SYST-25 MICROGLIA-SECRETED LIPID SPECIES DRIVE GLIOMA INVASION

por Pallares-Moratalla, Carla, Guyot, Mélanie, Weng, Linqian, Planque, Melanie, Fendt, Sarah-Maria, Swinnen, Johan, Lambrechts, Diether, Bergers, Gabriele
Publicado 2023

Author Correction: CD40 signal rewires fatty acid and glutamine metabolism for stimulating macrophage anti-tumorigenic functions

por Liu, Pu-Ste, Chen, Yi-Ting, Li, Xiaoyun, Hsueh, Pei-Chun, Tzeng, Sheue-Fen, Chen, Hsi, Shi, Pei-Zhu, Xie, Xin, Parik, Sweta, Planque, Mélanie, Fendt, Sarah-Maria, Ho, Ping-Chih
Publicado 2023

CD40 signal rewires fatty acid and glutamine metabolism for stimulating macrophage anti-tumorigenic functions

por Liu, Pu-Ste, Chen, Yi-Ting, Li, Xiaoyun, Hsueh, Pei-Chun, Tzeng, Sheue-Fen, Chen, Hsi, Shi, Pei-Zhu, Xie, Xin, Parik, Sweta, Planque, Mélanie, Fendt, Sarah-Maria, Ho, Ping-Chih
Publicado 2023

mTOR Signaling and SREBP Activity Increase FADS2 Expression and Can Activate Sapienate Biosynthesis

por Triki, Mouna, Rinaldi, Gianmarco, Planque, Melanie, Broekaert, Dorien, Winkelkotte, Alina M., Maier, Carina R., Janaki Raman, Sudha, Vandekeere, Anke, Van Elsen, Joke, Orth, Martin F., Grünewald, Thomas G.P., Schulze, Almut, Fendt, Sarah-Maria
Publicado 2020

Combining the antianginal drug perhexiline with chemotherapy induces complete pancreatic cancer regression in vivo

por Reyes-Castellanos, Gabriela, Abdel Hadi, Nadine, Gallardo-Arriaga, Scarlett, Masoud, Rawand, Garcia, Julie, Lac, Sophie, El Kaoutari, Abdessamad, Gicquel, Tristan, Planque, Mélanie, Fendt, Sarah-Maria, Linares, Laetitia Karine, Gayet, Odile, Guillaumond, Fabienne, Dusetti, Nelson, Iovanna, Juan, Carrier, Alice
Publicado 2023

Diet-induced loss of adipose hexokinase 2 correlates with hyperglycemia

por Shimobayashi, Mitsugu, Thomas, Amandine, Shetty, Sunil, Frei, Irina C, Wölnerhanssen, Bettina K, Weissenberger, Diana, Vandekeere, Anke, Planque, Mélanie, Dietz, Nikolaus, Ritz, Danilo, Meyer-Gerspach, Anne Christin, Maier, Timm, Hay, Nissim, Peterli, Ralph, Fendt, Sarah-Maria, Rohner, Nicolas, Hall, Michael N
Publicado 2023

Effects of the Novel PFKFB3 Inhibitor KAN0438757 on Colorectal Cancer Cells and Its Systemic Toxicity Evaluation In Vivo

por De Oliveira, Tiago, Goldhardt, Tina, Edelmann, Marcus, Rogge, Torben, Rauch, Karsten, Kyuchukov, Nikola Dobrinov, Menck, Kerstin, Bleckmann, Annalen, Kalucka, Joanna, Khan, Shawez, Gaedcke, Jochen, Haubrock, Martin, Beissbarth, Tim, Bohnenberger, Hanibal, Planque, Mélanie, Fendt, Sarah-Maria, Ackermann, Lutz, Ghadimi, Michael, Conradi, Lena-Christin
Publicado 2021

Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis

por Dorsch, Madeleine, Kowalczyk, Manuela, Planque, Mélanie, Heilmann, Geronimo, Urban, Sebastian, Dujardin, Philip, Forster, Jan, Ueffing, Kristina, Nothdurft, Silke, Oeck, Sebastian, Paul, Annika, Liffers, Sven T., Kaschani, Farnusch, Kaiser, Markus, Schramm, Alexander, Siveke, Jens T., Winslow, Monte M., Fendt, Sarah-Maria, Nalbant, Perihan, Grüner, Barbara M.
Publicado 2021

Translatome analysis reveals altered serine and glycine metabolism in T-cell acute lymphoblastic leukemia cells

por Kampen, Kim R., Fancello, Laura, Girardi, Tiziana, Rinaldi, Gianmarco, Planque, Mélanie, Sulima, Sergey O., Loayza-Puch, Fabricio, Verbelen, Benno, Vereecke, Stijn, Verbeeck, Jelle, Op de Beeck, Joyce, Royaert, Jonathan, Vermeersch, Pieter, Cassiman, David, Cools, Jan, Agami, Reuven, Fiers, Mark, Fendt, Sarah-Maria, De Keersmaecker, Kim
Publicado 2019

Molecular differences of angiogenic versus vessel co-opting colorectal cancer liver metastases at single-cell resolution

por Fleischer, Johannes Robert, Schmitt, Alexandra Maria, Haas, Gwendolyn, Xu, Xingbo, Zeisberg, Elisabeth Maria, Bohnenberger, Hanibal, Küffer, Stefan, Teuwen, Laure-Anne, Karras, Philipp Johannes, Beißbarth, Tim, Bleckmann, Annalen, Planque, Mélanie, Fendt, Sarah-Maria, Vermeulen, Peter, Ghadimi, Michael, Kalucka, Joanna, De Oliveira, Tiago, Conradi, Lena-Christin
Publicado 2023

Endothelial Lactate Controls Muscle Regeneration from Ischemia by Inducing M2-like Macrophage Polarization

por Zhang, Jing, Muri, Jonathan, Fitzgerald, Gillian, Gorski, Tatiane, Gianni-Barrera, Roberto, Masschelein, Evi, D’Hulst, Gommaar, Gilardoni, Paola, Turiel, Guillermo, Fan, Zheng, Wang, TongTong, Planque, Mélanie, Carmeliet, Peter, Pellerin, Luc, Wolfrum, Christian, Fendt, Sarah-Maria, Banfi, Andrea, Stockmann, Christian, Soro-Arnáiz, Inés, Kopf, Manfred, De Bock, Katrien
Publicado 2020

Age-induced methylmalonic acid accumulation promotes tumor progression

por Gomes, Ana P., Ilter, Didem, Low, Vivien, Endress, Jennifer E., Fernández-García, Juan, Rosenzweig, Adam, Schild, Tanya, Broekaert, Dorien, Ahmed, Adnan, Planque, Melanie, Elia, Ilaria, Han, Julie, Kinzig, Charles, Mullarky, Edouard, Mutvei, Anders P., Asara, John, de Cabo, Rafael, Cantley, Lewis C., Dephoure, Noah, Fendt, Sarah-Maria, Blenis, John
Publicado 2020

SOX9-induced Generation of Functional Astrocytes Supporting Neuronal Maturation in an All-human System

por Neyrinck, Katrien, Van Den Daele, Johanna, Vervliet, Tim, De Smedt, Jonathan, Wierda, Keimpe, Nijs, Melissa, Vanbokhoven, Tom, D’hondt, Astrid, Planque, Mélanie, Fendt, Sarah-Maria, Shih, Pei-Yu, Seibt, Frederik, Almenar, Juan Pita, Kreir, Mohamed, Kumar, Devesh, Broccoli, Vania, Bultynck, Geert, Ebneth, Andreas, Cabrera-Socorro, Alfredo, Verfaillie, Catherine
Publicado 2021

Pharmacological induction of membrane lipid poly-unsaturation sensitizes melanoma to ROS inducers and overcomes acquired resistance to targeted therapy

por Talebi, Ali, de Laat, Vincent, Spotbeen, Xander, Dehairs, Jonas, Rambow, Florian, Rogiers, Aljosja, Vanderhoydonc, Frank, Rizotto, Lara, Planque, Mélanie, Doglioni, Ginevra, Motamedi, Sahar, Nittner, David, Roskams, Tania, Agostinis, Patrizia, Bechter, Oliver, Boecxstaens, Veerle, Garmyn, Marjan, O’Farrell, Marie, Wagman, Alan, Kemble, George, Leucci, Eleonora, Fendt, Sarah-Maria, Marine, Jean-Christophe, Swinnen, Johannes V.
Publicado 2023

2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer

por Blomme, Arnaud, Ford, Catriona A., Mui, Ernest, Patel, Rachana, Ntala, Chara, Jamieson, Lauren E., Planque, Mélanie, McGregor, Grace H., Peixoto, Paul, Hervouet, Eric, Nixon, Colin, Salji, Mark, Gaughan, Luke, Markert, Elke, Repiscak, Peter, Sumpton, David, Blanco, Giovanny Rodriguez, Lilla, Sergio, Kamphorst, Jurre J., Graham, Duncan, Faulds, Karen, MacKay, Gillian M., Fendt, Sarah-Maria, Zanivan, Sara, Leung, Hing Y.
Publicado 2020

Serine metabolism remodeling after platinum-based chemotherapy identifies vulnerabilities in a subgroup of resistant ovarian cancers

por Van Nyen, Tom, Planque, Mélanie, van Wagensveld, Lilian, Duarte, Joao A. G., Zaal, Esther A., Talebi, Ali, Rossi, Matteo, Körner, Pierre-René, Rizzotto, Lara, Moens, Stijn, De Wispelaere, Wout, Baiden-Amissah, Regina E. M., Sonke, Gabe S., Horlings, Hugo M., Eelen, Guy, Berardi, Emanuele, Swinnen, Johannes V., Berkers, Celia R., Carmeliet, Peter, Lambrechts, Diether, Davidson, Ben, Agami, Reuven, Fendt, Sarah-Maria, Annibali, Daniela, Amant, Frédéric
Publicado 2022

A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation resulting in pro-metastatic NF-κB signaling

por Altea-Manzano, Patricia, Doglioni, Ginevra, Liu, Yawen, Cuadros, Alejandro M., Nolan, Emma, Fernández-García, Juan, Wu, Qi, Planque, Mélanie, Laue, Kathrin Julia, Cidre-Aranaz, Florencia, Liu, Xiao-Zheng, Marin-Bejar, Oskar, Van Elsen, Joke, Vermeire, Ines, Broekaert, Dorien, Demeyer, Sofie, Spotbeen, Xander, Idkowiak, Jakub, Montagne, Aurelie, Demicco, Margherita, Alkan, H Furkan, Rabas, Nick, Riera-Domingo, Carla, Richard, François, Geukens, Tatjana, De Schepper, Maxim, Leduc, Sophia, Hatse, Sigrid, Lambrechts, Yentl, Kay, Emily Jane, Lilla, Sergio, Alekseenko, Alisa, Geldhof, Vincent, Boeckx, Bram, de la Calle Arregui, Celia, Floris, Giuseppe, Swinnen, Johannes V., Marine, Jean-Christophe, Lambrechts, Diether, Pelechano, Vicent, Mazzone, Massimiliano, Zanivan, Sara, Cools, Jan, Wildiers, Hans, Baud, Véronique, Grünewald, Thomas G.P., Ben-David, Uri, Desmedt, Christine, Malanchi, Ilaria, Fendt, Sarah-Maria
Publicado 2023