PRRX1 isoforms cooperate with FOXM1 to regulate the DNA damage response in pancreatic cancer cells

por Marchand, Benoît, Pitarresi, Jason R., Reichert, Maximilian, Suzuki, Kensuke, Laczkó, Dorottya, Rustgi, Anil K.
Publicado 2019

Growth of pancreatic cancers with hemizygous chromosomal 17p loss of MYBBP1A can be preferentially targeted by PARP inhibitors

por Hsieh, Antony, Pitarresi, Jason R., Lerner, Jonathan, Donahue, Greg, Hsiehchen, David, Rustgi, Anil K., Zaret, Kenneth
Publicado 2020

Murine models for familial pancreatic cancer: Histopathology, latency and drug sensitivity among cancers of Palb2, Brca1 and Brca2 mutant mouse strains

por Park, Dongju, Shakya, Reena, Koivisto, Christopher, Pitarresi, Jason R., Szabolcs, Matthias, Kladney, Raleigh, Hadjis, Ashley, Mace, Thomas A., Ludwig, Thomas
Publicado 2019

Pharmacologic Activation of the G Protein–Coupled Estrogen Receptor Inhibits Pancreatic Ductal Adenocarcinoma

por Natale, Christopher A., Li, Jinyang, Pitarresi, Jason R., Norgard, Robert J., Dentchev, Tzvete, Capell, Brian C., Seykora, John T., Stanger, Ben Z., Ridky, Todd W.
Publicado 2020

The mitochondrial Ca(2+) channel MCU is critical for tumor growth by supporting cell cycle progression and proliferation

por García, Emily Fernández, Paudel, Usha, Noji, Michael C., Bowman, Caitlyn E., Pitarresi, Jason R., Rustgi, Anil K., Wellen, Kathryn E., Arany, Zolt, Weissenrieder, Jillian S., Foskett, J. Kevin
Publicado 2023

The mitochondrial Ca(2+) channel MCU is critical for tumor growth by supporting cell cycle progression and proliferation

por Fernandez Garcia, Emily, Paudel, Usha, Noji, Michael C., Bowman, Caitlyn E., Rustgi, Anil K., Pitarresi, Jason R., Wellen, Kathryn E., Arany, Zolt, Weissenrieder, Jillian S., Foskett, J. Kevin
Publicado 2023

Anti-IL-6 and PD-L1 antibody combination therapy reduces tumor progression in murine models of pancreatic cancer

por Mace, Thomas, Shakya, Reena, Pitarresi, Jason, Loftus, Shannon, Swanson, Benjamin, Young, Gregory, Zhong, Xioling, Zimmers, Teresa, Ostrowski, Michael, Ludwig, Thomas, Bloomston, Mark, Bekaii-Saab, Tanios, Lesinski, Gregory
Publicado 2015

Protein Kinase C Beta in the Tumor Microenvironment Promotes Mammary Tumorigenesis

por Wallace, Julie A., Pitarresi, Jason R., Sharma, Nandini, Palettas, Marilly, Cuitiño, Maria C., Sizemore, Steven T., Yu, Lianbo, Sanderlin, Allen, Rosol, Thomas J., Mehta, Kamal D., Sizemore, Gina M., Ostrowski, Michael C.
Publicado 2014

Single agent BMS-911543 Jak2 inhibitor has distinct inhibitory effects on STAT5 signaling in genetically engineered mice with pancreatic cancer

por Mace, Thomas A., Shakya, Reena, Elnaggar, Omar, Wilson, Kristin, Komar, Hannah M., Yang, Jennifer, Pitarresi, Jason R., Young, Gregory S., Ostrowski, Michael C., Ludwig, Thomas, Bekaii-Saab, Tanios, Bloomston, Mark, Lesinski, Gregory B.
Publicado 2015

Generation of a pancreatic cancer model using a Pdx1-Flp recombinase knock-in allele

por Wu, Jinghai, Liu, Xin, Nayak, Sunayana G., Pitarresi, Jason R., Cuitiño, Maria C., Yu, Lianbo, Hildreth, Blake E., Thies, Katie A., Schilling, Daniel J., Fernandez, Soledad A., Leone, Gustavo, Ostrowski, Michael C.
Publicado 2017

Nanoparticle delivery of innate immune agonists combines with senescence-inducing agents to mediate T cell control of pancreatic cancer

por Chibaya, Loretah, Lusi, Christina F., DeMarco, Kelly D., Kane, Griffin I., Brassil, Meghan L., Parikh, Chaitanya N., Murphy, Katherine C., Li, Junhui, Naylor, Tiana E., Cerrutti, Julia, Peura, Jessica, Pitarresi, Jason R., Zhu, Lihua Julie, Fitzgerald, Katherine A., Atukorale, Prabhani U., Ruscetti, Marcus
Publicado 2023

Patient-derived organoids as a platform for modeling a patient’s response to chemoradiotherapy in esophageal cancer

por Karakasheva, Tatiana A., Gabre, Joel T., Sachdeva, Uma M., Cruz-Acuña, Ricardo, Lin, Eric W., DeMarshall, Maureen, Falk, Gary W., Ginsberg, Gregory G., Yang, Zhaohai, Kim, Michele M., Diffenderfer, Eric S., Pitarresi, Jason R., Li, Jinyang, Muir, Amanda B., Hamilton, Kathryn E., Nakagawa, Hiroshi, Bass, Adam J., Rustgi, Anil K.
Publicado 2021

The LIN28B–IMP1 post-transcriptional regulon has opposing effects on oncogenic signaling in the intestine

por Chatterji, Priya, Hamilton, Kathryn E., Liang, Shun, Andres, Sarah F., Wijeratne, H.R. Sagara, Mizuno, Rei, Simon, Lauren A., Hicks, Philip D., Foley, Shawn W., Pitarresi, Jason R., Klein-Szanto, Andres J., Mah, Amanda T., Van Landeghem, Laurianne, Gregory, Brian D., Lengner, Christopher J., Madison, Blair B., Shah, Premal, Rustgi, Anil K.
Publicado 2018

Mutant p53 regulates Survivin to foster lung metastasis

por Tang, Qiaosi, Efe, Gizem, Chiarella, Anna M., Leung, Jessica, Chen, Maoting, Yamazoe, Taiji, Su, Zhenyi, Pitarresi, Jason R., Li, Jinyang, Islam, Mirazul, Karakasheva, Tatiana, Klein-Szanto, Andres J., Pan, Samuel, Hu, Jianhua, Natsugoe, Shoji, Gu, Wei, Stanger, Ben Z., Wong, Kwok-K, Diehl, J. Alan, Bass, Adam J., Nakagawa, Hiroshi, Murphy, Maureen E., Rustgi, Anil K.
Publicado 2021

Phase Ib and Expansion Study of Gemcitabine, Nab-Paclitaxel, and Ficlatuzumab in Patients With Metastatic Pancreatic Cancer

por Perez, Kimberly, Chiarella, Anna M, Cleary, James M, Horick, Nora, Weekes, Colin, Abrams, Thomas, Blaszkowsky, Lawrence, Enzinger, Peter, Giannakis, Marios, Goyal, Lipika, Meyerhardt, Jeffrey A, Rubinson, Douglas, Yurgelun, Matthew B, Goessling, Wolfram, Giantonio, Bruce J, Brais, Lauren, Germon, Victoria, Stonely, Danielle, Raghavan, Srivatsan, Bakir, Basil, Das, Koushik, Pitarresi, Jason R, Aguirre, Andrew J, Needle, Michael, Rustgi, Anil K, Wolpin, Brian M
Publicado 2023

Stromal ETS2 Regulates Chemokine Production and Immune Cell Recruitment during Acinar-to-Ductal Metaplasia()

por Pitarresi, Jason R., Liu, Xin, Sharma, Sudarshana M., Cuitiño, Maria C., Kladney, Raleigh D., Mace, Thomas A., Donohue, Sydney, Nayak, Sunayana G., Qu, Chunjing, Lee, James, Woelke, Sarah A., Trela, Stefan, LaPak, Kyle, Yu, Lianbo, McElroy, Joseph, Rosol, Thomas J., Shakya, Reena, Ludwig, Thomas, Lesinski, Gregory B., Fernandez, Soledad A., Konieczny, Stephen F., Leone, Gustavo, Wu, Jinghai, Ostrowski, Michael C.
Publicado 2016

Genetic ablation of Smoothened in pancreatic fibroblasts increases acinar–ductal metaplasia

por Liu, Xin, Pitarresi, Jason R., Cuitiño, Maria C., Kladney, Raleigh D., Woelke, Sarah A., Sizemore, Gina M., Nayak, Sunayana G., Egriboz, Onur, Schweickert, Patrick G., Yu, Lianbo, Trela, Stefan, Schilling, Daniel J., Halloran, Shannon K., Li, Maokun, Dutta, Shourik, Fernandez, Soledad A., Rosol, Thomas J., Lesinski, Gregory B., Shakya, Reena, Ludwig, Thomas, Konieczny, Stephen F., Leone, Gustavo, Wu, Jinghai, Ostrowski, Michael C.
Publicado 2016

STAT3 in tumor fibroblasts promotes an immunosuppressive microenvironment in pancreatic cancer

por Lefler, Julia E, MarElia-Bennett, Catherine B, Thies, Katie A, Hildreth, Blake E, Sharma, Sudarshana M, Pitarresi, Jason R, Han, Lu, Everett, Caroline, Koivisto, Christopher, Cuitino, Maria C, Timmers, Cynthia D, O’Quinn, Elizabeth, Parrish, Melodie, Romeo, Martin J, Linke, Amanda J, Hobbs, G Aaron, Leone, Gustavo, Guttridge, Denis C, Zimmers, Teresa A, Lesinski, Gregory B, Ostrowski, Michael C
Publicado 2022

MYC Levels Regulate Metastatic Heterogeneity in Pancreatic Adenocarcinoma

por Maddipati, Ravikanth, Norgard, Robert J., Baslan, Timour, Rathi, Komal S., Zhang, Amy, Saeid, Asal, Higashihara, Taku, Wu, Feng, Kumar, Angad, Annamalai, Valli, Bhattacharya, Saurav, Raman, Pichai, Adkisson, Christian A., Pitarresi, Jason R., Wengyn, Maximilian D., Yamazoe, Taiji, Li, Jinyang, Balli, David, LaRiviere, Michael J., Ngo, Tuong-Vi C., Folkert, Ian W., Millstein, Ian D., Bermeo, Jonathan, Carpenter, Erica L., McAuliffe, John C., Oktay, Maja H., Brekken, Rolf A., Lowe, Scott W., Iacobuzio-Donahue, Christine A., Notta, Faiyaz, Stanger, Ben Z.
Publicado 2022

Disruption of stromal hedgehog signaling initiates RNF5-mediated proteasomal degradation of PTEN and accelerates pancreatic tumor growth

por Pitarresi, Jason R, Liu, Xin, Avendano, Alex, Thies, Katie A, Sizemore, Gina M, Hammer, Anisha M, Hildreth, Blake E, Wang, David J, Steck, Sarah A, Donohue, Sydney, Cuitiño, Maria C, Kladney, Raleigh D, Mace, Thomas A, Chang, Jonathan J, Ennis, Christina S, Li, Huiqing, Reeves, Roger H, Blackshaw, Seth, Zhang, Jianying, Yu, Lianbo, Fernandez, Soledad A, Frankel, Wendy L, Bloomston, Mark, Rosol, Thomas J, Lesinski, Gregory B, Konieczny, Stephen F, Guttridge, Denis C, Rustgi, Anil K, Leone, Gustavo, Song, Jonathan W, Wu, Jinghai, Ostrowski, Michael C
Publicado 2018