Regulation of p53 expression, phosphorylation and sub-cellular localisation by a G-protein coupled receptor

por Solyakov, Lev, Sayan, Emre, Riley, Joan, Pointon, Amy, Tobin, Andrew B
Publicado 2009

Cardiac Non-myocyte Cells Show Enhanced Pharmacological Function Suggestive of Contractile Maturity in Stem Cell Derived Cardiomyocyte Microtissues

por Ravenscroft, Stephanie M., Pointon, Amy, Williams, Awel W., Cross, Michael J., Sidaway, James E.
Publicado 2016

Characterization and Validation of a Human 3D Cardiac Microtissue for the Assessment of Changes in Cardiac Pathology

por Archer, Caroline R., Sargeant, Rebecca, Basak, Jayati, Pilling, James, Barnes, Jennifer R., Pointon, Amy
Publicado 2018

Exosomal delivery of doxorubicin enables rapid cell entry and enhanced in vitro potency

por Schindler, Christina, Collinson, Andie, Matthews, Carl, Pointon, Amy, Jenkinson, Lesley, Minter, Ralph R., Vaughan, Tristan J., Tigue, Natalie J.
Publicado 2019

An Extensive Metabolomics Workflow to Discover Cardiotoxin-Induced Molecular Perturbations in Microtissues

por Bowen, Tara J., Hall, Andrew R., Lloyd, Gavin R., Weber, Ralf J. M., Wilson, Amanda, Pointon, Amy, Viant, Mark R.
Publicado 2021

Deriving waveform parameters from calcium transients in human iPSC-derived cardiomyocytes to predict cardiac activity with machine learning

por Yang, Hongbin, Stebbeds, Will, Francis, Jo, Pointon, Amy, Obrezanova, Olga, Beattie, Kylie A., Clements, Peter, Harvey, James S., Smith, Graham F., Bender, Andreas
Publicado 2022

Simultaneously discovering the fate and biochemical effects of pharmaceuticals through untargeted metabolomics

por Bowen, Tara J., Southam, Andrew D., Hall, Andrew R., Weber, Ralf J. M., Lloyd, Gavin R., Macdonald, Ruth, Wilson, Amanda, Pointon, Amy, Viant, Mark R.
Publicado 2023

Doxorubicin In Vivo Rapidly Alters Expression and Translation of Myocardial Electron Transport Chain Genes, Leads to ATP Loss and Caspase 3 Activation

por Pointon, Amy V., Walker, Tracy M., Phillips, Kate M., Luo, Jinli, Riley, Joan, Zhang, Shu-Dong, Parry, Joel D., Lyon, Jonathan J., Marczylo, Emma L., Gant, Timothy W.
Publicado 2010

On the potential of in vitro organ-chip models to define temporal pharmacokinetic-pharmacodynamic relationships

por McAleer, Christopher W., Pointon, Amy, Long, Christopher J., Brighton, Rocky L., Wilkin, Benjamin D., Bridges, L. Richard, Narasimhan Sriram, Narasimham, Fabre, Kristin, McDougall, Robin, Muse, Victorine P., Mettetal, Jerome T., Srivastava, Abhishek, Williams, Dominic, Schnepper, Mark T., Roles, Jeff L., Shuler, Michael L., Hickman, James J., Ewart, Lorna
Publicado 2019

Time for a Fully Integrated Nonclinical–Clinical Risk Assessment to Streamline QT Prolongation Liability Determinations: A Pharma Industry Perspective

por Vargas, Hugo M., Rolf, Michael G., Wisialowski, Todd A., Achanzar, William, Bahinski, Anthony, Bass, Alan, Benson, Charles T, Chaudhary, Khuram W., Couvreur, Nicolas, Dota, Corina, Engwall, Michael J, Michael Foley, C., Gallacher, David, Greiter‐Wilke, Andrea, Guillon, Jean‐Michel, Guth, Brian, Himmel, Herbert M., Hegele‐Hartung, Christa, Ito, Maki, Jenkinson, Stephen, Chiba, Katsuyoshi, Lagrutta, Armando, Levesque, Paul, Martel, Eric, Okai, Yoshiko, Peri, Ravikumar, Pointon, Amy, Qu, Yusheng, Teisman, Ard, Traebert, Martin, Yoshinaga, Takashi, Gintant, Gary A., Leishman, Derek J., Valentin, Jean‐Pierre
Publicado 2020