Pathogenesis/genetics of frontotemporal dementia and how it relates to ALS

por Bennion Callister, Janis, Pickering-Brown, Stuart M.
Publicado 2014

C9orf72 dipeptides disrupt the nucleocytoplasmic transport machinery and cause TDP-43 mislocalisation to the cytoplasm

por Ryan, Sarah, Rollinson, Sara, Hobbs, Eleanor, Pickering-Brown, Stuart
Publicado 2022

Modelling C9orf72 dipeptide repeat proteins of a physiologically relevant size

por Bennion Callister, Janis, Ryan, Sarah, Sim, Joan, Rollinson, Sara, Pickering-Brown, Stuart M.
Publicado 2016

The cellular expression and proteolytic processing of the amyloid precursor protein is independent of TDP-43

por Hicks, David A., Jones, Alys C., Pickering-Brown, Stuart M., Hooper, Nigel M.
Publicado 2020

Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17)

por Wszolek, Zbigniew K, Tsuboi, Yoshio, Ghetti, Bernardino, Pickering-Brown, Stuart, Baba, Yasuhiko, Cheshire, William P
Publicado 2006

Immunohistochemical detection of C9orf72 protein in frontotemporal lobar degeneration and motor neurone disease: patterns of immunostaining and an evaluation of commercial antibodi...

por Davidson, Yvonne S., Robinson, Andrew C., Rollinson, Sara, Pickering-Brown, Stuart, Xiao, Shangxi, Robertson, Janice, Mann, David M. A.
Publicado 2017

Co-expression of C9orf72 related dipeptide-repeats over 1000 repeat units reveals age- and combination-specific phenotypic profiles in Drosophila

por West, Ryan J. H., Sharpe, Joanne L., Voelzmann, André, Munro, Anna L., Hahn, Ines, Baines, Richard A., Pickering-Brown, Stuart
Publicado 2020

Extracellular Vesicles Isolated from Human Induced Pluripotent Stem Cell-Derived Neurons Contain a Transcriptional Network

por Hicks, David A., Jones, Alys C., Corbett, Nicola J., Fisher, Kate, Pickering-Brown, Stuart M., Ashe, Mark P., Hooper, Nigel M.
Publicado 2020

TDP-43 protein in plasma may index TDP-43 brain pathology in Alzheimer’s disease and frontotemporal lobar degeneration

por Foulds, Penelope, McAuley, Erica, Gibbons, Linda, Davidson, Yvonne, Pickering-Brown, Stuart M., Neary, David, Snowden, Julie S., Allsop, David, Mann, David M. A.
Publicado 2008

Genomewide association study in cervical dystonia demonstrates possible association with sodium leak channel

por Mok, Kin Y, Schneider, Susanne A, Trabzuni, Daniah, Stamelou, Maria, Edwards, Mark, Kasperaviciute, Dalia, Pickering-Brown, Stuart, Silverdale, Monty, Hardy, John, Bhatia, Kailash P
Publicado 2014

Heterogeneity of ubiquitin pathology in frontotemporal lobar degeneration: classification and relation to clinical phenotype

por Mackenzie, Ian R. A., Baborie, Atik, Pickering-Brown, Stuart, Plessis, Daniel Du, Jaros, Evelyn, Perry, Robert H., Neary, David, Snowden, Julie S., Mann, David M. A.
Publicado 2006

Plasma levels of progranulin and interleukin-6 in frontotemporal lobar degeneration

por Gibbons, Linda, Rollinson, Sara, Thompson, Jennifer C., Robinson, Andrew, Davidson, Yvonne S., Richardson, Anna, Neary, David, Pickering-Brown, Stuart M., Snowden, Julie S., Mann, David M.A.
Publicado 2015

Antisense RNA foci in the motor neurons of C9ORF72-ALS patients are associated with TDP-43 proteinopathy

por Cooper-Knock, Johnathan, Higginbottom, Adrian, Stopford, Matthew J., Highley, J. Robin, Ince, Paul G., Wharton, Stephen B., Pickering-Brown, Stuart, Kirby, Janine, Hautbergue, Guillaume M., Shaw, Pamela J.
Publicado 2015

Dipeptide repeat proteins are present in the p62 positive inclusions in patients with frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9OR...

por Mann, David MA, Rollinson, Sara, Robinson, Andrew, Bennion Callister, Janis, Thompson, Jennifer C, Snowden, Julie S, Gendron, Tania, Petrucelli, Leonard, Masuda-Suzukake, Masami, Hasegawa, Masato, Davidson, Yvonne, Pickering-Brown, Stuart
Publicado 2013

Heterogeneous ribonuclear protein E2 (hnRNP E2) is associated with TDP-43-immunoreactive neurites in Semantic Dementia but not with other TDP-43 pathological subtypes of Frontotemp...

por Davidson, Yvonne S., Robinson, Andrew C., Flood, Louis, Rollinson, Sara, Benson, Bridget C., Asi, Yasmine T., Richardson, Anna, Jones, Matthew, Snowden, Julie S., Pickering-Brown, Stuart, Lashley, Tammaryn, Mann, David M. A.
Publicado 2017

Heterogeneous ribonuclear protein A3 (hnRNP A3) is present in dipeptide repeat protein containing inclusions in Frontotemporal Lobar Degeneration and Motor Neurone disease associat...

por Davidson, Yvonne S., Flood, Louis, Robinson, Andrew C., Nihei, Yoshihiro, Mori, Kohji, Rollinson, Sara, Richardson, Anna, Benson, Bridget C., Jones, Matthew, Snowden, Julie S., Pickering-Brown, Stuart, Haass, Christian, Lashley, Tammaryn, Mann, David M. A.
Publicado 2017

Accumulation of dipeptide repeat proteins predates that of TDP‐43 in frontotemporal lobar degeneration associated with hexanucleotide repeat expansions in C9ORF72 gene

por Baborie, Atik, Griffiths, Timothy D., Jaros, Evelyn, Perry, Robert, McKeith, Ian G., Burn, David J., Masuda‐Suzukake, Masami, Hasegawa, Masato, Rollinson, Sara, Pickering‐Brown, Stuart, Robinson, Andrew C., Davidson, Yvonne S., Mann, David M. A.
Publicado 2015

Brain distribution of dipeptide repeat proteins in frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9ORF72

por Davidson, Yvonne S, Barker, Holly, Robinson, Andrew C, Thompson, Jennifer C, Harris, Jenny, Troakes, Claire, Smith, Bradley, Al-Saraj, Safa, Shaw, Chris, Rollinson, Sara, Masuda-Suzukake, Masami, Hasegawa, Masato, Pickering-Brown, Stuart, Snowden, Julie S, Mann, David M
Publicado 2014

Cognition and behaviour in frontotemporal dementia with and without amyotrophic lateral sclerosis

por Saxon, Jennifer A, Thompson, Jennifer C, Harris, Jennifer M, Richardson, Anna M, Langheinrich, Tobias, Rollinson, Sara, Pickering-Brown, Stuart, Chaouch, Amina, Ealing, John, Hamdalla, Hisham, Young, Carolyn A, Blackburn, Dan, Majeed, Tahir, Gall, Claire, Jones, Matthew, Snowden, Julie S
Publicado 2020

A small deletion in C9orf72 hides a proportion of expansion carriers in FTLD

por Rollinson, Sara, Bennion Callister, Janis, Young, Kate, Ryan, Sarah J., Druyeh, Ronald, Rohrer, Jonathan D., Snowden, Julie, Richardson, Anna, Jones, Matt, Harris, Jenny, Davidson, Yvonne, Robinson, Andrew, Ealing, John, Johnson, Janel O., Traynor, Bryan, Mead, Simon, Mann, David, Pickering-Brown, Stuart M.
Publicado 2015