Small-Molecule Lysophosphatidic Acid Receptor 5 (LPAR5) Antagonists: Versatile Pharmacological Tools to Regulate Inflammatory Signaling in BV-2 Microglia Cells

por Plastira, Ioanna, Joshi, Lisha, Bernhart, Eva, Schoene, Jens, Specker, Edgar, Nazare, Marc, Sattler, Wolfgang
Publicado 2019

Inhibition of Autotaxin and Lysophosphatidic Acid Receptor 5 Attenuates Neuroinflammation in LPS-Activated BV-2 Microglia and a Mouse Endotoxemia Model

por Joshi, Lisha, Plastira, Ioanna, Bernhart, Eva, Reicher, Helga, Triebl, Alexander, Köfeler, Harald C., Sattler, Wolfgang
Publicado 2021

MAPK signaling determines lysophosphatidic acid (LPA)-induced inflammation in microglia

por Plastira, Ioanna, Bernhart, Eva, Joshi, Lisha, Koyani, Chintan N., Strohmaier, Heimo, Reicher, Helga, Malle, Ernst, Sattler, Wolfgang
Publicado 2020

Lysophosphatidic Acid Receptor 5 (LPA(5)) Knockout Ameliorates the Neuroinflammatory Response In Vivo and Modifies the Inflammatory and Metabolic Landscape of Primary Microglia In...

por Joshi, Lisha, Plastira, Ioanna, Bernhart, Eva, Reicher, Helga, Koshenov, Zhanat, Graier, Wolfgang F., Vujic, Nemanja, Kratky, Dagmar, Rivera, Richard, Chun, Jerold, Sattler, Wolfgang
Publicado 2022

Interference with distinct steps of sphingolipid synthesis and signaling attenuates proliferation of U87MG glioma cells

por Bernhart, Eva, Damm, Sabine, Wintersperger, Andrea, Nusshold, Christoph, Brunner, Anna Martina, Plastira, Ioanna, Rechberger, Gerald, Reicher, Helga, Wadsack, Christian, Zimmer, Andreas, Malle, Ernst, Sattler, Wolfgang
Publicado 2015

Lysophosphatidic Acid Induces Aerobic Glycolysis, Lipogenesis, and Increased Amino Acid Uptake in BV-2 Microglia

por Joshi, Lisha, Plastira, Ioanna, Bernhart, Eva, Reicher, Helga, Koyani, Chintan N., Madl, Tobias, Madreiter-Sokolowski, Corina, Koshenov, Zhanat, Graier, Wolfgang F., Hallström, Seth, Sattler, Wolfgang
Publicado 2021

1-Oleyl-lysophosphatidic acid (LPA) promotes polarization of BV-2 and primary murine microglia towards an M1-like phenotype

por Plastira, Ioanna, Bernhart, Eva, Goeritzer, Madeleine, Reicher, Helga, Kumble, Vishwanath Bhat, Kogelnik, Nora, Wintersperger, Andrea, Hammer, Astrid, Schlager, Stefanie, Jandl, Katharina, Heinemann, Akos, Kratky, Dagmar, Malle, Ernst, Sattler, Wolfgang
Publicado 2016

Saxagliptin but Not Sitagliptin Inhibits CaMKII and PKC via DPP9 Inhibition in Cardiomyocytes

por Koyani, Chintan N., Trummer, Christopher, Shrestha, Niroj, Scheruebel, Susanne, Bourgeois, Benjamin, Plastira, Ioanna, Kickmaier, Sandra, Sourij, Harald, Rainer, Peter P., Madl, Tobias, Sattler, Wolfgang, Pelzmann, Brigitte, Malle, Ernst, von Lewinski, Dirk
Publicado 2018

Myeloperoxidase and Septic Conditions Disrupt Sphingolipid Homeostasis in Murine Brain Capillaries In Vivo and Immortalized Human Brain Endothelial Cells In Vitro

por Goeritzer, Madeleine, Bernhart, Eva, Plastira, Ioanna, Reicher, Helga, Leopold, Christina, Eichmann, Thomas O., Rechberger, Gerald, Madreiter-Sokolowski, Corina T., Prasch, Jürgen, Eller, Philipp, Graier, Wolfgang F., Kratky, Dagmar, Malle, Ernst, Sattler, Wolfgang
Publicado 2020

2-Chlorohexadecanoic acid induces ER stress and mitochondrial dysfunction in brain microvascular endothelial cells

por Bernhart, Eva, Kogelnik, Nora, Prasch, Jürgen, Gottschalk, Benjamin, Goeritzer, Madeleine, Depaoli, Maria Rosa, Reicher, Helga, Nusshold, Christoph, Plastira, Ioanna, Hammer, Astrid, Fauler, Günter, Malli, Roland, Graier, Wolfgang F., Malle, Ernst, Sattler, Wolfgang
Publicado 2018

Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration

por Ryu, Jae Kyu, Rafalski, Victoria A., Meyer-Franke, Anke, Adams, Ryan A., Poda, Suresh B., Coronado, Pamela E. Rios, Pedersen, Lars Østergaard, Menon, Veena, Baeten, Kim M., Sikorski, Shoana L., Bedard, Catherine, Hanspers, Kristina, Bardehle, Sophia, Mendiola, Andrew S., Davalos, Dimitrios, Machado, Michael R., Chan, Justin P., Plastira, Ioanna, Petersen, Mark A., Pfaff, Samuel J., Ang, Kenny K., Hallenbeck, Kenneth K., Syme, Catriona, Hakozaki, Hiroyuki, Ellisman, Mark H., Swanson, Raymond A., Zamvil, Scott S., Arkin, Michelle R., Zorn, Stevin H., Pico, Alexander R., Mucke, Lennart, Freedman, Stephen B., Stavenhagen, Jeffrey B., Nelson, Robert B., Akassoglou, Katerina
Publicado 2018