Finding New Collaboration Models for Enabling Neglected Tropical Disease Drug Discovery

por Pollastri, Michael P.
Publicado 2014

Discovery of a Carbazole-Derived Lead Drug for Human African Trypanosomiasis

por Thomas, Sarah M., Purmal, Andrei, Pollastri, Michael, Mensa-Wilmot, Kojo
Publicado 2016

Erratum: Discovery of a Carbazole-Derived Lead Drug for Human African Trypanosomiasis

por Thomas, Sarah M., Purmal, Andrei, Pollastri, Michael, Mensa-Wilmot, Kojo
Publicado 2017

Kinases as Druggable Targets in Trypanosomatid Protozoan Parasites

por Merritt, Christopher, Silva, Lisseth E., Tanner, Angela L., Stuart, Kenneth, Pollastri, Michael P.
Publicado 2014

Calcium-Dependent Protein Kinase 5 Is Required for Release of Egress-Specific Organelles in Plasmodium falciparum

por Absalon, Sabrina, Blomqvist, Karin, Rudlaff, Rachel M., DeLano, Travis J., Pollastri, Michael P., Dvorin, Jeffrey D.
Publicado 2018

Lapatinib-Binding Protein Kinases in the African Trypanosome: Identification of Cellular Targets for Kinase-Directed Chemical Scaffolds

por Katiyar, Samiksha, Kufareva, Irina, Behera, Ranjan, Thomas, Sarah M., Ogata, Yuko, Pollastri, Michael, Abagyan, Ruben, Mensa-Wilmot, Kojo
Publicado 2013

The single cyclic nucleotide-specific phosphodiesterase of the intestinal parasite Giardia lamblia represents a potential drug target

por Kunz, Stefan, Balmer, Vreni, Sterk, Geert Jan, Pollastri, Michael P., Leurs, Rob, Müller, Norbert, Hemphill, Andrew, Spycher, Cornelia
Publicado 2017

A Target Repurposing Approach Identifies N-myristoyltransferase as a New Candidate Drug Target in Filarial Nematodes

por Galvin, Brendan D., Li, Zhiru, Villemaine, Estelle, Poole, Catherine B., Chapman, Melissa S., Pollastri, Michael P., Wyatt, Paul G., Carlow, Clotilde K. S.
Publicado 2014

Antiparasitic Lead Discovery: Toward Optimization of a Chemotype with Activity Against Multiple Protozoan Parasites

por Devine, William, Thomas, Sarah M., Erath, Jessey, Bachovchin, Kelly A., Lee, Patricia J., Leed, Susan E., Rodriguez, Ana, Sciotti, Richard J., Mensa-Wilmot, Kojo, Pollastri, Michael P.
Publicado 2017

The Susceptibility of Trypanosomatid Pathogens to PI3/mTOR Kinase Inhibitors Affords a New Opportunity for Drug Repurposing

por Diaz-Gonzalez, Rosario, Kuhlmann, F. Matthew, Galan-Rodriguez, Cristina, da Silva, Luciana Madeira, Saldivia, Manuel, Karver, Caitlin E., Rodriguez, Ana, Beverley, Stephen M., Navarro, Miguel, Pollastri, Michael P.
Publicado 2011

Establishment of a Structure–Activity Relationship of 1H-Imidazo[4,5-c]quinoline-Based Kinase Inhibitor NVP-BEZ235 as a Lead for African Sleeping Sickness

por Seixas, João D., Luengo-Arratta, Sandra A., Diaz, Rosario, Saldivia, Manuel, Rojas-Barros, Domingo I., Manzano, Pilar, Gonzalez, Silvia, Berlanga, Manuela, Smith, Terry K., Navarro, Miguel, Pollastri, Michael P.
Publicado 2014

Anilinoquinoline based inhibitors of trypanosomatid proliferation

por Ferrins, Lori, Sharma, Amrita, Thomas, Sarah M., Mehta, Naimee, Erath, Jessey, Tanghe, Scott, Leed, Susan E., Rodriguez, Ana, Mensa-Wilmot, Kojo, Sciotti, Richard J., Gillingwater, Kirsten, Pollastri, Michael P.
Publicado 2018

Fluorinated Adenosine A(2A) Receptor Antagonists Inspired by Preladenant as Potential Cancer Immunotherapeutics

por Yuan, Gengyang, Jankins, Tanner C., Patrick, Christopher G., Philbrook, Phaethon, Sears, Olivia, Hatfield, Stephen, Sitkovsky, Michail, Vasdev, Neil, Liang, Steven H., Ondrechen, Mary Jo, Pollastri, Michael P., Jones, Graham B.
Publicado 2017

Protozoan Parasite Growth Inhibitors Discovered by Cross-Screening Yield Potent Scaffolds for Lead Discovery

por Devine, William, Woodring, Jennifer L., Swaminathan, Uma, Amata, Emanuele, Patel, Gautam, Erath, Jessey, Roncal, Norma E., Lee, Patricia J., Leed, Susan E., Rodriguez, Ana, Mensa-Wilmot, Kojo, Sciotti, Richard J., Pollastri, Michael P.
Publicado 2015

Identification of Cinnabarinic Acid as a Novel Endogenous Aryl Hydrocarbon Receptor Ligand That Drives IL-22 Production

por Lowe, Margaret M., Mold, Jeff E., Kanwar, Bittoo, Huang, Yong, Louie, Alexander, Pollastri, Michael P., Wang, Cuihua, Patel, Gautam, Franks, Diana G., Schlezinger, Jennifer, Sherr, David H., Silverstone, Allen E., Hahn, Mark E., McCune, Joseph M.
Publicado 2014

Identification of “Preferred” Human Kinase Inhibitors for Sleeping Sickness Lead Discovery. Are Some Kinases Better than Others for Inhibitor Repurposing?

por Amata, Emanuele, Xi, Hualin, Colmenarejo, Gonzalo, Gonzalez-Diaz, Rosario, Cordon-Obras, Carlos, Berlanga, Manuela, Manzano, Pilar, Erath, Jessey, Roncal, Norma E., Lee, Patricia J., Leed, Susan E., Rodriguez, Ana, Sciotti, Richard J., Navarro, Miguel, Pollastri, Michael P.
Publicado 2016

Structure–Bioactivity Relationships of Lapatinib Derived Analogs against Schistosoma mansoni

por Buskes, Melissa J., Clements, Monica, Bachovchin, Kelly A., Jalani, Hitesh B., Leonard, Allison, Bag, Seema, Klug, Dana M., Singh, Baljinder, Campbell, Robert F., Sciotti, Richard J., El-Sakkary, Nelly, Caffrey, Conor R., Pollastri, Michael P., Ferrins, Lori
Publicado 2020

Chemical Optimization of CBL0137 for Human African Trypanosomiasis Lead Drug Discovery

por Singh, Baljinder, Sharma, Amrita, Gunaganti, Naresh, Rivers, Mitch, Gadekar, Pradip K., Greene, Brady, Chichioco, Michael, Sanz-Rodriguez, Carlos E., Fu, Courtney, LeBlanc, Catherine, Burchfield, Erin, Sharif, Nyle, Hoffman, Benjamin, Kumar, Gaurav, Purmal, Andrei, Mensa-Wilmot, Kojo, Pollastri, Michael P.
Publicado 2023

Identification and Characterization of Hundreds of Potent and Selective Inhibitors of Trypanosoma brucei Growth from a Kinase-Targeted Library Screening Campaign

por Diaz, Rosario, Luengo-Arratta, Sandra A., Seixas, João D., Amata, Emanuele, Devine, William, Cordon-Obras, Carlos, Rojas-Barros, Domingo I., Jimenez, Elena, Ortega, Fatima, Crouch, Sabrinia, Colmenarejo, Gonzalo, Fiandor, Jose Maria, Martin, Jose Julio, Berlanga, Manuela, Gonzalez, Silvia, Manzano, Pilar, Navarro, Miguel, Pollastri, Michael P.
Publicado 2014

Evaluation of a class of isatinoids identified from a high-throughput screen of human kinase inhibitors as anti-Sleeping Sickness agents

por Klug, Dana M., Diaz-Gonzalez, Rosario, Pérez-Moreno, Guiomar, Ceballos-Pérez, Gloria, García-Hernández, Raquel, Gomez-Pérez, Veronica, Ruiz-Pérez, Luis Miguel, Rojas-Barros, Domingo I., Gamarro, Francisco, González-Pacanowska, Dolores, Martínez-Martínez, María S., Manzano, Pilar, Ferrins, Lori, Caffrey, Conor R., Navarro, Miguel, Pollastri, Michael P.
Publicado 2019