Development, Verification, and Prediction of Osimertinib Drug–Drug Interactions Using PBPK Modeling Approach to Inform Drug Label

por Pilla Reddy, Venkatesh, Walker, Michael, Sharma, Pradeep, Ballard, Peter, Vishwanathan, Karthick
Publicado 2018

Physiologically Based Pharmacokinetic Modeling for Olaparib Dosing Recommendations: Bridging Formulations, Drug Interactions, and Patient Populations

por Pilla Reddy, Venkatesh, Bui, Khanh, Scarfe, Graeme, Zhou, Diansong, Learoyd, Maria
Publicado 2018

Unraveling pleiotropic effects of rifampicin by using physiologically based pharmacokinetic modeling: Assessing the induction magnitude of P‐glycoprotein–cytochrome P450 3A4 dual s...

por Pan, Xian, Yamazaki, Shinji, Neuhoff, Sibylle, Zhang, Mian, Pilla Reddy, Venkatesh
Publicado 2021

Model‐Informed Pediatric Dose Selection for Dapagliflozin by Incorporating Developmental Changes

por Jo, Heeseung, Pilla Reddy, Venkatesh, Parkinson, Joanna, Boulton, David W., Tang, Weifeng
Publicado 2021

Development of and insights from systems pharmacology models of antibody‐drug conjugates

por Lam, Inez, Pilla Reddy, Venkatesh, Ball, Kathryn, Arends, Rosalinda H., Mac Gabhann, Feilim
Publicado 2022

Harnessing Clinical Trial and Real-World Data Towards an Understanding of Sex Effects on Drug Pharmacokinetics, Pharmacodynamics and Efficacy

por Oi Yan Chan, Joyce, Moullet, Marie, Williamson, Beth, Arends, Rosalinda H., Pilla Reddy, Venkatesh
Publicado 2022

Comparing the applications of machine learning, PBPK, and population pharmacokinetic models in pharmacokinetic drug–drug interaction prediction

por Gill, Jaidip, Moullet, Marie, Martinsson, Anton, Miljković, Filip, Williamson, Beth, Arends, Rosalinda H., Pilla Reddy, Venkatesh
Publicado 2022

Evaluating the performance of machine‐learning regression models for pharmacokinetic drug–drug interactions

por Gill, Jaidip, Moullet, Marie, Martinsson, Anton, Miljković, Filip, Williamson, Beth, Arends, Rosalinda H., Pilla Reddy, Venkatesh
Publicado 2022

Mechanistic physiology-based pharmacokinetic modeling to elucidate vincristine-induced peripheral neuropathy following treatment with novel kinase inhibitors

por Pilla Reddy , Venkatesh, Fretland, Adrian J., Zhou, Diansong, Sharma, Shringi, Chen, Buyun, Vishwanathan, Karthick, McGinnity, Dermot F., Xu, Yan, Ware, Joseph A.
Publicado 2021

Mechanism-Based Pharmacokinetic–Pharmacodynamic Modeling of the Dopamine D(2) Receptor Occupancy of Olanzapine in Rats

por Johnson, Martin, Kozielska, Magdalena, Pilla Reddy, Venkatesh, Vermeulen, An, Li, Cheryl, Grimwood, Sarah, de Greef, Rik, Groothuis, Geny M. M., Danhof, Meindert, Proost, Johannes H.
Publicado 2011

Pharmacokinetic-Pharmacodynamic Modeling of the D(2) and 5-HT(2A) Receptor Occupancy of Risperidone and Paliperidone in Rats

por Kozielska, Magdalena, Johnson, Martin, Pilla Reddy, Venkatesh, Vermeulen, An, Li, Cheryl, Grimwood, Sarah, de Greef, Rik, Groothuis, Geny M. M., Danhof, Meindert, Proost, Johannes H.
Publicado 2012

Erratum to: Translational Modeling in Schizophrenia: Predicting Human Dopamine D(2) Receptor Occupancy

por Johnson, Martin, Kozielska, Magdalena, Pilla Reddy, Venkatesh, Vermeulen, An, Barton, Hugh A., Grimwood, Sarah, de Greef, Rik, Groothuis, Geny M. M., Danhof, Meindert, Proost, Johannes H.
Publicado 2016

Tumour-on-chip microfluidic platform for assessment of drug pharmacokinetics and treatment response

por Petreus, Tudor, Cadogan, Elaine, Hughes, Gareth, Smith, Aaron, Pilla Reddy, Venkatesh, Lau, Alan, O’Connor, Mark James, Critchlow, Susan, Ashford, Marianne, Oplustil O’Connor, Lenka
Publicado 2021

Interlaboratory Variability in the Madin–Darby Canine Kidney Cell Proteome

por Harwood, Matthew D., Zettl, Katharina, Weinheimer, Manuel, Pilla-Reddy, Venkatesh, Shen, Hong, Jacobs, Frank, Chu, Xiaoyan, Huth, Felix, Nakakariya, Masanori, Chothe, Paresh P., Neuhoff, Sibylle, Wiśniewski, Jacek R.
Publicado 2023

Asenapine pharmacokinetics and tolerability in a pediatric population

por Dogterom, Peter, Riesenberg, Robert, de Greef, Rik, Dennie, Justin, Johnson, Martin, Pilla Reddy, Venkatesh, Miltenburg, André MM, Findling, Robert L, Jakate, Abhijeet, Carrothers, Timothy J, Troyer, Matthew D
Publicado 2018

Pediatric Pharmacokinetics and Dose Predictions: A Report of a Satellite Meeting to the 10th Juvenile Toxicity Symposium

por van Groen, Bianca D., Pilla Reddy, Venkatesh, Badée, Justine, Olivares‐Morales, Andrés, Johnson, Trevor N., Nicolaï, Johan, Annaert, Pieter, Smits, Anne, de Wildt, Saskia N., Knibbe, Catherijne A. J., de Zwart, Loeckie
Publicado 2020

Safety, Tolerability and Pharmacokinetics of Half-Life Extended Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Monoclonal Antibodies AZD7442 (Tixagevimab-Cilgavimab)...

por Forte-Soto, Pablo, Albayaty, Muna, Brooks, Dennis, Arends, Rosalinda H, Tillinghast, John, Aksyuk, Anastasia A, Bouquet, Jerome, Chen, Cecil, Gebre, Asfiha, Kubiak, Robert J, Pilla Reddy, Venkatesh, Seegobin, Seth, Streicher, Katie, Templeton, Alison, Esser, Mark T
Publicado 2023

Comparative Pharmacokinetics of Tixagevimab/Cilgavimab (AZD7442) Administered Intravenously Versus Intramuscularly in Symptomatic SARS‐CoV‐2 Infection

por Bender Ignacio, Rachel A., Wohl, David A., Arends, Rosalin, Pilla Reddy, Venkatesh, Mu, Ying, Javan, Arzhang Cyrus, Hughes, Michael D., Eron, Joseph J., Currier, Judith S., Smith, Davey, Chew, Kara W., Gibbs, Michael, Fletcher, Courtney V.
Publicado 2022

Physiologically‐Based Pharmacokinetic Models for Evaluating Membrane Transporter Mediated Drug–Drug Interactions: Current Capabilities, Case Studies, Future Opportunities, and Reco...

por Taskar, Kunal S., Pilla Reddy, Venkatesh, Burt, Howard, Posada, Maria M., Varma, Manthena, Zheng, Ming, Ullah, Mohammed, Emami Riedmaier, Arian, Umehara, Ken‐ichi, Snoeys, Jan, Nakakariya, Masanori, Chu, Xiaoyan, Beneton, Maud, Chen, Yuan, Huth, Felix, Narayanan, Rangaraj, Mukherjee, Dwaipayan, Dixit, Vaishali, Sugiyama, Yuichi, Neuhoff, Sibylle
Publicado 2019