SPOTing Acetyl-Lysine Dependent Interactions

por Picaud, Sarah, Filippakopoulos, Panagis
Publicado 2015

Structural Basis for Recruitment of DAPK1 to the KLHL20 E3 Ligase

por Chen, Zhuoyao, Picaud, Sarah, Filippakopoulos, Panagis, D'Angiolella, Vincenzo, Bullock, Alex N.
Publicado 2019

Stimulation of Hepatic Apolipoprotein A-I Production by Novel Thieno-Triazolodiazepines: Roles of the Classical Benzodiazepine Receptor, PAF Receptor, and Bromodomain Binding

por Kempen, Herman J, Bellus, Daniel, Fedorov, Oleg, Nicklisch, Silke, Filippakopoulos, Panagis, Picaud, Sarah, Knapp, Stefan
Publicado 2013

Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family

por Filippakopoulos, Panagis, Picaud, Sarah, Fedorov, Oleg, Keller, Marco, Wrobel, Matthias, Morgenstern, Olaf, Bracher, Franz, Knapp, Stefan
Publicado 2012

Identification of a PGXPP degron motif in dishevelled and structural basis for its binding to the E3 ligase KLHL12

por Chen, Zhuoyao, Wasney, Gregory A., Picaud, Sarah, Filippakopoulos, Panagis, Vedadi, Masoud, D'Angiolella, Vincenzo, Bullock, Alex N.
Publicado 2020

Structural basis of fumarate hydratase deficiency

por Picaud, Sarah, Kavanagh, Kathryn L., Yue, Wyatt W., Lee, Wen Hwa, Muller-Knapp, Susanne, Gileadi, Opher, Sacchettini, James, Oppermann, Udo
Publicado 2011

Discovery of Novel Small-Molecule Inhibitors of BRD4 Using Structure-Based Virtual Screening

por Vidler, Lewis R., Filippakopoulos, Panagis, Fedorov, Oleg, Picaud, Sarah, Martin, Sarah, Tomsett, Michael, Woodward, Hannah, Brown, Nathan, Knapp, Stefan, Hoelder, Swen
Publicado 2013

9H-Purine Scaffold Reveals Induced-Fit Pocket Plasticity of the BRD9 Bromodomain

por Picaud, Sarah, Strocchia, Maria, Terracciano, Stefania, Lauro, Gianluigi, Mendez, Jacqui, Daniels, Danette L., Riccio, Raffaele, Bifulco, Giuseppe, Bruno, Ines, Filippakopoulos, Panagis
Publicado 2015

Structures of PGAM5 Provide Insight into Active Site Plasticity and Multimeric Assembly

por Chaikuad, Apirat, Filippakopoulos, Panagis, Marcsisin, Sean R., Picaud, Sarah, Schröder, Martin, Sekine, Shiori, Ichijo, Hidenori, Engen, John R., Takeda, Kohsuke, Knapp, Stefan
Publicado 2017

MOB1 Mediated Phospho-recognition in the Core Mammalian Hippo Pathway

por Couzens, Amber L., Xiong, Shawn, Knight, James D. R., Mao, Daniel Y., Guettler, Sebastian, Picaud, Sarah, Kurinov, Igor, Filippakopoulos, Panagis, Sicheri, Frank, Gingras, Anne-Claude
Publicado 2017

3,5-Dimethylisoxazoles Act As Acetyl-lysine-mimetic Bromodomain Ligands

por Hewings, David S., Wang, Minghua, Philpott, Martin, Fedorov, Oleg, Uttarkar, Sagar, Filippakopoulos, Panagis, Picaud, Sarah, Vuppusetty, Chaitanya, Marsden, Brian, Knapp, Stefan, Conway, Stuart J., Heightman, Tom D.
Publicado 2011

A TFEB nuclear export signal integrates amino acid supply and glucose availability

por Li, Linxin, Friedrichsen, Hans J., Andrews, Sarah, Picaud, Sarah, Volpon, Laurent, Ngeow, Kaochin, Berridge, Georgina, Fischer, Roman, Borden, Katherine L. B., Filippakopoulos, Panagis, Goding, Colin R.
Publicado 2018

Discovery of Benzo[d]imidazole‐6‐sulfonamides as Bromodomain and Extra‐Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain

por Cipriano, Alessandra, Milite, Ciro, Feoli, Alessandra, Viviano, Monica, Pepe, Giacomo, Campiglia, Pietro, Sarno, Giuliana, Picaud, Sarah, Imaide, Satomi, Makukhin, Nikolai, Filippakopoulos, Panagis, Ciulli, Alessio, Castellano, Sabrina, Sbardella, Gianluca
Publicado 2022

DNA damage-induced interaction between a lineage addiction oncogenic transcription factor and the MRN complex shapes a tissue-specific DNA Damage Response and cancer predisposition

por Binet, Romuald, Lambert, Jean-Philippe, Tomkova, Marketa, Tischfield, Samuel, Baggiolini, Arianna, Picaud, Sarah, Sarkar, Sovan, Louphrasitthiphol, Pakavarin, Dias, Diogo, Carreira, Suzanne, Humphrey, Timothy, Fillipakopoulos, Panagis, White, Richard, Goding, Colin R
Publicado 2023

Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family

por Filippakopoulos, Panagis, Picaud, Sarah, Mangos, Maria, Keates, Tracy, Lambert, Jean-Philippe, Barsyte-Lovejoy, Dalia, Felletar, Ildiko, Volkmer, Rudolf, Müller, Susanne, Pawson, Tony, Gingras, Anne-Claude, Arrowsmith, Cheryl H., Knapp, Stefan
Publicado 2012

Small-Molecule Inhibition of BRDT for Male Contraception

por Matzuk, Martin M., McKeown, Michael R., Filippakopoulos, Panagis, Li, Qinglei, Ma, Lang, Agno, Julio E., Lemieux, Madeleine E., Picaud, Sarah, Yu, Richard N., Qi, Jun, Knapp, Stefan, Bradner, James E.
Publicado 2012

[1,2,4]Triazolo[4,3-a]phthalazines: Inhibitors of Diverse Bromodomains

por Fedorov, Oleg, Lingard, Hannah, Wells, Chris, Monteiro, Octovia P., Picaud, Sarah, Keates, Tracy, Yapp, Clarence, Philpott, Martin, Martin, Sarah J., Felletar, Ildiko, Marsden, Brian D., Filippakopoulos, Panagis, Müller, Susanne, Knapp, Stefan, Brennan, Paul E.
Publicado 2013

The structure of nontypeable Haemophilus influenzae SapA in a closed conformation reveals a constricted ligand-binding cavity and a novel RNA binding motif

por Lukacik, Petra, Owen, C. David, Harris, Gemma, Bolla, Jani Reddy, Picaud, Sarah, Alibay, Irfan, Nettleship, Joanne E., Bird, Louise E., Owens, Raymond J., Biggin, Philip C., Filippakopoulos, Panagis, Robinson, Carol V., Walsh, Martin A.
Publicado 2021

Acetylation reprograms MITF target selectivity and residence time

por Louphrasitthiphol, Pakavarin, Loffreda, Alessia, Pogenberg, Vivian, Picaud, Sarah, Schepsky, Alexander, Friedrichsen, Hans, Zeng, Zhiqiang, Lashgari, Anahita, Thomas, Benjamin, Patton, E. Elizabeth, Wilmanns, Matthias, Filippakopoulos, Panagis, Lambert, Jean-Philippe, Steingrímsson, Eiríkur, Mazza, Davide, Goding, Colin R.
Publicado 2023

Dual kinase-bromodomain inhibitors for rationally designed polypharmacology

por Ciceri, Pietro, Müller, Susanne, O’Mahony, Alison, Fedorov, Oleg, Filippakopoulos, Panagis, Hunt, Jeremy P., Lasater, Elisabeth A., Pallares, Gabriel, Picaud, Sarah, Wells, Christopher, Martin, Sarah, Wodicka, Lisa M., Shah, Neil P., Treiber, Daniel K., Knapp, Stefan
Publicado 2014