A Summary of Phenotypes Observed in the In Vivo Rodent Alpha-Synuclein Preformed Fibril Model

por Polinski, Nicole K.
Publicado 2021

The Michael J. Fox Foundation for Parkinson’s Research Strategy to Advance Therapeutic Development of PINK1 and Parkin

por Padmanabhan, Shalini, Polinski, Nicole K., Menalled, Liliana B., Baptista, Marco A.S., Fiske, Brian K.
Publicado 2019

The Future of GDNF in Parkinson's Disease

por Manfredsson, Fredric P., Polinski, Nicole K., Subramanian, Thyagarajan, Boulis, Nicholas, Wakeman, Dustin R., Mandel, Ronald J.
Publicado 2020

Endogenous Rab29 does not impact basal or stimulated LRRK2 pathway activity

por Kalogeropulou, Alexia F., Freemantle, Jordana B., Lis, Pawel, Vides, Edmundo G., Polinski, Nicole K., Alessi, Dario R.
Publicado 2020

Impact of age and vector construct on striatal and nigral transgene expression

por Polinski, Nicole K, Manfredsson, Fredric P, Benskey, Matthew J, Fischer, D Luke, Kemp, Christopher J, Steece-Collier, Kathy, Sandoval, Ivette M, Paumier, Katrina L, Sortwell, Caryl E
Publicado 2016

Best Practices for Generating and Using Alpha-Synuclein Pre-Formed Fibrils to Model Parkinson’s Disease in Rodents

por Polinski, Nicole K., Volpicelli-Daley, Laura A., Sortwell, Caryl E., Luk, Kelvin C., Cremades, Nunilo, Gottler, Lindsey M., Froula, Jessica, Duffy, Megan F., Lee, Virginia M.Y., Martinez, Terina N., Dave, Kuldip D.
Publicado 2018

The GBA1 D409V mutation exacerbates synuclein pathology to differing extents in two alpha-synuclein models

por Polinski, Nicole K., Martinez, Terina N., Ramboz, Sylvie, Sasner, Michael, Herberth, Mark, Switzer, Robert, Ahmad, Syed O., Pelligrino, Lee J., Clark, Sean W., Marcus, Jacob N., Smith, Sean M., Dave, Kuldip D., Frasier, Mark A.
Publicado 2022

Subthalamic Nucleus Deep Brain Stimulation Does Not Modify the Functional Deficits or Axonopathy Induced by Nigrostriatal α-Synuclein Overexpression

por Fischer, D. Luke, Manfredsson, Fredric P., Kemp, Christopher J., Cole-Strauss, Allyson, Lipton, Jack W., Duffy, Megan F., Polinski, Nicole K., Steece-Collier, Kathy, Collier, Timothy J., Gombash, Sara E., Buhlinger, Daniel J., Sortwell, Caryl E.
Publicado 2017

The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human

por Mir, Rafeeq, Tonelli, Francesca, Lis, Pawel, Macartney, Thomas, Polinski, Nicole K., Martinez, Terina N., Chou, Meng-Yun, Howden, Andrew J.M., König, Theresa, Hotzy, Christoph, Milenkovic, Ivan, Brücke, Thomas, Zimprich, Alexander, Sammler, Esther, Alessi, Dario R.
Publicado 2018

Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson's disease kinase

por Lis, Pawel, Burel, Sophie, Steger, Martin, Mann, Matthias, Brown, Fiona, Diez, Federico, Tonelli, Francesca, Holton, Janice L., Ho, Philip Winglok, Ho, Shu-Leong, Chou, Meng-Yun, Polinski, Nicole K., Martinez, Terina N., Davies, Paul, Alessi, Dario R.
Publicado 2018

Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms

por Malik, Asad U., Karapetsas, Athanasios, Nirujogi, Raja S., Mathea, Sebastian, Chatterjee, Deep, Pal, Prosenjit, Lis, Pawel, Taylor, Matthew, Purlyte, Elena, Gourlay, Robert, Dorward, Mark, Weidlich, Simone, Toth, Rachel, Polinski, Nicole K., Knapp, Stefan, Tonelli, Francesca, Alessi, Dario R.
Publicado 2021

Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration

por Duffy, Megan F., Collier, Timothy J., Patterson, Joseph R., Kemp, Christopher J., Luk, Kelvin C., Tansey, Malú G., Paumier, Katrina L., Kanaan, Nicholas M., Fischer, Luke D., Polinski, Nicole K., Barth, Olivia L., Howe, Jacob W., Vaikath, Nishant N., Majbour, Nour K., El-Agnaf, Omar M. A., Sortwell, Caryl E.
Publicado 2018

Correction to: Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration

por Duffy, Megan F., Collier, Timothy J., Patterson, Joseph R., Kemp, Christopher J., Luk, Kelvin C., Tansey, Malú G., Paumier, Katrina L., Kanaan, Nicholas M., Fischer, D. Luke, Polinski, Nicole K., Barth, Olivia L., Howe, Jacob W., Vaikath, Nishant N., Majbour, Nour K., El-Agnaf, Omar M. A., Sortwell, Caryl E.
Publicado 2018

Decreased glucocerebrosidase activity and substrate accumulation of glycosphingolipids in a novel GBA1 D409V knock-in mouse model

por Polinski, Nicole K., Martinez, Terina N., Gorodinsky, Alexander, Gareus, Ralph, Sasner, Michael, Herberth, Mark, Switzer, Robert, Ahmad, Syed O., Cosden, Mali, Kandebo, Monika, Drolet, Robert E., Buckett, Peter D., Shan, Weisong, Chen, Yi, Pellegrino, Lee J., Ellsworth, Gregory D., Dungan, Leo B., Hirst, Warren D., Clark, Sean W., Dave, Kuldip D.
Publicado 2021