Modulating Enzyme Function via Dynamic Allostery within Biliverdin Reductase B

por Redzic, Jasmina S., Duff, Michael R., Blue, Ashley, Pitts, Todd M., Agarwal, Pratul, Eisenmesser, Elan Zohar
Publicado 2021

Utilization of Quantitative In Vivo Pharmacology Approaches to Assess Combination Effects of Everolimus and Irinotecan in Mouse Xenograft Models of Colorectal Cancer

por Bradshaw-Pierce, Erica L., Pitts, Todd M., Kulikowski, Gillian, Selby, Heather, Merz, Andrea L., Gustafson, Daniel L., Serkova, Natalie J., Eckhardt, S. Gail, Weekes, Colin D.
Publicado 2013

A Phase I Dose‐Escalation Study of Linsitinib (OSI‐906), a Small‐Molecule Dual Insulin‐Like Growth Factor‐1 Receptor/Insulin Receptor Kinase Inhibitor, in Combination with Irinotec...

por Davis, S. Lindsey, Eckhardt, S. Gail, Diamond, Jennifer R., Messersmith, Wells A., Dasari, Arvind, Weekes, Colin D., Lieu, Christopher H., Kane, Madeline, Choon Tan, Aik, Pitts, Todd M., Leong, Stephen
Publicado 2018

Efficacy and Molecular Mechanisms of Differentiated Response to the Aurora and Angiogenic Kinase Inhibitor ENMD-2076 in Preclinical Models of p53-Mutated Triple-Negative Breast Can...

por Ionkina, Anastasia A., Tentler, John J., Kim, Jihye, Capasso, Anna, Pitts, Todd M., Ryall, Karen A., Howison, Rebekah R., Kabos, Peter, Sartorius, Carol A., Tan, Aik Choon, Eckhardt, S. Gail, Diamond, Jennifer R.
Publicado 2017

An integrated bioinformatics analysis to dissect kinase dependency in triple negative breast cancer

por Ryall, Karen A, Kim, Jihye, Klauck, Peter J, Shin, Jimin, Yoo, Minjae, Ionkina, Anastasia, Pitts, Todd M, Tentler, John J, Diamond, Jennifer R, Eckhardt, S Gail, Heasley, Lynn E, Kang, Jaewoo, Tan, Aik Choon
Publicado 2015

Wee1 Inhibition Enhances the Anti-Tumor Effects of Capecitabine in Preclinical Models of Triple-Negative Breast Cancer

por Pitts, Todd M., Simmons, Dennis M., Bagby, Stacey M., Hartman, Sarah J., Yacob, Betelehem W., Gittleman, Brian, Tentler, John J., Cittelly, Diana, Ormond, D. Ryan, Messersmith, Wells A., Eckhardt, S. Gail, Diamond, Jennifer R.
Publicado 2020

Tumor P-Glycoprotein Correlates with Efficacy of PF-3758309 in in vitro and in vivo Models of Colorectal Cancer

por Bradshaw-Pierce, Erica Lynn, Pitts, Todd M., Tan, Aik-Choon, McPhillips, Kelly, West, Mark, Gustafson, Daniel L., Halsey, Charles, Nguyen, Leslie, Lee, Nathan V., Kan, Julie L. C., Murray, Brion William, Eckhardt, S. Gail
Publicado 2013

Evaluation of the efficacy of dasatinib, a Src/Abl inhibitor, in colorectal cancer cell lines and explant mouse model

por Scott, Aaron J., Song, Eun-Kee, Bagby, Stacey, Purkey, Alicia, McCarter, Martin, Gajdos, Csaba, Quackenbush, Kevin S., Cross, Benjamin, Pitts, Todd M., Tan, Aik Choon, Eckhardt, S. Gail, Fenton, Hubert, Arcaroli, John, Messersmith, Wells A.
Publicado 2017

Dual compartmental targeting of cell cycle and angiogenic kinases in colorectal cancer models

por Capasso, Anna, Pitts, Todd M., Klauck, Peter J., Bagby, Stacey M., Westbrook, Lindsey, Kaplan, Jeffrey, Soleimani, Milad, Spreafico, Anna, Tentler, John J., Diamond, Jennifer R., Arcaroli, John J., Messersmith, Wells A., Eckhardt, Sue G., Leong, Stephen
Publicado 2018

Antitumor activity of a potent MEK inhibitor, TAK-733, against colorectal cancer cell lines and patient derived xenografts

por Lieu, Christopher H., Klauck, Peter J., Henthorn, Patrick K., Tentler, John J., Tan, Aik-Choon, Spreafico, Anna, Selby, Heather M., Britt, Blair C., Bagby, Stacey M., Arcaroli, John J., Messersmith, Wells A., Pitts, Todd M., Eckhardt, S. Gail
Publicado 2015

WEE1 Inhibition in Combination With Targeted Agents and Standard Chemotherapy in Preclinical Models of Pancreatic Ductal Adenocarcinoma

por Hartman, Sarah J., Bagby, Stacey M., Yacob, Betelehem W., Simmons, Dennis M., MacBeth, Morgan, Lieu, Christopher H., Davis, S. Lindsey, Leal, Alexis D., Tentler, John J., Diamond, Jennifer R., Eckhardt, S. Gail, Messersmith, Wells A., Pitts, Todd M.
Publicado 2021

RX-5902, a novel β-catenin modulator, potentiates the efficacy of immune checkpoint inhibitors in preclinical models of triple-negative breast Cancer

por Tentler, John J., Lang, Julie, Capasso, Anna, Kim, Deog Joong, Benaim, Ely, Lee, Young B., Eisen, Andrew, Bagby, Stacey M., Hartman, Sarah J., Yacob, Betelehem W., Gittleman, Brian, Pitts, Todd M., Pelanda, Roberta, Eckhardt, S. Gail, Diamond, Jennifer R.
Publicado 2020

Dual Pharmacological Targeting of the MAP Kinase and PI3K/mTOR Pathway in Preclinical Models of Colorectal Cancer

por Pitts, Todd M., Newton, Timothy P., Bradshaw-Pierce, Erica L., Addison, Rebecca, Arcaroli, John J., Klauck, Peter J., Bagby, Stacey M., Hyatt, Stephanie L., Purkey, Alicia, Tentler, John J., Tan, Aik Choon, Messersmith, Wells A., Eckhardt, S. Gail, Leong, Stephen
Publicado 2014

The novel tankyrase inhibitor (AZ1366) enhances irinotecan activity in tumors that exhibit elevated tankyrase and irinotecan resistance

por Quackenbush, Kevin S., Bagby, Stacey, Tai, Wai Meng, Messersmith, Wells A., Schreiber, Anna, Greene, Justin, Kim, Jihye, Wang, Guoliang, Purkey, Alicia, Pitts, Todd M., Nguyen, Anna, Gao, Dexiang, Blatchford, Patrick, Capasso, Anna, Schuller, Alwin G., Eckhardt, S. Gail, Arcaroli, John J.
Publicado 2016

The novel ATM inhibitor (AZ31) enhances antitumor activity in patient derived xenografts that are resistant to irinotecan monotherapy

por Greene, Justin, Nguyen, Anna, Bagby, Stacey M., Jones, Gemma N., Tai, WM., Quackenbush, Kevin S., Schreiber, Anna, Messersmith, Wells A., Devaraj, Kalpana M., Blatchford, Patrick, Eckhardt, S. Gail, Cadogan, Elaine B., Hughes, Gareth D., Smith, Aaron, Pitts, Todd M., Arcaroli, John J.
Publicado 2017

Antitumor activity of the polo-like kinase inhibitor, TAK-960, against preclinical models of colorectal cancer

por Klauck, Peter J., Bagby, Stacey M., Capasso, Anna, Bradshaw-Pierce, Erica L., Selby, Heather M., Spreafico, Anna, Tentler, John J., Tan, Aik Choon, Kim, Jihye, Arcaroli, John J., Purkey, Alicia, Messersmith, Wells A., Kuida, Keisuke, Gail Eckhardt, S., Pitts, Todd M.
Publicado 2018

ATM kinase inhibitor AZD0156 in combination with irinotecan and 5-fluorouracil in preclinical models of colorectal cancer

por Davis, S. Lindsey, Hartman, Sarah J., Bagby, Stacey M., Schlaepfer, Marina, Yacob, Betelehem W., Tse, Tonia, Simmons, Dennis M., Diamond, Jennifer R., Lieu, Christopher H., Leal, Alexis D., Cadogan, Elaine B., Hughes, Gareth D., Durant, Stephen T., Messersmith, Wells A., Pitts, Todd M.
Publicado 2022

Pancreatic Ductal Adenocarcinoma Cells Regulate NLRP3 Activation to Generate a Tolerogenic Microenvironment

por Amo-Aparicio, Jesus, Dominguez, Adrian, Atif, Shaikh M., Dinarello, Alberto, Azam, Tania, Alula, Kibrom M., Piper, Miles, Lieu, Christopher H., Lentz, Robert W., Leal, Alexis D., Bagby, Stacey M., Messersmith, Wells A., Karam, Sana D., Dinarello, Charles A., Pitts, Todd M., Marchetti, Carlo
Publicado 2023

Combined inhibition of MEK and Aurora A kinase in KRAS/PIK3CA double-mutant colorectal cancer models

por Davis, S. Lindsey, Robertson, Kelli M., Pitts, Todd M., Tentler, John J., Bradshaw-Pierce, Erica L., Klauck, Peter J., Bagby, Stacey M., Hyatt, Stephanie L., Selby, Heather M., Spreafico, Anna, Ecsedy, Jeffrey A., Arcaroli, John J., Messersmith, Wells A., Tan, Aik Choon, Eckhardt, S. Gail
Publicado 2015

Association of the epithelial-to-mesenchymal transition phenotype with responsiveness to the p21-activated kinase inhibitor, PF-3758309, in colon cancer models

por Pitts, Todd M., Kulikowski, Gillian N., Tan, Aik-Choon, Murray, Brion W., Arcaroli, John J., Tentler, John J., Spreafico, Anna, Selby, Heather M., Kachaeva, Maria I., McPhillips, Kelly L., Britt, Blair C., Bradshaw-Pierce, Erica L., Messersmith, Wells A., Varella-Garcia, Marileila, Eckhardt, S. Gail
Publicado 2013