Drug Targeting and Nanomedicine: Lessons Learned from Liver Targeting and Opportunities for Drug Innovation

por Salvati, Anna, Poelstra, Klaas
Publicado 2022

Anticancer Effects of 15d-Prostaglandin-J(2) in Wild-Type and Doxorubicin-Resistant Ovarian Cancer Cells: Novel Actions on SIRT1 and HDAC

por de Jong, Edwin, Winkel, Peter, Poelstra, Klaas, Prakash, Jai
Publicado 2011

Targeted Recombinant Fusion Proteins of IFNγ and Mimetic IFNγ with PDGFβR Bicyclic Peptide Inhibits Liver Fibrogenesis In Vivo

por Bansal, Ruchi, Prakash, Jai, De Ruiter, Marieke, Poelstra, Klaas
Publicado 2014

Targeted Therapies in Liver Fibrosis: Combining the Best Parts of Platelet-Derived Growth Factor BB and Interferon Gamma

por van Dijk, Fransien, Olinga, Peter, Poelstra, Klaas, Beljaars, Leonie
Publicado 2015

Increased Liver Uptake and Reduced Hepatic Stellate Cell Activation with a Cell-Specific Conjugate of the Rho-kinase Inhibitor Y27632

por van Beuge, Marike Marjolijn, Prakash, Jai, Lacombe, Marie, Post, Eduard, Reker-Smit, Catharina, Beljaars, Leonie, Poelstra, Klaas
Publicado 2011

Enhanced Effectivity of an ALK5-Inhibitor after Cell-Specific Delivery to Hepatic Stellate Cells in Mice with Liver Injury

por van Beuge, Marike Marjolijn, Prakash, Jai, Lacombe, Marie, Post, Eduard, Reker-Smit, Catharina, Beljaars, Leonie, Poelstra, Klaas
Publicado 2013

Hepatic Localization of Macrophage Phenotypes during Fibrogenesis and Resolution of Fibrosis in Mice and Humans

por Beljaars, Leonie, Schippers, Marlies, Reker-Smit, Catharina, Martinez, Fernando O., Helming, Laura, Poelstra, Klaas, Melgert, Barbro N.
Publicado 2014

Precision-cut kidney slices (PCKS) to study development of renal fibrosis and efficacy of drug targeting ex vivo

por Poosti, Fariba, Pham, Bao Tung, Oosterhuis, Dorenda, Poelstra, Klaas, van Goor, Harry, Olinga, Peter, Hillebrands, Jan-Luuk
Publicado 2015

Design of a Gene Panel to Expose the Versatile Role of Hepatic Stellate Cells in Human Liver Fibrosis

por van Dijk, Fransien, Hazelhoff, Christa M., Post, Eduard, Prins, Gerian G. H., Rombouts, Krista, Poelstra, Klaas, Olinga, Peter, Beljaars, Leonie
Publicado 2020

RGD-avidin–biotin pretargeting to α(v)β(3) integrin enhances the proapoptotic activity of TNFα related apoptosis inducing ligand (TRAIL)

por Tarrus, Marc, van der Sloot, Almer M., Temming, Kai, Lacombe, Marie, Opdam, Frank, Quax, Wim J., Molema, Grietje, Poelstra, Klaas, Kok, Robbert J.
Publicado 2007

Phosphate Groups in the Lipid A Moiety Determine the Effects of LPS on Hepatic Stellate Cells: A Role for LPS-Dephosphorylating Activity in Liver Fibrosis

por Schippers, Marlies, Post, Eduard, Eichhorn, Ilse, Langeland, Jitske, Beljaars, Leonie, Malo, Madhu S., Hodin, Richard A., Millán, José Luis, Popov, Yury, Schuppan, Detlef, Poelstra, Klaas
Publicado 2020

Targeting 15d-Prostaglandin J(2) to Hepatic Stellate Cells: Two Options Evaluated

por Hagens, Werner I., Mattos, Adriana, Greupink, Rick, de Jager-Krikken, Alie, Reker-Smit, Catharina, van Loenen-Weemaes, AnneMiek, Gouw, Annette S. H., Poelstra, Klaas, Beljaars, Leonie
Publicado 2007

Interferon gamma peptidomimetic targeted to interstitial myofibroblasts attenuates renal fibrosis after unilateral ureteral obstruction in mice

por Poosti, Fariba, Bansal, Ruchi, Yazdani, Saleh, Prakash, Jai, Beljaars, Leonie, van den Born, Jacob, de Borst, Martin H., van Goor, Harry, Hillebrands, Jan-Luuk, Poelstra, Klaas
Publicado 2016

Rho-kinase inhibitor coupled to peptide-modified albumin carrier reduces portal pressure and increases renal perfusion in cirrhotic rats

por Klein, Sabine, Frohn, Franziska, Magdaleno, Fernando, Reker-Smit, Catharina, Schierwagen, Robert, Schierwagen, Irela, Uschner, Frank Erhard, van Dijk, Fransien, Fürst, Dieter O., Djudjaj, Sonja, Boor, Peter, Poelstra, Klaas, Beljaars, Leonie, Trebicka, Jonel
Publicado 2019

Osteoprotegerin Is more than a Possible Serum Marker in Liver Fibrosis: A Study into Its Function in Human and Murine Liver

por Adhyatmika, Adhyatmika, Beljaars, Leonie, Putri, Kurnia S. S., Habibie, Habibie, Boorsma, Carian E., Reker-Smit, Catharina, Luangmonkong, Theerut, Guney, Burak, Haak, Axel, Mangnus, Keri A., Post, Eduard, Poelstra, Klaas, Ravnskjaer, Kim, Olinga, Peter, Melgert, Barbro N.
Publicado 2020