The role of KRAS splice variants in cancer biology

por Nuevo-Tapioles, Cristina, Philips, Mark R.
Publicado 2022

Origin and Evolution of RAS Oncoprotein Membrane Targeting

por García-España, Antonio, Philips, Mark R.
Publicado 2023

Regulation of NOTCH signaling by RAB7 and RAB8 requires carboxyl methylation by ICMT

por Court, Helen, Ahearn, Ian M., Amoyel, Marc, Bach, Erika A., Philips, Mark R.
Publicado 2017

NRAS is unique among RAS proteins in requiring ICMT for trafficking to the plasma membrane

por Ahearn, Ian M, Court, Helen R, Siddiqui, Farid, Abankwa, Daniel, Philips, Mark R
Publicado 2021

Differential Localization of Rho Gtpases in Live Cells: Regulation by Hypervariable Regions and Rhogdi Binding

por Michaelson, David, Silletti, Joseph, Murphy, Gretchen, D'Eustachio, Peter, Rush, Mark, Philips, Mark R.
Publicado 2001

Rac1 accumulates in the nucleus during the G2 phase of the cell cycle and promotes cell division

por Michaelson, David, Abidi, Wasif, Guardavaccaro, Daniele, Zhou, Mo, Ahearn, Ian, Pagano, Michele, Philips, Mark R.
Publicado 2008

Rap1 up-regulation and activation on plasma membrane regulates T cell adhesion

por Bivona, Trever G., Wiener, Heidi H., Ahearn, Ian M., Silletti, Joseph, Chiu, Vi K., Philips, Mark R.
Publicado 2004

VPS35 binds farnesylated N-Ras in the cytosol to regulate N-Ras trafficking

por Zhou, Mo, Wiener, Heidi, Su, Wenjuan, Zhou, Yong, Liot, Caroline, Ahearn, Ian, Hancock, John F., Philips, Mark R.
Publicado 2016

Depalmitoylated Ras traffics to and from the Golgi complex via a nonvesicular pathway

por Goodwin, J. Shawn, Drake, Kimberly R., Rogers, Carl, Wright, Latasha, Lippincott-Schwartz, Jennifer, Philips, Mark R., Kenworthy, Anne K.
Publicado 2005

GGTase3 is a Newly Identified Geranylgeranyltransferase Targeting a Ubiquitin Ligase

por Kuchay, Shafi, Wang, Hui, Marzio, Antonio, Jain, Kunj, Homer, Harrison, Fehrenbacher, Nicole, Philips, Mark R., Zheng, Ning, Pagano, Michele
Publicado 2019

Rap1-interacting adapter molecule (RIAM) associates with the plasma membrane via a proximity detector

por Wynne, Joseph P., Wu, Jinhua, Su, Wenjuan, Mor, Adam, Patsoukis, Nikolaos, Boussiotis, Vassiliki A., Hubbard, Stevan R., Philips, Mark R.
Publicado 2012

Single-Walled Carbon Nanotubes Deliver Peptide Antigen into Dendritic Cells and Enhance IgG Responses to Tumor-Associated Antigens

por Villa, Carlos H., Dao, Tao, Ahearn, Ian, Fehrenbacher, Nicole, Casey, Emily, Rey, Diego A., Korontsvit, Tatyana, Zakhaleva, Victoriya, Batt, Carl A., Philips, Mark R., Scheinberg, David A.
Publicado 2011

The G protein–coupled receptor GPR31 promotes membrane association of KRAS

por Fehrenbacher, Nicole, Tojal da Silva, Israel, Ramirez, Craig, Zhou, Yong, Cho, Kwang-Jin, Kuchay, Shafi, Shi, Jie, Thomas, Susan, Pagano, Michele, Hancock, John F., Bar-Sagi, Dafna, Philips, Mark R.
Publicado 2017

A small-molecule ICMT inhibitor delays senescence of Hutchinson-Gilford progeria syndrome cells

por Chen, Xue, Yao, Haidong, Kashif, Muhammad, Revêchon, Gwladys, Eriksson, Maria, Hu, Jianjiang, Wang, Ting, Liu, Yiran, Tüksammel, Elin, Strömblad, Staffan, Ahearn, Ian M, Philips, Mark R, Wiel, Clotilde, Ibrahim, Mohamed X, Bergo, Martin O
Publicado 2021

TRPM8 inhibits endothelial cell migration via a non-channel function by trapping the small GTPase Rap1

por Genova, Tullio, Grolez, Guillaume P., Camillo, Chiara, Bernardini, Michela, Bokhobza, Alexandre, Richard, Elodie, Scianna, Marco, Lemonnier, Loic, Valdembri, Donatella, Munaron, Luca, Philips, Mark R., Mattot, Virginie, Serini, Guido, Prevarskaya, Natalia, Gkika, Dimitra, Pla, Alessandra Fiorio
Publicado 2017

Spontaneous hydrolysis and spurious metabolic properties of α-ketoglutarate esters

por Parker, Seth J., Encarnación-Rosado, Joel, Hollinshead, Kate E. R., Hollinshead, David M., Ash, Leonard J., Rossi, Juan A. K., Lin, Elaine Y., Sohn, Albert S. W., Philips, Mark R., Jones, Drew R., Kimmelman, Alec C.
Publicado 2021

RAB27B controls palmitoylation-dependent NRAS trafficking and signaling in myeloid leukemia

por Ren, Jian-Gang, Xing, Bowen, Lv, Kaosheng, O’Keefe, Rachel A., Wu, Mengfang, Wang, Ruoxing, Bauer, Kaylyn M., Ghazaryan, Arevik, Burslem, George M., Zhang, Jing, O’Connell, Ryan M., Pillai, Vinodh, Hexner, Elizabeth O., Philips, Mark R., Tong, Wei
Publicado 2023

KRAS4A Directly Regulates Hexokinase 1

por Amendola, Caroline R., Mahaffey, James P., Parker, Seth J., Ahearn, Ian M., Chen, Wei-Ching, Zhou, Mo, Court, Helen, Shi, Jie, Mendoza, Sebastian L., Morten, Michael, Rothenberg, Eli, Gottlieb, Eyal, Wadghiri, Youssef Z., Possemato, Richard, Hubbard, Stevan R., Balmain, Allan, Kimmelman, Alec, Philips, Mark R.
Publicado 2019