NEURONAL-SPECIFIC PROTEASOME AUGMENTATION VIA EXTENDS LIFESPAN AND REDUCES AGE-RELATED NEURODEGENERATION

por Pickering, Andrew M
Publicado 2019

The proteasome: A key modulator of nervous system function, brain aging, and neurodegenerative disease

por Davidson, Kanisa, Pickering, Andrew M.
Publicado 2023

Protein translation paradox: Implications in translational regulation of aging

por Kim, Harper S., Pickering, Andrew M.
Publicado 2023

Mitochondrial TrxR2 regulates metabolism and protects from metabolic disease through enhanced TCA and ETC function

por Chocron, E. Sandra, Mdaki, Kennedy, Jiang, Nisi, Cropper, Jodie, Pickering, Andrew M.
Publicado 2022

Mitochondrial thioredoxin reductase 2 is elevated in long‐lived primate as well as rodent species and extends fly mean lifespan

por Pickering, Andrew M., Lehr, Marcus, Gendron, Christi M., Pletcher, Scott D., Miller, Richard A.
Publicado 2017

New Peptide-Based Pharmacophore Activates 20S Proteasome

por Osmulski, Paweł A., Karpowicz, Przemysław, Jankowska, Elżbieta, Bohmann, Jonathan, Pickering, Andrew M., Gaczyńska, Maria
Publicado 2020

Neuronal‐specific proteasome augmentation via Prosβ5 overexpression extends lifespan and reduces age‐related cognitive decline

por Munkácsy, Erin, Chocron, E. Sandra, Quintanilla, Laura, Gendron, Christi M., Pletcher, Scott D., Pickering, Andrew M.
Publicado 2019

Proline- and Arginine-Rich Peptides as Flexible Allosteric Modulators of Human Proteasome Activity

por Giżyńska, Małgorzata, Witkowska, Julia, Karpowicz, Przemysław, Rostankowski, Rafał, Chocron, Estrella S., Pickering, Andrew M., Osmulski, Pawel, Gaczynska, Maria, Jankowska, Elżbieta
Publicado 2018

Early-adulthood spike in protein translation drives aging via juvenile hormone/germline signaling

por Kim, Harper S., Parker, Danitra J., Hardiman, Madison M., Munkácsy, Erin, Jiang, Nisi, Rogers, Aric N., Bai, Yidong, Brent, Colin, Mobley, James A., Austad, Steven N., Pickering, Andrew M.
Publicado 2023

Gut- and oral-dysbiosis differentially impact spinal- and bulbar-onset ALS, predicting ALS severity and potentially determining the location of disease onset

por Kim, Harper S., Son, John, Lee, Donghwan, Tsai, Joy, Wang, Danny, Chocron, E. Sandra, Jeong, Seongwoo, Kittrell, Pamela, Murchison, Charles F., Kennedy, Richard E., Tobon, Alejandro, Jackson, Carlayne E., Pickering, Andrew M.
Publicado 2022

Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer’s-like pathology in mouse and fly APP overexpression models

por Chocron, E. Sandra, Munkácsy, Erin, Kim, Harper S., Karpowicz, Przemyslaw, Jiang, Nisi, Van Skike, Candice E., DeRosa, Nicholas, Banh, Andy Q., Palavicini, Juan P., Wityk, Paweł, Kalinowski, Leszek, Galvan, Veronica, Osmulski, Pawel A., Jankowska, Elzbieta, Gaczynska, Maria, Pickering, Andrew M.
Publicado 2022

Tumor-Reprogrammed Stromal BCAT1 Fuels Branched Chain Ketoacid Dependency in Stromal-Rich PDAC Tumors

por Zhu, Ziwen, Achreja, Abhinav, Meurs, Noah, Animasahun, Olamide, Owen, Sarah, Mittal, Anjali, Parikh, Pooja, Lo, Ting-Wen, Franco-Barraza, Janusz, Shi, Jiaqi, Gunchick, Valerie, Sherman, Mara H., Cukierman, Edna, Pickering, Andrew M., Maitra, Anirban, Sahai, Vaibhav, Morgan, Meredith A., Nagrath, Sunitha, Lawrence, Theodore S., Nagrath, Deepak
Publicado 2020