Asbestos Induces Oxidative Stress and Activation of Nrf2 Signaling in Murine Macrophages: Chemopreventive Role of the Synthetic Lignan Secoisolariciresinol Diglucoside (LGM2605)

por Pietrofesa, Ralph A., Velalopoulou, Anastasia, Albelda, Steven M., Christofidou-Solomidou, Melpo
Publicado 2016

The Flaxseed-Derived Lignan Phenolic Secoisolariciresinol Diglucoside (SDG) Protects Non-Malignant Lung Cells from Radiation Damage

por Velalopoulou, Anastasia, Tyagi, Sonia, Pietrofesa, Ralph A., Arguiri, Evguenia, Christofidou-Solomidou, Melpo
Publicado 2015

Gamma-irradiation produces active chlorine species (ACS) in physiological solutions: Secoisolariciresinol diglucoside (SDG) scavenges ACS - A novel mechanism of DNA radioprotection

por Mishra, Om P., Popov, Anatoliy V., Pietrofesa, Ralph A., Christofidou-Solomidou, Melpo
Publicado 2016

Late Inflammation Induced by Asbestiform Fibers in Mice Is Ameliorated by a Small Molecule Synthetic Lignan

por Badger, Reagan, Park, Kyewon, Pietrofesa, Ralph A., Christofidou-Solomidou, Melpo, Serve, Kinta M.
Publicado 2021

Flaxseed modulates inflammatory and oxidative stress biomarkers in cystic fibrosis: a pilot study

por Turowski, Jason B, Pietrofesa, Ralph A, Lawson, John A, Christofidou-Solomidou, Melpo, Hadjiliadis, Denis
Publicado 2015

Synthetic Secoisolariciresinol Diglucoside Attenuates Established Pain, Oxidative Stress and Neuroinflammation in a Rodent Model of Painful Radiculopathy

por Kartha, Sonia, Weisshaar, Christine L., Pietrofesa, Ralph A., Christofidou-Solomidou, Melpo, Winkelstein, Beth A.
Publicado 2020

Synthetic Lignan Secoisolariciresinol Diglucoside (LGM2605) Reduces Asbestos-Induced Cytotoxicity in an Nrf2-Dependent and -Independent Manner

por Pietrofesa, Ralph A., Chatterjee, Shampa, Park, Kyewon, Arguiri, Evguenia, Albelda, Steven M., Christofidou-Solomidou, Melpo
Publicado 2018

Synthetic Secoisolariciresinol Diglucoside (LGM2605) Prevents Asbestos-Induced Inflammation and Genotoxic Cell Damage in Human Mesothelial Cells

por Pietrofesa, Ralph A., Chatterjee, Shampa, Kadariya, Yuwaraj, Testa, Joseph R., Albelda, Steven M., Christofidou-Solomidou, Melpo
Publicado 2022

The Synthetic Lignan Secoisolariciresinol Diglucoside Prevents Asbestos-Induced NLRP3 Inflammasome Activation in Murine Macrophages

por Pietrofesa, Ralph A., Woodruff, Patrick, Hwang, Wei-Ting, Patel, Priyal, Chatterjee, Shampa, Albelda, Steven M., Christofidou-Solomidou, Melpo
Publicado 2017

Gene expression profiling of flaxseed in mouse lung tissues-modulation of toxicologically relevant genes

por Dukes, Floyd, Kanterakis, Stathis, Lee, James, Pietrofesa, Ralph, Andersen, Emily S, Arguiri, Evguenia, Tyagi, Sonia, Showe, Louise, Amrani, Yassine, Christofidou-Solomidou, Melpo
Publicado 2012

Flaxseed lignans enriched in secoisolariciresinol diglucoside prevent acute asbestos-induced peritoneal inflammation in mice

por Pietrofesa, Ralph A., Velalopoulou, Anastasia, Arguiri, Evguenia, Menges, Craig W., Testa, Joseph R., Hwang, Wei-Ting, Albelda, Steven M., Christofidou-Solomidou, Melpo
Publicado 2016

LGM2605 Reduces Space Radiation-Induced NLRP3 Inflammasome Activation and Damage in In Vitro Lung Vascular Networks

por Chatterjee, Shampa, Pietrofesa, Ralph A., Park, Kyewon, Tao, Jian-Qin, Carabe-Fernandez, Alejandro, Berman, Abigail T., Koumenis, Constantinos, Sielecki, Thais, Christofidou-Solomidou, Melpo
Publicado 2019

Synthetic Secoisolariciresinol Diglucoside (LGM2605) Protects Human Lung in an Ex Vivo Model of Proton Radiation Damage

por Velalopoulou, Anastasia, Chatterjee, Shampa, Pietrofesa, Ralph A., Koziol-White, Cynthia, Panettieri, Reynold A., Lin, Liyong, Tuttle, Stephen, Berman, Abigail, Koumenis, Constantinos, Christofidou-Solomidou, Melpo
Publicado 2017

Assessment of a Small Molecule Synthetic Lignan in Enhancing Oxidative Balance and Decreasing Lipid Accumulation in Human Retinal Pigment Epithelia

por Dhingra, Anuradha, Sharp, Rachel C., Kim, Taewan, Popov, Anatoliy V., Ying, Gui-Shuang, Pietrofesa, Ralph A., Park, Kyewon, Christofidou-Solomidou, Melpo, Boesze-Battaglia, Kathleen
Publicado 2021

Dietary flaxseed administered post thoracic radiation treatment improves survival and mitigates radiation-induced pneumonopathy in mice

por Christofidou-Solomidou, Melpo, Tyagi, Sonia, Tan, Kay-See, Hagan, Sarah, Pietrofesa, Ralph, Dukes, Floyd, Arguiri, Evguenia, Heitjan, Daniel F, Solomides, Charalambos C, Cengel, Keith A
Publicado 2011

Radiation mitigating properties of the lignan component in flaxseed

por Pietrofesa, Ralph, Turowski, Jason, Tyagi, Sonia, Dukes, Floyd, Arguiri, Evguenia, Busch, Theresa M, Gallagher-Colombo, Shannon M, Solomides, Charalambos C, Cengel, Keith A, Christofidou-Solomidou, Melpo
Publicado 2013

Novel Double-Hit Model of Radiation and Hyperoxia-Induced Oxidative Cell Damage Relevant to Space Travel

por Pietrofesa, Ralph A., Velalopoulou, Anastasia, Lehman, Stacey L., Arguiri, Evguenia, Solomides, Pantelis, Koch, Cameron J., Mishra, Om P., Koumenis, Constantinos, Goodwin, Thomas J., Christofidou-Solomidou, Melpo
Publicado 2016

Copper Oxide Nanoparticle-Induced Acute Inflammatory Response and Injury in Murine Lung Is Ameliorated by Synthetic Secoisolariciresinol Diglucoside (LGM2605)

por Pietrofesa, Ralph A., Park, Kyewon, Mishra, Om P., Johnson-McDaniel, Darrah, Myerson, Jacob W., Shuvaev, Vladimir V., Arguiri, Evguenia, Chatterjee, Shampa, Moorthy, Ganesh S., Zuppa, Athena, Hwang, Wei-Ting, Christofidou-Solomidou, Melpo
Publicado 2021