Comprehensive Set of Tertiary Complex Structures and Palmitic Acid Binding Provide Molecular Insights into Ligand Design for RXR Isoforms

por Chaikuad, Apirat, Pollinger, Julius, Rühl, Michael, Ni, Xiaomin, Kilu, Whitney, Heering, Jan, Merk, Daniel
Publicado 2020

Systematic Assessment of Fragment Identification for Multitarget Drug Design

por Brunst, Steffen, Kramer, Jan S., Kilu, Whitney, Heering, Jan, Pollinger, Julius, Hiesinger, Kerstin, George, Sven, Steinhilber, Dieter, Merk, Daniel, Proschak, Ewgenij
Publicado 2021

Allosteric modulation of the farnesoid X receptor by a small molecule

por Gabler, Matthias, Kramer, Jan, Schmidt, Jurema, Pollinger, Julius, Weber, Julia, Kaiser, Astrid, Löhr, Frank, Proschak, Ewgenij, Schubert-Zsilavecz, Manfred, Merk, Daniel
Publicado 2018

A triple farnesoid X receptor and peroxisome proliferator-activated receptor α/δ activator reverses hepatic fibrosis in diet-induced NASH in mice

por Heitel, Pascal, Faudone, Giuseppe, Helmstädter, Moritz, Schmidt, Jurema, Kaiser, Astrid, Tjaden, Amelie, Schröder, Martin, Müller, Susanne, Schierle, Simone, Pollinger, Julius, Merk, Daniel
Publicado 2020

Targeting the Alternative Vitamin E Metabolite Binding Site Enables Noncanonical PPARγ Modulation

por Arifi, Silvia, Marschner, Julian A., Pollinger, Julius, Isigkeit, Laura, Heitel, Pascal, Kaiser, Astrid, Obeser, Lennart, Höfner, Georg, Proschak, Ewgenij, Knapp, Stefan, Chaikuad, Apirat, Heering, Jan, Merk, Daniel
Publicado 2023