Plasmodium falciparum Resistance to a Lead Benzoxaborole Due to Blocked Compound Activation and Altered Ubiquitination or Sumoylation

por Sindhe, Kirthana M. V., Wu, Wesley, Legac, Jenny, Zhang, Yong-Kang, Easom, Eric E., Cooper, Roland A., Plattner, Jacob J., Freund, Yvonne R., DeRisi, Joseph L., Rosenthal, Philip J.
Publicado 2020

Benzoxaborole Antimalarial Agents. Part 4. Discovery of Potent 6-(2-(Alkoxycarbonyl)pyrazinyl-5-oxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles

por Zhang, Yong-Kang, Plattner, Jacob J., Easom, Eric E., Jacobs, Robert T., Guo, Denghui, Sanders, Virginia, Freund, Yvonne R., Campo, Brice, Rosenthal, Philip J., Bu, Wei, Gamo, Francisco-Javier, Sanz, Laura M., Ge, Min, Li, Liang, Ding, Jie, Yang, Yin
Publicado 2015

Identification of a 4-fluorobenzyl l-valinate amide benzoxaborole (AN11736) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT)

por Akama, Tsutomu, Zhang, Yong-Kang, Freund, Yvonne R., Berry, Pamela, Lee, Joanne, Easom, Eric E., Jacobs, Robert T., Plattner, Jacob J., Witty, Michael J., Peter, Rosemary, Rowan, Tim G., Gillingwater, Kirsten, Brun, Reto, Nare, Bakela, Mercer, Luke, Xu, Musheng, Wang, Jiangong, Liang, Hao
Publicado 2018

Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis

por Lunde, Christopher S., Stebbins, Erin E., Jumani, Rajiv S., Hasan, Md Mahmudul, Miller, Peter, Barlow, John, Freund, Yvonne R., Berry, Pamela, Stefanakis, Rianna, Gut, Jiri, Rosenthal, Philip J., Love, Melissa S., McNamara, Case W., Easom, Eric, Plattner, Jacob J., Jacobs, Robert T., Huston, Christopher D.
Publicado 2019

In vivo efficacy of the boron-pleuromutilin AN11251 against Wolbachia of the rodent filarial nematode Litomosoides sigmodontis

por Ehrens, Alexandra, Lunde, Christopher S., Jacobs, Robert T., Struever, Dominique, Koschel, Marianne, Frohberger, Stefan J., Lenz, Franziska, Fendler, Martina, Turner, Joseph D., Ward, Stephen A., Taylor, Mark J., Freund, Yvonne R., Stefanakis, Rianna, Easom, Eric, Li, Xianfeng, Plattner, Jacob J., Hoerauf, Achim, Hübner, Marc P.
Publicado 2020

Macrofilaricidal Benzimidazole–Benzoxaborole Hybrids as an Approach to the Treatment of River Blindness: Part 2. Ketone Linked Analogs

por Carter, David S., Jacobs, Robert T., Freund, Yvonne R., Berry, Pamela W., Akama, Tsutomu, Easom, Eric E., Lunde, Christopher S., Rock, Fernando, Stefanakis, Rianna, McKerrow, James, Fischer, Chelsea, Bulman, Christina A., Lim, Kee Chong, Suzuki, Brian M., Tricoche, Nancy, Sakanari, Judy A., Lustigman, Sara, Plattner, Jacob J.
Publicado 2019

SCYX-7158, an Orally-Active Benzoxaborole for the Treatment of Stage 2 Human African Trypanosomiasis

por Jacobs, Robert T., Nare, Bakela, Wring, Stephen A., Orr, Matthew D., Chen, Daitao, Sligar, Jessica M., Jenks, Matthew X., Noe, Robert A., Bowling, Tana S., Mercer, Luke T., Rewerts, Cindy, Gaukel, Eric, Owens, Jennifer, Parham, Robin, Randolph, Ryan, Beaudet, Beth, Bacchi, Cyrus J., Yarlett, Nigel, Plattner, Jacob J., Freund, Yvonne, Ding, Charles, Akama, Tsutomu, Zhang, Y.-K., Brun, Reto, Kaiser, Marcel, Scandale, Ivan, Don, Robert
Publicado 2011

Macrofilaricidal Benzimidazole–Benzoxaborole Hybrids as an Approach to the Treatment of River Blindness: Part 1. Amide Linked Analogs

por Akama, Tsutomu, Freund, Yvonne R., Berry, Pamela W., Carter, David S., Easom, Eric E., Jarnagin, Kurt, Lunde, Christopher S., Plattner, Jacob J., Rock, Fernando, Stefanakis, Rianna, Fischer, Chelsea, Bulman, Christina A., Lim, Kee Chong, Suzuki, Brian M., Tricoche, Nancy, Mansour, Abdelmoneim, DiCosty, Utami, McCall, Scott, Carson, Ben, McCall, John W., McKerrow, James, Hübner, Marc P., Specht, Sabine, Hoerauf, Achim, Lustigman, Sara, Sakanari, Judy A., Jacobs, Robert T.
Publicado 2019

Boron-Pleuromutilins as Anti-Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis

por Jacobs, Robert T., Lunde, Christopher S., Freund, Yvonne R., Hernandez, Vincent, Li, Xianfeng, Xia, Yi, Carter, David S., Berry, Pamela W., Halladay, Jason, Rock, Fernando, Stefanakis, Rianna, Easom, Eric, Plattner, Jacob J., Ford, Louise, Johnston, Kelly L., Cook, Darren A. N., Clare, Rachel, Cassidy, Andrew, Myhill, Laura, Tyrer, Hayley, Gamble, Joanne, Guimaraes, Ana F., Steven, Andrew, Lenz, Franziska, Ehrens, Alexandra, Frohberger, Stefan J., Koschel, Marianne, Hoerauf, Achim, Hübner, Marc P., McNamara, Case W., Bakowski, Malina A., Turner, Joseph D., Taylor, Mark J., Ward, Stephen A.
Publicado 2019

Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase

por Palencia, Andrés, Li, Xianfeng, Bu, Wei, Choi, Wai, Ding, Charles Z., Easom, Eric E., Feng, Lisa, Hernandez, Vincent, Houston, Paul, Liu, Liang, Meewan, Maliwan, Mohan, Manisha, Rock, Fernando L., Sexton, Holly, Zhang, Suoming, Zhou, Yasheen, Wan, Baojie, Wang, Yuehong, Franzblau, Scott G., Woolhiser, Lisa, Gruppo, Veronica, Lenaerts, Anne J., O'Malley, Theresa, Parish, Tanya, Cooper, Christopher B., Waters, M. Gerard, Ma, Zhenkun, Ioerger, Thomas R., Sacchettini, James C., Rullas, Joaquín, Angulo-Barturen, Iñigo, Pérez-Herrán, Esther, Mendoza, Alfonso, Barros, David, Cusack, Stephen, Plattner, Jacob J., Alley, M. R. K.
Publicado 2016