Therapeutic Potential of Targeting Plasminogen Activator Inhibitor-1 in COVID-19

por Kellici, Tahsin F., Pilka, Ewa S., Bodkin, Michael J.
Publicado 2021

Hydrophobicity of protein determinants influences the recognition of substrates by EDEM1 and EDEM2 in human cells

por Sokołowska, Iwona, Piłka, Ewa S, Sandvig, Kirsten, Węgrzyn, Grzegorz, Słomińska-Wojewódzka, Monika
Publicado 2015

Insight into S-adenosylmethionine biosynthesis from the crystal structures of the human methionine adenosyltransferase catalytic and regulatory subunits

por Shafqat, Naeem, Muniz, Joao R. C., Pilka, Ewa S., Papagrigoriou, Evangelos, vonDelft, Frank, Oppermann, Udo, Yue, Wyatt W.
Publicado 2013

Structure of human aspartyl aminopeptidase complexed with substrate analogue: insight into catalytic mechanism, substrate specificity and M18 peptidase family

por Chaikuad, Apirat, Pilka, Ewa S, De Riso, Antonio, von Delft, Frank, Kavanagh, Kathryn L, Vénien-Bryan, Catherine, Oppermann, Udo, Yue, Wyatt W
Publicado 2012

Structural Basis for Substrate Specificity in Human Monomeric Carbonyl Reductases

por Pilka, Ewa S., Niesen, Frank H., Lee, Wen Hwa, El-Hawari, Yasser, Dunford, James E., Kochan, Grazyna, Wsol, Vladimir, Martin, Hans-Joerg, Maser, Edmund, Oppermann, Udo
Publicado 2009

High-Affinity Inhibitors of Human NAD(+)-Dependent 15-Hydroxyprostaglandin Dehydrogenase: Mechanisms of Inhibition and Structure-Activity Relationships

por Niesen, Frank H., Schultz, Lena, Jadhav, Ajit, Bhatia, Chitra, Guo, Kunde, Maloney, David J., Pilka, Ewa S., Wang, Minghua, Oppermann, Udo, Heightman, Tom D., Simeonov, Anton
Publicado 2010

Structural and Biochemical Studies of a Moderately Thermophilic Exonuclease I from Methylocaldum szegediense

por Fei, Li, Tian, SiSi, Moysey, Ruth, Misca, Mihaela, Barker, John J., Smith, Myron A., McEwan, Paul A., Pilka, Ewa S., Crawley, Lauren, Evans, Tom, Sun, Dapeng
Publicado 2015

The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using en...

por Tsoumpra, Maria K., Muniz, Joao R., Barnett, Bobby L., Kwaasi, Aaron A., Pilka, Ewa S., Kavanagh, Kathryn L., Evdokimov, Artem, Walter, Richard L., Von Delft, Frank, Ebetino, Frank H., Oppermann, Udo, Russell, R. Graham G., Dunford, James E.
Publicado 2015

Ribosomal Oxygenases are Structurally Conserved from Prokaryotes to Humans

por Chowdhury, Rasheduzzaman, Sekirnik, Rok, Brissett, Nigel C., Krojer, Tobias, Ho, Chia-hua, Ng, Stanley S., Clifton, Ian J., Ge, Wei, Kershaw, Nadia J., Fox, Gavin C., Muniz, Joao R. C., Vollmar, Melanie, Phillips, Claire, Pilka, Ewa S., Kavanagh, Kathryn L., von Delft, Frank, Oppermann, Udo, McDonough, Michael A., Doherty, Aiden J., Schofield, Christopher J.
Publicado 2014

Crystal Structures of Malonyl-Coenzyme A Decarboxylase Provide Insights into Its Catalytic Mechanism and Disease-Causing Mutations

por Froese, D. Sean, Forouhar, Farhad, Tran, Timothy H., Vollmar, Melanie, Kim, Yi Seul, Lew, Scott, Neely, Helen, Seetharaman, Jayaraman, Shen, Yang, Xiao, Rong, Acton, Thomas B., Everett, John K., Cannone, Giuseppe, Puranik, Sriharsha, Savitsky, Pavel, Krojer, Tobias, Pilka, Ewa S., Kiyani, Wasim, Lee, Wen Hwa, Marsden, Brian D., von Delft, Frank, Allerston, Charles K., Spagnolo, Laura, Gileadi, Opher, Montelione, Gaetano T., Oppermann, Udo, Yue, Wyatt W., Tong, Liang
Publicado 2013