HDfleX: Software for Flexible High Structural Resolution of Hydrogen/Deuterium-Exchange Mass Spectrometry Data

por Seetaloo, Neeleema, Kish, Monika, Phillips, Jonathan J.
Publicado 2022

Understanding the Relationship Between Biotherapeutic Protein Stability and Solid–Liquid Interfacial Shear in Constant Region Mutants of IgG1 and IgG4

por Tavakoli-Keshe, Roumteen, Phillips, Jonathan J, Turner, Richard, Bracewell, Daniel G
Publicado 2014

Millisecond Hydrogen/Deuterium-Exchange Mass Spectrometry Approach to Correlate Local Structure and Aggregation in α-Synuclein

por Seetaloo, Neeleema, Zacharopoulou, Maria, Stephens, Amberley D., Kaminski Schierle, Gabriele S., Phillips, Jonathan J.
Publicado 2022

Online Fully Automated System for Hydrogen/Deuterium-Exchange Mass Spectrometry with Millisecond Time Resolution

por Kish, Monika, Smith, Victoria, Lethbridge, Natasha, Cole, Lindsay, Bond, Nicholas. J., Phillips, Jonathan J.
Publicado 2023

Different Structural Conformers of Monomeric α-Synuclein Identified after Lyophilizing and Freezing

por Stephens, Amberley D., Nespovitaya, Nadezhda, Zacharopoulou, Maria, Kaminski, Clemens F., Phillips, Jonathan J., Kaminski Schierle, Gabriele S.
Publicado 2018

Allosteric Regulation of Glycogen Phosphorylase by Order/Disorder Transition of the 250′ and 280s Loops

por Kish, Monika, Subramanian, Sivaraman, Smith, Victoria, Lethbridge, Natasha, Cole, Lindsay, Vollmer, Frank, Bond, Nicholas. J., Phillips, Jonathan J.
Publicado 2023

Engineering and exploiting synthetic allostery of NanoLuc luciferase

por Guo, Zhong, Parakra, Rinky D., Xiong, Ying, Johnston, Wayne A., Walden, Patricia, Edwardraja, Selvakumar, Moradi, Shayli Varasteh, Ungerer, Jacobus P. J., Ai, Hui-wang, Phillips, Jonathan J., Alexandrov, Kirill
Publicado 2022

Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity

por Stephens, Amberley D., Zacharopoulou, Maria, Moons, Rani, Fusco, Giuliana, Seetaloo, Neeleema, Chiki, Anass, Woodhams, Philippa J., Mela, Ioanna, Lashuel, Hilal A., Phillips, Jonathan J., De Simone, Alfonso, Sobott, Frank, Schierle, Gabriele S. Kaminski
Publicado 2020

Mechanistic insights into the rational design of masked antibodies

por Orozco, Carolina T., Bersellini, Manuela, Irving, Lorraine M., Howard, Wesley W., Hargreaves, David, Devine, Paul W. A., Siouve, Elise, Browne, Gareth J., Bond, Nicholas J., Phillips, Jonathan J., Ravn, Peter, Jackson, Sophie E.
Publicado 2022

Structural and dynamic insights into the energetics of activation loop rearrangement in FGFR1 kinase

por Klein, Tobias, Vajpai, Navratna, Phillips, Jonathan J., Davies, Gareth, Holdgate, Geoffrey A., Phillips, Chris, Tucker, Julie A., Norman, Richard A., Scott, Andrew D., Higazi, Daniel R., Lowe, David, Thompson, Gary S., Breeze, Alexander L.
Publicado 2015

C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction

por Lautenschläger, Janin, Stephens, Amberley D., Fusco, Giuliana, Ströhl, Florian, Curry, Nathan, Zacharopoulou, Maria, Michel, Claire H., Laine, Romain, Nespovitaya, Nadezhda, Fantham, Marcus, Pinotsi, Dorothea, Zago, Wagner, Fraser, Paul, Tandon, Anurag, St George-Hyslop, Peter, Rees, Eric, Phillips, Jonathan J., De Simone, Alfonso, Kaminski, Clemens F., Schierle, Gabriele S. Kaminski
Publicado 2018

Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo

por Dobson, Claire L., Devine, Paul W. A., Phillips, Jonathan J., Higazi, Daniel R., Lloyd, Christopher, Popovic, Bojana, Arnold, Joanne, Buchanan, Andrew, Lewis, Arthur, Goodman, Joanne, van der Walle, Christopher F., Thornton, Peter, Vinall, Lisa, Lowne, David, Aagaard, Anna, Olsson, Lise-Lotte, Ridderstad Wollberg, Anna, Welsh, Fraser, Karamanos, Theodoros K., Pashley, Clare L., Iadanza, Matthew G., Ranson, Neil A., Ashcroft, Alison E., Kippen, Alistair D., Vaughan, Tristan J., Radford, Sheena E., Lowe, David C.
Publicado 2016