Endocrine Regulation of Microvascular Receptor—Mediated Transcytosis and Its Therapeutic Opportunities: Insights by PCSK9—Mediated Regulation

por Mazura, Alexander D., Pietrzik, Claus U.
Publicado 2023

Mice are not Men: ADAM30 Findings Emphasize a Broader Look Towards Murine Alzheimer's Disease Models

por Becker-Pauly, Christoph, Pietrzik, Claus U.
Publicado 2016

The Metalloprotease Meprin β Is an Alternative β-Secretase of APP

por Becker-Pauly, Christoph, Pietrzik, Claus U.
Publicado 2017

Brain endothelial LRP1 maintains blood–brain barrier integrity

por Storck, Steffen E., Kurtyka, Magdalena, Pietrzik, Claus U.
Publicado 2021

Structure and Synaptic Function of Metal Binding to the Amyloid Precursor Protein and its Proteolytic Fragments

por Wild, Klemens, August, Alexander, Pietrzik, Claus U., Kins, Stefan
Publicado 2017

Presenilin Is the Molecular Target of Acidic γ-Secretase Modulators in Living Cells

por Jumpertz, Thorsten, Rennhack, Andreas, Ness, Julia, Baches, Sandra, Pietrzik, Claus U., Bulic, Bruno, Weggen, Sascha
Publicado 2012

LRP1 is critical for the surface distribution and internalization of the NR2B NMDA receptor subtype

por Maier, Wladislaw, Bednorz, Mariola, Meister, Sabrina, Roebroek, Anton, Weggen, Sascha, Schmitt, Ulrich, Pietrzik, Claus U
Publicado 2013

APP dimer formation is initiated in the endoplasmic reticulum and differs between APP isoforms

por Isbert, Simone, Wagner, Katja, Eggert, Simone, Schweitzer, Andrea, Multhaup, Gerd, Weggen, Sascha, Kins, Stefan, Pietrzik, Claus U.
Publicado 2011

PCSK9 acts as a key regulator of Aβ clearance across the blood–brain barrier

por Mazura, Alexander D., Ohler, Anke, Storck, Steffen E., Kurtyka, Magdalena, Scharfenberg, Franka, Weggen, Sascha, Becker-Pauly, Christoph, Pietrzik, Claus U.
Publicado 2022

Expression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic mice

por Steffen, Johannes, Krohn, Markus, Schwitlick, Christina, Brüning, Thomas, Paarmann, Kristin, Pietrzik, Claus U., Biverstål, Henrik, Jansone, Baiba, Langer, Oliver, Pahnke, Jens
Publicado 2017

Uptake Mechanism of ApoE-Modified Nanoparticles on Brain Capillary Endothelial Cells as a Blood-Brain Barrier Model

por Wagner, Sylvia, Zensi, Anja, Wien, Sascha L., Tschickardt, Sabrina E., Maier, Wladislaw, Vogel, Tikva, Worek, Franz, Pietrzik, Claus U., Kreuter, Jörg, von Briesen, Hagen
Publicado 2012

LRP1 Has a Predominant Role in Production over Clearance of Aβ in a Mouse Model of Alzheimer’s Disease

por Van Gool, Bart, Storck, Steffen E., Reekmans, Sara M., Lechat, Benoit, Gordts, Philip L. S. M., Pradier, Laurent, Pietrzik, Claus U., Roebroek, Anton J. M.
Publicado 2019

Is LRP2 Involved in Leptin Transport over the Blood-Brain Barrier and Development of Obesity?

por Sandin, Elvira S., Folberth, Julica, Müller-Fielitz, Helge, Pietrzik, Claus U., Herold, Elisabeth, Willnow, Thomas E., Pfluger, Paul T., Nogueiras, Ruben, Prevot, Vincent, Krey, Thomas, Schwaninger, Markus
Publicado 2021

Pathogenic Aβ production by heterozygous PSEN1 mutations is intrinsic to the mutant protein and not mediated by conformational hindrance of wild-type PSEN1

por Kurth, Vanessa, Ogorek, Isabella, Münch, Carolina, Lopez-Rios, Javier, Ousson, Solenne, Lehmann, Sandra, Nieweg, Katja, Roebroek, Anton J.M., Pietrzik, Claus U., Beher, Dirk, Weggen, Sascha
Publicado 2023

Adaptive responses of neuronal cells to chronic endoplasmic reticulum (ER) stress

por Pham, Thu Nguyen Minh, Perumal, Natarajan, Manicam, Caroline, Basoglu, Marion, Eimer, Stefan, Fuhrmann, Dominik C., Pietrzik, Claus U., Clement, Albrecht M., Körschgen, Hagen, Schepers, Jana, Behl, Christian
Publicado 2023

LRP1 Modulates APP Intraneuronal Transport and Processing in Its Monomeric and Dimeric State

por Herr, Uta-Mareike, Strecker, Paul, Storck, Steffen E., Thomas, Carolin, Rabiej, Verena, Junker, Anne, Schilling, Sandra, Schmidt, Nadine, Dowds, C. Marie, Eggert, Simone, Pietrzik, Claus U., Kins, Stefan
Publicado 2017

Generation of aggregation prone N-terminally truncated amyloid β peptides by meprin β depends on the sequence specificity at the cleavage site

por Schönherr, Caroline, Bien, Jessica, Isbert, Simone, Wichert, Rielana, Prox, Johannes, Altmeppen, Hermann, Kumar, Sathish, Walter, Jochen, Lichtenthaler, Stefan F., Weggen, Sascha, Glatzel, Markus, Becker-Pauly, Christoph, Pietrzik, Claus U.
Publicado 2016

The LepR-mediated leptin transport across brain barriers controls food reward

por Di Spiezio, Alessandro, Sandin, Elvira Sonia, Dore, Riccardo, Müller-Fielitz, Helge, Storck, Steffen E., Bernau, Mareike, Mier, Walter, Oster, Henrik, Jöhren, Olaf, Pietrzik, Claus U., Lehnert, Hendrik, Schwaninger, Markus
Publicado 2017

Meprin β knockout reduces brain Aβ levels and rescues learning and memory impairments in the APP/lon mouse model for Alzheimer’s disease

por Marengo, Liana, Armbrust, Fred, Schoenherr, Caroline, Storck, Steffen E., Schmitt, Ulrich, Zampar, Silvia, Wirths, Oliver, Altmeppen, Hermann, Glatzel, Markus, Kaether, Christoph, Weggen, Sascha, Becker-Pauly, Christoph, Pietrzik, Claus U.
Publicado 2022

Nanoparticulate flurbiprofen reduces amyloid-β(42) generation in an in vitro blood–brain barrier model

por Meister, Sabrina, Zlatev, Iavor, Stab, Julia, Docter, Dominic, Baches, Sandra, Stauber, Roland H, Deutsch, Mordechai, Schmidt, Reinhold, Ropele, Stefan, Windisch, Manfred, Langer, Klaus, Wagner, Sylvia, von Briesen, Hagen, Weggen, Sascha, Pietrzik, Claus U
Publicado 2013