Cyclic di-GMP mediates a histidine kinase/phosphatase switch by noncovalent domain cross-linking

por Dubey, Badri N., Lori, Christian, Ozaki, Shogo, Fucile, Geoffrey, Plaza-Menacho, Ivan, Jenal, Urs, Schirmer, Tilman
Publicado 2016

Structural and dynamic determinants for highly selective RET kinase inhibition reveal cryptic druggability

por Shehata, Moustafa A., Contreras, Julia, Martín-Hurtado, Ana, Froux, Aurane, Mohamed, Hossam Taha, El-Sherif, Ahmed A., Plaza-Menacho, Iván
Publicado 2022

Hybrid histidine kinase activation by cyclic di-GMP–mediated domain liberation

por Dubey, Badri N., Agustoni, Elia, Böhm, Raphael, Kaczmarczyk, Andreas, Mangia, Francesca, von Arx, Christoph, Jenal, Urs, Hiller, Sebastian, Plaza-Menacho, Iván, Schirmer, Tilman
Publicado 2020

Oncogenic RET Kinase Domain Mutations Perturb the Autophosphorylation Trajectory by Enhancing Substrate Presentation In trans

por Plaza-Menacho, Iván, Barnouin, Karin, Goodman, Kerry, Martínez-Torres, Rubén J., Borg, Annabel, Murray-Rust, Judith, Mouilleron, Stephane, Knowles, Phillip, McDonald, Neil Q.
Publicado 2014

RET Functions as a Dual-Specificity Kinase that Requires Allosteric Inputs from Juxtamembrane Elements

por Plaza-Menacho, Iván, Barnouin, Karin, Barry, Rachael, Borg, Annabel, Orme, Mariam, Chauhan, Rakhee, Mouilleron, Stephane, Martínez-Torres, Rubén J., Meier, Pascal, McDonald, Neil Q.
Publicado 2016

An allosteric switch between the activation loop and a c-terminal palindromic phospho-motif controls c-Src function

por Cuesta-Hernández, Hipólito Nicolás, Contreras, Julia, Soriano-Maldonado, Pablo, Sánchez-Wandelmer, Jana, Yeung, Wayland, Martín-Hurtado, Ana, Muñoz, Inés G., Kannan, Natarajan, Llimargas, Marta, Muñoz, Javier, Plaza-Menacho, Iván
Publicado 2023