Synthesis of Peptidyl-tRNA Mimics for Structural Biology Applications

por Polikanov, Yury S., Etheve-Quelquejeu, Mélanie, Micura, Ronald
Publicado 2023

A proton wire to couple aminoacyl-tRNA accommodation and peptide bond formation on the ribosome

por Polikanov, Yury S., Steitz, Thomas A., Innis, C. Axel
Publicado 2014

Structural basis for the inability of chloramphenicol to inhibit peptide bond formation in the presence of A-site glycine

por Syroegin, Egor A, Aleksandrova, Elena V, Polikanov, Yury S
Publicado 2022

Structural insights into the role of rRNA modifications in protein synthesis and ribosome assembly

por Polikanov, Yury S., Melnikov, Sergey V., Söll, Dieter, Steitz, Thomas A.
Publicado 2015

Insights into RNA binding by the anticancer drug cisplatin from the crystal structure of cisplatin-modified ribosome

por Melnikov, Sergey V., Söll, Dieter, Steitz, Thomas A., Polikanov, Yury S.
Publicado 2016

The Mechanisms of Action of Ribosome-Targeting Peptide Antibiotics

por Polikanov, Yury S., Aleksashin, Nikolay A., Beckert, Bertrand, Wilson, Daniel N.
Publicado 2018

Sarecycline interferes with tRNA accommodation and tethers mRNA to the 70S ribosome

por Batool, Zahra, Lomakin, Ivan B., Polikanov, Yury S., Bunick, Christopher G.
Publicado 2020

Practical Synthesis of N-Formylmethionylated Peptidyl-tRNA Mimics

por Thaler, Julia, Syroegin, Egor A., Breuker, Kathrin, Polikanov, Yury S., Micura, Ronald
Publicado 2023

High-resolution crystal structures of ribosome-bound chloramphenicol and erythromycin provide the ultimate basis for their competition

por Svetlov, Maxim S., Plessa, Elena, Chen, Chih-Wei, Bougas, Anthony, Krokidis, Marios G., Dinos, George P., Polikanov, Yury S.
Publicado 2019

Structure of Erm-modified 70S ribosome reveals the mechanism of macrolide resistance.

por Svetlov, Maxim S., Syroegin, Egor A., Aleksandrova, Elena V., Atkinson, Gemma C., Gregory, Steven T., Mankin, Alexander S., Polikanov, Yury S.
Publicado 2021

Structural insights into the mechanism of overcoming Erm-mediated resistance by macrolides acting together with hygromycin-A

por Chen, Chih-Wei, Leimer, Nadja, Syroegin, Egor A., Dunand, Clémence, Bulman, Zackery P., Lewis, Kim, Polikanov, Yury S., Svetlov, Maxim S.
Publicado 2023

Nucleosome-free DNA regions differentially affect distant communication in chromatin

por Nizovtseva, Ekaterina V., Clauvelin, Nicolas, Todolli, Stefjord, Polikanov, Yury S., Kulaeva, Olga I., Wengrzynek, Scott, Olson, Wilma K., Studitsky, Vasily M.
Publicado 2017

Mechanistic insights into the slow peptide bond formation with D-amino acids in the ribosomal active site

por Melnikov, Sergey V, Khabibullina, Nelli F, Mairhofer, Elisabeth, Vargas-Rodriguez, Oscar, Reynolds, Noah M, Micura, Ronald, Söll, Dieter, Polikanov, Yury S
Publicado 2019

The Odilorhabdin Antibiotic Biosynthetic Cluster and Acetyltransferase Self-Resistance Locus Are Niche and Species Specific

por Lanois-Nouri, Anne, Pantel, Lucile, Fu, Jun, Houard, Jessica, Ogier, Jean-Claude, Polikanov, Yury S., Racine, Emilie, Wang, Hailong, Gaudriault, Sophie, Givaudan, Alain, Gualtieri, Maxime
Publicado 2022

Co-produced natural ketolides methymycin and pikromycin inhibit bacterial growth by preventing synthesis of a limited number of proteins

por Almutairi, Mashal M., Svetlov, Maxim S., Hansen, Douglas A., Khabibullina, Nelli F., Klepacki, Dorota, Kang, Han-Young, Sherman, David H., Vázquez-Laslop, Nora, Polikanov, Yury S., Mankin, Alexander S.
Publicado 2017

Madumycin II inhibits peptide bond formation by forcing the peptidyl transferase center into an inactive state

por Osterman, Ilya A., Khabibullina, Nelli F., Komarova, Ekaterina S., Kasatsky, Pavel, Kartsev, Victor G., Bogdanov, Alexey A., Dontsova, Olga A., Konevega, Andrey L., Sergiev, Petr V., Polikanov, Yury S.
Publicado 2017

Insights into the molecular mechanism of translation inhibition by the ribosome-targeting antibiotic thermorubin

por Paranjpe, Madhura N, Marina, Valeria I, Grachev, Aleksandr A, Maviza, Tinashe P, Tolicheva, Olga A, Paleskava, Alena, Osterman, Ilya A, Sergiev, Petr V, Konevega, Andrey L, Polikanov, Yury S, Gagnon, Matthieu G
Publicado 2022

Structural basis of Cfr-mediated antimicrobial resistance and mechanisms for its evasion

por Aleksandrova, Elena V., Wu, Kelvin J. Y., Tresco, Ben I. C., Syroegin, Egor A., Killeavy, Erin E., Balasanyants, Samson M., Svetlov, Maxim S., Gregory, Steven T., Atkinson, Gemma C., Myers, Andrew G., Polikanov, Yury S.
Publicado 2023

Structure of ribosome-bound azole-modified peptide phazolicin rationalizes its species-specific mode of bacterial translation inhibition

por Travin, Dmitrii Y., Watson, Zoe L., Metelev, Mikhail, Ward, Fred R., Osterman, Ilya A., Khven, Irina M., Khabibullina, Nelli F., Serebryakova, Marina, Mergaert, Peter, Polikanov, Yury S., Cate, Jamie H. D., Severinov, Konstantin
Publicado 2019

Insights into the improved macrolide inhibitory activity from the high-resolution cryo-EM structure of dirithromycin bound to the E. coli 70S ribosome

por Pichkur, Evgeny B., Paleskava, Alena, Tereshchenkov, Andrey G., Kasatsky, Pavel, Komarova, Ekaterina S., Shiriaev, Dmitrii I., Bogdanov, Alexey A., Dontsova, Olga A., Osterman, Ilya A., Sergiev, Petr V., Polikanov, Yury S., Myasnikov, Alexander G., Konevega, Andrey L.
Publicado 2020