Challenges and Opportunities in P450 Research on the Eye

por Pikuleva, Irina A.
Publicado 2023

Cholesterol Hydroxylating Cytochrome P450 46A1: From Mechanisms of Action to Clinical Applications

por Pikuleva, Irina A., Cartier, Nathalie
Publicado 2021

Increased Acetylcholine Levels and Other Brain Effects in 5XFAD Mice after Treatment with 8,14-Dihydroxy Metabolite of Efavirenz

por Mast, Natalia, Li, Yong, Pikuleva, Irina A.
Publicado 2022

Editorial: Cholesterol and Neurodegenerative Diseases - Pressing Questions and How to Address Them

por Betuing, Sandrine, Pikuleva, Irina A., Castellano, Joseph M.
Publicado 2022

Quantitative characterizations of the cholesterol-related pathways in the retina and brain of hamsters

por Mast, Natalia, El-Darzi, Nicole, Li, Yong, Pikuleva, Irina A.
Publicado 2023

Histone H3 Ser57 and Thr58 phosphorylation in the brain of 5XFAD mice

por Anderson, Kyle W., Mast, Natalia, Pikuleva, Irina A., Turko, Illarion V.
Publicado 2015

Brain sterol flux mediated by cytochrome P450 46A1 affects membrane properties and membrane-dependent processes

por Petrov, Alexey M, Mast, Natalia, Li, Young, Denker, John, Pikuleva, Irina A
Publicado 2020

Brain Acetyl-CoA Production and Phosphorylation of Cytoskeletal Proteins Are Targets of CYP46A1 Activity Modulation and Altered Sterol Flux

por Mast, Natalia, Petrov, Alexey M., Prendergast, Erin, Bederman, Ilya, Pikuleva, Irina A.
Publicado 2021

Transcriptional and post-translational changes in the brain of mice deficient in cholesterol removal mediated by cytochrome P450 46A1 (CYP46A1)

por Mast, Natalia, Lin, Joseph B., Anderson, Kyle W., Bjorkhem, Ingemar, Pikuleva, Irina A.
Publicado 2017

In Vitro Activation of Cytochrome P450 46A1 (CYP46A1) by Efavirenz-Related Compounds

por Mast, Natalia, Verwilst, Peter, Wilkey, Clayton J., Guengerich, F. Peter, Pikuleva, Irina A.
Publicado 2019

CYP46A1-dependent and independent effects of efavirenz treatment

por Mast, Natalia, El-Darzi, Nicole, Petrov, Alexey M, Li, Young, Pikuleva, Irina A
Publicado 2020

N,N-Dimethyl-3β-hydroxycholenamide Reduces Retinal Cholesterol via Partial Inhibition of Retinal Cholesterol Biosynthesis Rather Than its Liver X Receptor Transcriptional Activity

por El-Darzi, Nicole, Astafev, Artem, Mast, Natalia, Saadane, Aicha, Lam, Morrie, Pikuleva, Irina A.
Publicado 2018

Quantification of Histone Deacetylase Isoforms in Human Frontal Cortex, Human Retina, and Mouse Brain

por Anderson, Kyle W., Chen, Junjun, Wang, Meiyao, Mast, Natalia, Pikuleva, Irina A., Turko, Illarion V.
Publicado 2015

Use of complementary cation and anion heavy-atom salt derivatives to solve the structure of cytochrome P450 46A1

por White, Mark Andrew, Mast, Natalia, Bjorkhem, Ingemar, Johnson, Eric F., Stout, C. David, Pikuleva, Irina A.
Publicado 2008

The Interplay between Retinal Pathways of Cholesterol Output and Its Effects on Mouse Retina

por Petrov, Alexey M., Astafev, Artem A., Mast, Natalia, Saadane, Aicha, El-Darzi, Nicole, Pikuleva, Irina A.
Publicado 2019

Characterizations of Hamster Retina as a Model for Studies of Retinal Cholesterol Homeostasis

por El-Darzi, Nicole, Mast, Natalia, Dailey, Brian, Denker, John, Li, Yong, Vance, Joseph, Pikuleva, Irina A.
Publicado 2021

2-Hydroxypropyl-β-cyclodextrin mitigates pathological changes in a mouse model of retinal cholesterol dyshomeostasis

por El-Darzi, Nicole, Mast, Natalia, Hammer, Sandra S., Dorweiler, Tim F., Busik, Julia V., Pikuleva, Irina A.
Publicado 2022

The normalizing effects of the CYP46A1 activator efavirenz on retinal sterol levels and risk factors for glaucoma in Apoj(−/−) mice

por El-Darzi, Nicole, Mast, Natalia, Li, Yong, Dailey, Brian, Kang, Min, Rhee, Douglas J., Pikuleva, Irina A.
Publicado 2023

Low-Dose Anti-HIV Drug Efavirenz Mitigates Retinal Vascular Lesions in a Mouse Model of Alzheimer’s Disease

por El-Darzi, Nicole, Mast, Natalia, Buchner, David A., Saadane, Aicha, Dailey, Brian, Trichonas, Georgios, Pikuleva, Irina A.
Publicado 2022

Spatial Distribution of the Pathways of Cholesterol Homeostasis in Human Retina

por Zheng, Wenchao, Reem, Rachel E., Omarova, Saida, Huang, Suber, DiPatre, Pier Luigi, Charvet, Casey D., Curcio, Christine A., Pikuleva, Irina A.
Publicado 2012