., Soltis, S. Michael, Alonso-Mori, Roberto, Chollet, Matthieu, Lemke, Henrik T., Pfuetzner, Richard A., Choi, Ucheor B., Weis, William I., Diao, Jiajie, Südhof, Thomas C., Brunger, Axel T.
Publicado 2015

Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike protein

por Yang, Kailu, Wang, Chuchu, Kreutzberger, Alex J. B., Ojha, Ravi, Kuivanen, Suvi, Couoh-Cardel, Sergio, Muratcioglu, Serena, Eisen, Timothy J., White, K. Ian, Held, Richard G., Subramanian, Subu, Marcus, Kendra, Pfuetzner, Richard A., Esquivies, Luis, Doyle, Catherine A., Kuriyan, John, Vapalahti, Olli, Balistreri, Giuseppe, Kirchhausen, Tom, Brunger, Axel T.
Publicado 2022