Stromal depletion by TALEN-edited universal hypoimmunogenic FAP-CAR T cells enables infiltration and anti-tumor cytotoxicity of tumor antigen-targeted CAR-T immunotherapy

por Das, Shipra, Valton, Julien, Duchateau, Philippe, Poirot, Laurent
Publicado 2023

Physiological β Cell Death Triggers Priming of Self-reactive T Cells by Dendritic Cells in a Type-1 Diabetes Model

por Turley, Shannon, Poirot, Laurent, Hattori, Masakazu, Benoist, Christophe, Mathis, Diane
Publicado 2003

Meganucleases and Other Tools for Targeted Genome Engineering: Perspectives and Challenges for Gene Therapy

por Silva, George, Poirot, Laurent, Galetto, Roman, Smith, Julianne, Montoya, Guillermo, Duchateau, Philippe, Pâques, Frédéric
Publicado 2011

Straightforward Generation of Ultrapure Off-the-Shelf Allogeneic CAR-T Cells

por Juillerat, Alexandre, Tkach, Diane, Yang, Ming, Boyne, Alex, Valton, Julien, Poirot, Laurent, Duchateau, Philippe
Publicado 2020

Pre-T cell receptor for improved expansion of TCR alpha disrupted T cells

por Galetto, Roman, Lebuhotel, Céline, Poirot, Laurent, Schiffer-Mannioui, Cécile, Arnould, Sylvain, Smith, Julianne, Scharenberg, Andrew
Publicado 2013

Pre-TCRα supports CD3-dependent reactivation and expansion of TCRα-deficient primary human T-cells

por Galetto, Román, Lebuhotel, Celine, Poirot, Laurent, Gouble, Agnès, Toribio, Maria L, Smith, Julianne, Scharenberg, Andrew
Publicado 2014

Design of chimeric antigen receptors with integrated controllable transient functions

por Juillerat, Alexandre, Marechal, Alan, Filhol, Jean-Marie, Valton, Julien, Duclert, Aymeric, Poirot, Laurent, Duchateau, Philippe
Publicado 2016

Optimized two‐step electroporation process to achieve efficient nonviral‐mediated gene insertion into primary T cells

por Yang, Ming, Tkach, Diane, Boyne, Alex, Kazancioglu, Selena, Duclert, Aymeric, Poirot, Laurent, Duchateau, Philippe, Juillerat, Alexandre
Publicado 2021

Treatment of B cells malignancies with anti-CD19 CAR+, TCR-, CD52- allogeneic T cells

por Mannioui, Cécile Schiffer, Lemaire, Laëtitia, Poirot, Laurent, Gouble, Agnes, Arnould, Sylvain, Galetto, Roman, Smith, Julianne, Scharenberg, Andrew
Publicado 2013

A Multidrug-resistant Engineered CAR T Cell for Allogeneic Combination Immunotherapy

por Valton, Julien, Guyot, Valérie, Marechal, Alan, Filhol, Jean-Marie, Juillerat, Alexandre, Duclert, Aymeric, Duchateau, Philippe, Poirot, Laurent
Publicado 2015

An oxygen sensitive self-decision making engineered CAR T-cell

por Juillerat, Alexandre, Marechal, Alan, Filhol, Jean Marie, Valogne, Yannick, Valton, Julien, Duclert, Aymeric, Duchateau, Philippe, Poirot, Laurent
Publicado 2017

Fine and Predictable Tuning of TALEN Gene Editing Targeting for Improved T Cell Adoptive Immunotherapy

por Gautron, Anne-Sophie, Juillerat, Alexandre, Guyot, Valérie, Filhol, Jean-Marie, Dessez, Emilie, Duclert, Aymeric, Duchateau, Philippe, Poirot, Laurent
Publicado 2017

Modulation of chimeric antigen receptor surface expression by a small molecule switch

por Juillerat, Alexandre, Tkach, Diane, Busser, Brian W., Temburni, Sonal, Valton, Julien, Duclert, Aymeric, Poirot, Laurent, Depil, Stéphane, Duchateau, Philippe
Publicado 2019

Optimized tuning of TALEN specificity using non-conventional RVDs

por Juillerat, Alexandre, Pessereau, Coline, Dubois, Gwendoline, Guyot, Valérie, Maréchal, Alan, Valton, Julien, Daboussi, Fayza, Poirot, Laurent, Duclert, Aymeric, Duchateau, Philippe
Publicado 2015

A Versatile Safeguard for Chimeric Antigen Receptor T-Cell Immunotherapies

por Valton, Julien, Guyot, Valerie, Boldajipour, Bijan, Sommer, Cesar, Pertel, Thomas, Juillerat, Alexandre, Duclert, Aymeric, Sasu, Barbra Johnson, Duchateau, Philippe, Poirot, Laurent
Publicado 2018

Gene editing of PKLR gene in human hematopoietic progenitors through 5’ and 3’ UTR modified TALEN mRNA

por Quintana-Bustamante, Oscar, Fañanas-Baquero, Sara, Orman, Israel, Torres, Raul, Duchateau, Philippe, Poirot, Laurent, Gouble, Agnès, Bueren, Juan A., Segovia, Jose C.
Publicado 2019

Repurposing endogenous immune pathways to tailor and control chimeric antigen receptor T cell functionality

por Sachdeva, Mohit, Busser, Brian W., Temburni, Sonal, Jahangiri, Billal, Gautron, Anne-Sophie, Maréchal, Alan, Juillerat, Alexandre, Williams, Alan, Depil, Stéphane, Duchateau, Philippe, Poirot, Laurent, Valton, Julien
Publicado 2019

Author Correction: Repurposing endogenous immune pathways to tailor and control chimeric antigen receptor T cell functionality

por Sachdeva, Mohit, Busser, Brian W., Temburni, Sonal, Jahangiri, Billal, Gautron, Anne-Sophie, Maréchal, Alan, Juillerat, Alexandre, Williams, Alan, Depil, Stéphane, Duchateau, Philippe, Poirot, Laurent, Valton, Julien
Publicado 2020

Preclinical Evidence of an Allogeneic Dual CD20xCD22 CAR to Target a Broad Spectrum of Patients with B-cell Malignancies

por Aranda-Orgilles, Beatriz, Chion-Sotinel, Isabelle, Skinner, Jordan, Grudman, Steven, Mumford, Ben, Dixon, Chantel, Postigo Fernandez, Jorge, Erler, Piril, Duchateau, Phillipe, Gouble, Agnes, Galetto, Roman, Poirot, Laurent
Publicado 2023

The intramembrane protease Sppl2a is required for B cell and DC development and survival via cleavage of the invariant chain

por Beisner, Daniel R., Langerak, Petra, Parker, Albert E., Dahlberg, Carol, Otero, Francella J., Sutton, Sue E., Poirot, Laurent, Barnes, Whitney, Young, Michael A., Niessen, Sherry, Wiltshire, Tim, Bodendorf, Ursula, Martoglio, Bruno, Cravatt, Benjamin, Cooke, Michael P.
Publicado 2013