Safety, tolerability, pharmacodynamics and pharmacokinetics following once‐daily doses of BI 187004, an inhibitor of 11 beta‐hydroxysteroid dehydrogenase‐1, over 28 days in patient...

por Bianzano, Susanna, Nordaby, Matias, Plum‐Mörschel, Leona, Peil, Barbara, Heise, Tim
Publicado 2022

Validation of a Novel Method for Determining the Renal Threshold for Glucose Excretion in Untreated and Canagliflozin-treated Subjects With Type 2 Diabetes Mellitus

por Polidori, David, Sha, Sue, Ghosh, Atalanta, Plum-Mörschel, Leona, Heise, Tim, Rothenberg, Paul
Publicado 2013

The Effect of Food Intake on the Pharmacokinetics of Oral Basal Insulin: A Randomised Crossover Trial in Healthy Male Subjects

por Halberg, Inge B., Lyby, Karsten, Wassermann, Karsten, Heise, Tim, Plum-Mörschel, Leona, Zijlstra, Eric
Publicado 2019

Clinical Characteristics of a Non-Alcoholic Fatty Liver Disease Population Across the Fibrosis Spectrum Measured by Magnetic Resonance Elastography: Analysis of Screening Data

por Andersen, Grit, Plum-Mörschel, Leona, Hockings, Paul D., Morsing, Anni, Palle, Mads S., Svolgaard, Olivia, Flint, Anne
Publicado 2020

Pharmacokinetic and pharmacodynamic equivalence of Biocon's biosimilar Insulin‐R with the US‐licensed Humulin® R formulation in healthy subjects: Results from the RHINE‐1 (Recombin...

por Plum‐Mörschel, Leona, Singh, Gursharan, Murugesan, Sundara Moorthi Nainar, Marwah, Ashwani, Panda, Jayanti, Loganathan, Subramanian, Athalye, Sandeep N.
Publicado 2022

Hypoglycemia Risk Related to Double Dose Is Markedly Reduced with Basal Insulin Peglispro Versus Insulin Glargine in Patients with Type 2 Diabetes Mellitus in a Randomized Trial: I...

por Harris, Cynthia, Forst, Thomas, Heise, Tim, Plum-Mörschel, Leona, Watkins, Elaine, Zhang, Qianyi, Fan, Ludi, Garhyan, Parag, Porksen, Niels
Publicado 2017

Dasiglucagon—A Next-Generation Glucagon Analog for Rapid and Effective Treatment of Severe Hypoglycemia: Results of Phase 3 Randomized Double-Blind Clinical Trial

por Pieber, Thomas R., Aronson, Ronnie, Hövelmann, Ulrike, Willard, Julie, Plum-Mörschel, Leona, Knudsen, Kim M., Bandak, Benedikte, Tehranchi, Ramin
Publicado 2021

Ultra rapid lispro (URLi) shows accelerated pharmacokinetics and greater reduction in postprandial glucose versus Humalog® in patients with type 1 diabetes mellitus in a randomized...

por Kazda, Christof, Leohr, Jennifer, Liu, Rong, Reddy, Shobha, Dellva, Mary Anne, Loh, Mei Teng, Hardy, Thomas, Plum‐Mörschel, Leona
Publicado 2021

Randomised clinical trial: semaglutide versus placebo reduced liver steatosis but not liver stiffness in subjects with non‐alcoholic fatty liver disease assessed by magnetic resona...

por Flint, Anne, Andersen, Grit, Hockings, Paul, Johansson, Lars, Morsing, Anni, Sundby Palle, Mads, Vogl, Thomas, Loomba, Rohit, Plum‐Mörschel, Leona
Publicado 2021

Pharmacokinetic and Pharmacodynamic Characteristics of Insulin Icodec After Subcutaneous Administration in the Thigh, Abdomen or Upper Arm in Individuals with Type 2 Diabetes Melli...

por Plum-Mörschel, Leona, Andersen, Lizette Ravn, Hansen, Solvejg, Hövelmann, Ulrike, Krawietz, Patricia, Kristensen, Niels Rode, Lehrskov, Lars Lang, Haahr, Hanne
Publicado 2023

Injecting without pressing a button: An exploratory study of a shield‐triggered injection mechanism

por Zijlstra, Eric, Coester, Hans‐Veit, Heise, Tim, Plum‐Mörschel, Leona, Rasmussen, Ole, Rikte, Tord, Pedersen, Line Kynemund, Qvist, Marianne, Sparre, Thomas
Publicado 2018

Glucagon Administration by Nasal and Intramuscular Routes in Adults With Type 1 Diabetes During Insulin-Induced Hypoglycaemia: A Randomised, Open-Label, Crossover Study

por Suico, Jeffrey G., Hövelmann, Ulrike, Zhang, Shuyu, Shen, Tong, Bergman, Brandon, Sherr, Jennifer, Zijlstra, Eric, Frier, Brian M., Plum-Mörschel, Leona
Publicado 2020

Pharmacokinetics and Glucodynamics of Ultra Rapid Lispro (URLi) versus Humalog(®) (Lispro) in Younger Adults and Elderly Patients with Type 1 Diabetes Mellitus: A Randomised Contro...

por Linnebjerg, Helle, Zhang, Qianyi, LaBell, Elizabeth, Dellva, Mary Anne, Coutant, David E., Hövelmann, Ulrike, Plum-Mörschel, Leona, Herbrand, Theresa, Leohr, Jennifer
Publicado 2020

Blunted Refeeding Response and Increased Locomotor Activity in Mice Lacking FoxO1 in Synapsin-Cre–Expressing Neurons

por Ren, Hongxia, Plum-Morschel, Leona, Gutierrez-Juarez, Roger, Lu, Taylor Y., Kim-Muller, Ja Young, Heinrich, Garrett, Wardlaw, Sharon L., Silver, Rae, Accili, Domenico
Publicado 2013

Pharmacokinetic and pharmacodynamic equivalence of Biocon's biosimilar Insulin 70/30 with US‐licensed HUMULIN® 70/30 formulation in healthy subjects: Results from the RHINE‐3 (Reco...

por Plum‐Mörschel, Leona, Klein, Oliver, Singh, Gursharan, Murugesan, Sundara Moorthi Nainar, Marwah, Ashwani, Sharma, Nirant, Panda, Jayanti, Loganathan, Subramanian, Lakshmi, Gopu Chandrasekharan, Athalye, Sandeep N.
Publicado 2022

Endothelial‐protective effects of a G‐protein‐biased sphingosine‐1 phosphate receptor‐1 agonist, SAR247799, in type‐2 diabetes rats and a randomized placebo‐controlled patient tria...

por Bergougnan, Luc, Andersen, Grit, Plum‐Mörschel, Leona, Evaristi, Maria Francesca, Poirier, Bruno, Tardat, Agnes, Ermer, Marcel, Herbrand, Theresa, Arrubla, Jorge, Coester, Hans Veit, Sansone, Roberto, Heiss, Christian, Vitse, Olivier, Hurbin, Fabrice, Boiron, Rania, Benain, Xavier, Radzik, David, Janiak, Philip, Muslin, Anthony J., Hovsepian, Lionel, Kirkesseli, Stephane, Deutsch, Paul, Parkar, Ashfaq A.
Publicado 2020