MEK inhibitors as novel host-targeted antivirals with a dual-benefit mode of action against hyperinflammatory respiratory viral diseases

por Ludwig, Stephan, Pleschka, Stephan, Planz, Oliver
Publicado 2023

Replication and Adaptive Mutations of Low Pathogenic Avian Influenza Viruses in Tracheal Organ Cultures of Different Avian Species

por Petersen, Henning, Matrosovich, Mikhail, Pleschka, Stephan, Rautenschlein, Silke
Publicado 2012

Anti-viral approaches against influenza viruses

por Pleschka, Stephan, Ludwig, Stephan, Wolff, Thorsten, Planz, Oliver
Publicado 2006

Anti-viral properties and mode of action of standardized Echinacea purpurea extract against highly pathogenic avian Influenza virus (H5N1, H7N7) and swine-origin H1N1 (S-OIV)

por Pleschka, Stephan, Stein, Michael, Schoop, Roland, Hudson, James B
Publicado 2009

Effect of an Echinacea-Based Hot Drink Versus Oseltamivir in Influenza Treatment: A Randomized, Double-Blind, Double-Dummy, Multicenter, Noninferiority Clinical Trial

por Rauš, Karel, Pleschka, Stephan, Klein, Peter, Schoop, Roland, Fisher, Peter
Publicado 2015

Zoonotic Potential of Influenza A Viruses: A Comprehensive Overview

por Mostafa, Ahmed, Abdelwhab, Elsayed M., Mettenleiter, Thomas C., Pleschka, Stephan
Publicado 2018

Combinatory Treatment with Oseltamivir and Itraconazole Targeting Both Virus and Host Factors in Influenza A Virus Infection

por Schloer, Sebastian, Goretzko, Jonas, Pleschka, Stephan, Ludwig, Stephan, Rescher, Ursula
Publicado 2020

A Novel Antiviral Strategy against MERS-CoV and HCoV-229E Using Binase to Target Viral Genome Replication

por Müller, Christin, Ulyanova, Vera, Ilinskaya, Olga, Pleschka, Stephan, Shah Mahmud, Raihan
Publicado 2016

Improved in vitro Efficacy of Baloxavir Marboxil Against Influenza A Virus Infection by Combination Treatment With the MEK Inhibitor ATR-002

por Hamza, Hazem, Shehata, Mahmoud M., Mostafa, Ahmed, Pleschka, Stephan, Planz, Oliver
Publicado 2021

Efficient Generation of Recombinant Influenza A Viruses Employing a New Approach to Overcome the Genetic Instability of HA Segments

por Mostafa, Ahmed, Kanrai, Pumaree, Petersen, Henning, Ibrahim, Sherif, Rautenschlein, Silke, Pleschka, Stephan
Publicado 2015

Higher polymerase activity of a human influenza virus enhances activation of the hemagglutinin-induced Raf/MEK/ERK signal cascade

por Marjuki, Henju, Yen, Hui-Ling, Franks, John, Webster, Robert G, Pleschka, Stephan, Hoffmann, Erich
Publicado 2007

Inhibitory activity of a standardized elderberry liquid extract against clinically-relevant human respiratory bacterial pathogens and influenza A and B viruses

por Krawitz, Christian, Mraheil, Mobarak Abu, Stein, Michael, Imirzalioglu, Can, Domann, Eugen, Pleschka, Stephan, Hain, Torsten
Publicado 2011

Ribonuclease from Bacillus Acts as an Antiviral Agent against Negative- and Positive-Sense Single Stranded Human Respiratory RNA Viruses

por Shah Mahmud, Raihan, Müller, Christin, Romanova, Yulia, Mostafa, Ahmed, Ulyanova, Vera, Pleschka, Stephan, Ilinskaya, Olga
Publicado 2017

Phosphorylation of Influenza A Virus Matrix Protein 1 at Threonine 108 Controls Its Multimerization State and Functional Association with the STRIPAK Complex

por Liu, Lu, Weber, Axel, Linne, Uwe, Shehata, Mahmoud, Pleschka, Stephan, Kracht, Michael, Schmitz, M. Lienhard
Publicado 2023

Phosphorylation of the PA subunit of influenza polymerase at Y393 prevents binding of the 5′-termini of RNA and polymerase function

por Liu, Lu, Madhugiri, Ramakanth, Saul, Vera Vivian, Bacher, Susanne, Kracht, Michael, Pleschka, Stephan, Schmitz, M. Lienhard
Publicado 2023

In Silico Prediction and Experimental Confirmation of HA Residues Conferring Enhanced Human Receptor Specificity of H5N1 Influenza A Viruses

por Schmier, Sonja, Mostafa, Ahmed, Haarmann, Thomas, Bannert, Norbert, Ziebuhr, John, Veljkovic, Veljko, Dietrich, Ursula, Pleschka, Stephan
Publicado 2015

Anti-Influenza Activity of the Ribonuclease Binase: Cellular Targets Detected by Quantitative Proteomics

por Ulyanova, Vera, Shah Mahmud, Raihan, Laikov, Alexander, Dudkina, Elena, Markelova, Maria, Mostafa, Ahmed, Pleschka, Stephan, Ilinskaya, Olga
Publicado 2020

Broad Antiviral Effects of Echinacea purpurea against SARS-CoV-2 Variants of Concern and Potential Mechanism of Action

por Vimalanathan, Selvarani, Shehata, Mahmoud, Sadasivam, Kannan, Delbue, Serena, Dolci, Maria, Pariani, Elena, D’Alessandro, Sarah, Pleschka, Stephan
Publicado 2022

Targeting intracellular signaling as an antiviral strategy: aerosolized LASAG for the treatment of influenza in hospitalized patients

por Scheuch, Gerhard, Canisius, Sebastian, Nocker, Karlheinz, Hofmann, Thomas, Naumann, Rolf, Pleschka, Stephan, Ludwig, Stephan, Welte, Tobias, Planz, Oliver
Publicado 2018

Bacterial ribonuclease binase exerts an intra-cellular anti-viral mode of action targeting viral RNAs in influenza a virus-infected MDCK-II cells

por Shah Mahmud, Raihan, Mostafa, Ahmed, Müller, Christin, Kanrai, Pumaree, Ulyanova, Vera, Sokurenko, Yulia, Dzieciolowski, Julia, Kuznetsova, Irina, Ilinskaya, Olga, Pleschka, Stephan
Publicado 2018