Amyloid-β oligomers unveil a novel primate model of sporadic Alzheimer's disease

por Jebelli, Joseph D., Piers, Thomas M.
Publicado 2015

Translational Concepts of mGluR5 in Synaptic Diseases of the Brain

por Piers, Thomas M., Kim, Dong Hyun, Kim, Byeong C., Regan, Philip, Whitcomb, Daniel J., Cho, Kwangwook
Publicado 2012

The influence of the R47H triggering receptor expressed on myeloid cells 2 variant on microglial exosome profiles

por Mallach, Anna, Gobom, Johan, Zetterberg, Henrik, Hardy, John, Piers, Thomas M, Wray, Selina, Pocock, Jennifer M
Publicado 2021

A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC‐derived microglia

por Piers, Thomas M., Cosker, Katharina, Mallach, Anna, Johnson, Gabriel Thomas, Guerreiro, Rita, Hardy, John, Pocock, Jennifer M.
Publicado 2019

Differential Stimulation of Pluripotent Stem Cell-Derived Human Microglia Leads to Exosomal Proteomic Changes Affecting Neurons

por Mallach, Anna, Gobom, Johan, Arber, Charles, Piers, Thomas M., Hardy, John, Wray, Selina, Zetterberg, Henrik, Pocock, Jennifer
Publicado 2021

Soluble Fibrinogen Triggers Non-cell Autonomous ER Stress-Mediated Microglial-Induced Neurotoxicity

por Piers, Thomas M., East, Emma, Villegas-Llerena, Claudio, Sevastou, Ioanna G., Matarin, Mar, Hardy, John, Pocock, Jennifer M.
Publicado 2018

Postsynaptic p47phox regulates long-term depression in the hippocampus

por Yi, Jee Hyun, Kim, Dong Hyun, Piers, Thomas M., Kim, Seung Chan, Whitcomb, Daniel J., Regan, Philip, Cho, Kwangwook
Publicado 2018

Microglial signalling pathway deficits associated with the patient derived R47H TREM2 variants linked to AD indicate inability to activate inflammasome

por Cosker, Katharina, Mallach, Anna, Limaye, Janhavi, Piers, Thomas M., Staddon, James, Neame, Stephen J., Hardy, John, Pocock, Jennifer M.
Publicado 2021

Abrogation of LRRK2 dependent Rab10 phosphorylation with TLR4 activation and alterations in evoked cytokine release in immune cells

por Nazish, Iqra, Arber, Charles, Piers, Thomas M., Warner, Thomas T., Hardy, John A., Lewis, Patrick A., Pocock, Jennifer M., Bandopadhyay, Rina
Publicado 2021

The Trem2 R47H Alzheimer’s risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans

por Xiang, Xianyuan, Piers, Thomas M., Wefers, Benedikt, Zhu, Kaichuan, Mallach, Anna, Brunner, Bettina, Kleinberger, Gernot, Song, Wilbur, Colonna, Marco, Herms, Jochen, Wurst, Wolfgang, Pocock, Jennifer M., Haass, Christian
Publicado 2018

Activation of a synapse weakening pathway by human Val66 but not Met66 pro-brain-derived neurotrophic factor (proBDNF)

por Kailainathan, Sumangali, Piers, Thomas M., Yi, Jee Hyun, Choi, Seongmin, Fahey, Mark S., Borger, Eva, Gunn-Moore, Frank J., O’Neill, Laurie, Lever, Michael, Whitcomb, Daniel J., Cho, Kwangwook, Allen, Shelley J.
Publicado 2016

Microtubule-associated protein tau is essential for long-term depression in the hippocampus

por Kimura, Tetsuya, Whitcomb, Daniel J., Jo, Jihoon, Regan, Philip, Piers, Thomas, Heo, Seonghoo, Brown, Christopher, Hashikawa, Tsutomu, Murayama, Miyuki, Seok, Heon, Sotiropoulos, Ioannis, Kim, Eunjoon, Collingridge, Graham L., Takashima, Akihiko, Cho, Kwangwook
Publicado 2014

Intracellular oligomeric amyloid-beta rapidly regulates GluA1 subunit of AMPA receptor in the hippocampus

por Whitcomb, Daniel J., Hogg, Ellen L., Regan, Philip, Piers, Thomas, Narayan, Priyanka, Whitehead, Garry, Winters, Bryony L., Kim, Dong-Hyun, Kim, Eunjoon, St George-Hyslop, Peter, Klenerman, David, Collingridge, Graham L., Jo, Jihoon, Cho, Kwangwook
Publicado 2015

Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in Phagocytosis

por Garcia-Reitboeck, Pablo, Phillips, Alexandra, Piers, Thomas M., Villegas-Llerena, Claudio, Butler, Matt, Mallach, Anna, Rodrigues, Celia, Arber, Charles E., Heslegrave, Amanda, Zetterberg, Henrik, Neumann, Harald, Neame, Stephen, Houlden, Henry, Hardy, John, Pocock, Jennifer M.
Publicado 2018

Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions

por Liu, Wenfei, Taso, Orjona, Wang, Rui, Bayram, Sevinc, Graham, Andrew C, Garcia-Reitboeck, Pablo, Mallach, Anna, Andrews, William D, Piers, Thomas M, Botia, Juan A, Pocock, Jennifer M, Cummings, Damian M, Hardy, John, Edwards, Frances A, Salih, Dervis A
Publicado 2020

Acute stress causes rapid synaptic insertion of Ca(2+)-permeable AMPA receptors to facilitate long-term potentiation in the hippocampus

por Whitehead, Garry, Jo, Jihoon, Hogg, Ellen L., Piers, Thomas, Kim, Dong-Hyun, Seaton, Gillian, Seok, Heon, Bru-Mercier, Gilles, Son, Gi Hoon, Regan, Philip, Hildebrandt, Lars, Waite, Eleanor, Kim, Byeong-Chae, Kerrigan, Talitha L., Kim, Kyungjin, Whitcomb, Daniel J., Collingridge, Graham L., Lightman, Stafford L., Cho, Kwangwook
Publicado 2013

A genetic link between risk for Alzheimer's disease and severe COVID-19 outcomes via the OAS1 gene

por Magusali, Naciye, Graham, Andrew C, Piers, Thomas M, Panichnantakul, Pantila, Yaman, Umran, Shoai, Maryam, Reynolds, Regina H, Botia, Juan A, Brookes, Keeley J, Guetta-Baranes, Tamar, Bellou, Eftychia, Bayram, Sevinc, Sokolova, Dimitra, Ryten, Mina, Sala Frigerio, Carlo, Escott-Price, Valentina, Morgan, Kevin, Pocock, Jennifer M, Hardy, John, Salih, Dervis A
Publicado 2021