Clinically relevant fluoroquinolone resistance due to constitutive overexpression of the PatAB ABC transporter in Streptococcus pneumoniae is conferred by disruption of a transcrip...

por Baylay, Alison J., Piddock, Laura J. V.
Publicado 2015

How to Measure Export via Bacterial Multidrug Resistance Efflux Pumps

por Blair, Jessica M. A., Piddock, Laura J. V.
Publicado 2016

A Novel Gene Amplification Causes Upregulation of the PatAB ABC Transporter and Fluoroquinolone Resistance in Streptococcus pneumoniae

por Baylay, Alison J., Ivens, Alasdair, Piddock, Laura J. V.
Publicado 2015

RamA, which controls expression of the MDR efflux pump AcrAB-TolC, is regulated by the Lon protease

por Ricci, Vito, Blair, Jessica M. A., Piddock, Laura J. V.
Publicado 2014

The O-Antigen Epitope Governs Susceptibility to Colistin in Salmonella enterica

por Ricci, Vito, Zhang, Dexian, Teale, Christopher, Piddock, Laura J. V.
Publicado 2020

Strategies to combat antimicrobial resistance: anti-plasmid and plasmid curing

por Buckner, Michelle M C, Ciusa, Maria Laura, Piddock, Laura J V
Publicado 2018

CsrA maximizes expression of the AcrAB multidrug resistance transporter

por Ricci, Vito, Attah, Victoria, Overton, Tim, Grainger, David C., Piddock, Laura J.V.
Publicado 2017

Absence, loss-of-function, or inhibition of Escherichia coli AcrB does not increase expression of other efflux pump genes supporting the discovery of AcrB inhibitors as antibiotic...

por Ciusa, Maria Laura, Marshall, Robert L, Ricci, Vito, Stone, Jack W, Piddock, Laura J V
Publicado 2021

Choice of Bacterial Growth Medium Alters the Transcriptome and Phenotype of Salmonella enterica Serovar Typhimurium

por Blair, Jessica M. A., Richmond, Grace E., Bailey, Andrew M., Ivens, Al, Piddock, Laura J. V.
Publicado 2013

Acquisition and Loss of CTX-M-Producing and Non-Producing Escherichia coli in the Fecal Microbiome of Travelers to South Asia

por Bevan, Edward R., McNally, Alan, Thomas, Christopher M., Piddock, Laura J. V., Hawkey, Peter M.
Publicado 2018

A Nonprofit Drug Development Model Is Part of the Antimicrobial Resistance (AMR) Solution

por Piddock, Laura J V, Paccaud, Jean-Pierre, O’Brien, Seamus, Childs, Michelle, Malpani, Rohit, Balasegaram, Manica
Publicado 2021

Clinically Relevant Mutant DNA Gyrase Alters Supercoiling, Changes the Transcriptome, and Confers Multidrug Resistance

por Webber, Mark A., Ricci, Vito, Whitehead, Rebekah, Patel, Meha, Fookes, Maria, Ivens, Alasdair, Piddock, Laura J. V.
Publicado 2013

Time dependent asymptotic analysis of the gene regulatory network of the AcrAB-TolC efflux pump system in gram-negative bacteria

por Youlden, George H., Ricci, Vito, Wang-Kan, Xuan, Piddock, Laura J. V., Jabbari, Sara, King, John R.
Publicado 2021

Parallel evolutionary pathways to antibiotic resistance selected by biocide exposure

por Webber, Mark A., Whitehead, Rebekah N., Mount, Manuella, Loman, Nick J., Pallen, Mark J., Piddock, Laura J. V.
Publicado 2015

Mapping direct and indirect MarA/SoxS/Rob/RamA regulons in Salmonella Typhimurium reveals repression of csgD and biofilm formation

por Middlemiss, Alistair D., Haycocks, James R. J., Stringer, Anne M., Piddock, Laura J. V., Wade, Joseph T., Grainger, David C.
Publicado 2023

Expression of homologous RND efflux pump genes is dependent upon AcrB expression: implications for efflux and virulence inhibitor design

por Blair, Jessica M. A., Smith, Helen E., Ricci, Vito, Lawler, Amelia J., Thompson, Louisa J., Piddock, Laura J. V.
Publicado 2015

The role of combination therapy in the treatment of severe infections caused by carbapenem resistant gram-negatives: a systematic review of clinical studies

por Savoldi, Alessia, Carrara, Elena, Piddock, Laura J. V., Franceschi, Francois, Ellis, Sally, Chiamenti, Margherita, Bragantini, Damiano, Righi, Elda, Tacconelli, Evelina
Publicado 2021

Metabolomics Reveal Potential Natural Substrates of AcrB in Escherichia coli and Salmonella enterica Serovar Typhimurium

por Wang-Kan, Xuan, Rodríguez-Blanco, Giovanny, Southam, Andrew D., Winder, Catherine L., Dunn, Warwick B., Ivens, Alasdair, Piddock, Laura J. V.
Publicado 2021

Reduced Fluoroquinolone Susceptibility in Salmonella enterica Isolates from Travelers, Finland

por Lindgren, Marianne M., Kotilainen, Pirkko, Huovinen, Pentti, Hurme, Saija, Lukinmaa, Susanna, Webber, Mark A., Piddock, Laura J.V., Siitonen, Anja, Hakanen, Antti J.
Publicado 2009

Beyond Antimicrobial Resistance: Evidence for a Distinct Role of the AcrD Efflux Pump in Salmonella Biology

por Buckner, Michelle M. C., Blair, Jessica M. A., La Ragione, Roberto M., Newcombe, Jane, Dwyer, Daniel J., Ivens, Alasdair, Piddock, Laura J. V.
Publicado 2016