Prediction of non-linear pharmacokinetics in humans of an antibody-drug conjugate (ADC) when evaluation of higher doses in animals is limited by tolerability: Case study with an an...

por Figueroa, Isabel, Leipold, Doug, Leong, Steve, Zheng, Bing, Triguero-Carrasco, Montserrat, Fourie-O'Donohue, Aimee, Kozak, Katherine R., Xu, Keyang, Schutten, Melissa, Wang, Hong, Polson, Andrew G., Kamath, Amrita V.
Publicado 2018

Development of T-cell engagers selective for cells co-expressing two antigens

por Dicara, Danielle M., Bhakta, Sunil, Go, Mary Ann, Ziai, James, Firestein, Ron, Forrest, Bill, Gu, Chen, Leong, Steven R., Lee, Genee, Yu, Shang-Fan, Polson, Andrew G., Agard, Nicholas J.
Publicado 2022

Anti-CD79B Antibody–Drug Conjugate DCDS0780A in Patients with B-Cell Non-Hodgkin Lymphoma: Phase 1 Dose-Escalation Study

por Herrera, Alex F., Patel, Manish R., Burke, John M., Advani, Ranjana, Cheson, Bruce D., Sharman, Jeff P., Penuel, Elicia, Polson, Andrew G., Liao, Chen Di, Li, Chunze, Schuth, Eva, Vaze, Anjali, Samineni, Divya, Elstrom, Rebecca, Cooper, James, Diefenbach, Catherine
Publicado 2022

Evaluation and use of an anti‐cynomolgus monkey CD79b surrogate antibody–drug conjugate to enable clinical development of polatuzumab vedotin

por Li, Dongwei, Lee, Donna, Dere, Randall C., Zheng, Bing, Yu, Shang‐Fan, Fuh, Franklin K., Kozak, Katherine R., Chung, Shan, Bumbaca Yadav, Daniela, Nazzal, Denise, Danilenko, Dimitry, Go, Mary Ann T., Williams, Marna, Polson, Andrew G., Poon, Kirsten Achilles, Prabhu, Saileta
Publicado 2019

Preclinical Evidence for the Efficacy of CD79b Immunotherapy in B-cell Precursor Acute Lymphoblastic Leukemia

por Lenk, Lennart, Winterberg, Dorothee, Vogiatzi, Fotini, Laqua, Anna, Spory, Lea, Mayar, Ahmad, Dietterle, Anna, Münch, Gina, Vokuhl, Christian, Richter, Julia, Polson, Andrew G., Schüler, Thomas, Kahlert, Ulf D., Peipp, Matthias, Valerius, Thomas, Schrappe, Martin, Cario, Gunnar, Jumaa, Hassan, Hobeika, Elias, Brüggemann, Monika, Alsadeq, Ameera, Schewe, Denis M.
Publicado 2022

Preclinical pharmacokinetics and pharmacodynamics of DCLL9718A: An antibody-drug conjugate for the treatment of acute myeloid leukemia

por Leipold, Douglas D., Figueroa, Isabel, Masih, Shabkhaiz, Latifi, Brandon, Yip, Victor, Shen, Ben-Quan, Dere, Randall C., Carrasco-Triguero, Montserrat, Lee, M. Violet, Saad, Ola M., Liu, Luna, He, Jintang, Su, Dian, Xu, Keyang, Vuillemenot, Brian R., Laing, Steven T., Schutten, Melissa, Kozak, Katherine R., Zheng, Bing, Polson, Andrew G., Kamath, Amrita V.
Publicado 2018

Phase I study of the anti-FcRH5 antibody-drug conjugate DFRF4539A in relapsed or refractory multiple myeloma

por Stewart, A. Keith, Krishnan, Amrita Y., Singhal, Seema, Boccia, Ralph V., Patel, Manish R., Niesvizky, Ruben, Chanan-Khan, Asher A., Ailawadhi, Sikander, Brumm, Jochen, Mundt, Kirsten E., Hong, Kyu, McBride, Jacqueline, Shon-Nguyen, Quyen, Xiao, Yuanyuan, Ramakrishnan, Vanitha, Polson, Andrew G., Samineni, Divya, Leipold, Douglas, Humke, Eric W., McClellan, James Scott, Berdeja, Jesus G.
Publicado 2019

Novel Anti-LY6G6D/CD3 T-Cell–Dependent Bispecific Antibody for the Treatment of Colorectal Cancer

por Wang, Peiyin, Sun, Liping L., Clark, Robyn, Hristopoulos, Maria, Chiu, Cecilia P.C., Dillon, Michael, Lin, WeiYu, Lo, Amy A., Chalsani, Sreedevi, Das Thakur, Meghna, Zimmerman Savill, Kristin M., Rougé, Lionel, Lupardus, Patrick, Piskol, Robert, Husain, Bushra, Ellerman, Diego, Shivva, Vittal, Leong, Steven R., Ovacik, Meric, Totpal, Klara, Wu, Yan, Spiess, Christoph, Lee, Genee, Leipold, Douglas D., Polson, Andrew G.
Publicado 2022

Preclinical optimization of Ly6E-targeted ADCs for increased durability and efficacy of anti-tumor response

por Dela Cruz Chuh, Josefa, Go, MaryAnn, Chen, Yvonne, Guo, Jun, Rafidi, Hanine, Mandikian, Danielle, Sun, Yonglian, Lin, Zhonghua, Schneider, Kellen, Zhang, Pamela, Vij, Rajesh, Sharpnack, Danielle, Chan, Pamela, de la Cruz, Cecile, Sadowsky, Jack, Seshasayee, Dhaya, Koerber, James T., Pillow, Thomas H., Phillips, Gail D., Rowntree, Rebecca K, Boswell, C. Andrew, Kozak, Katherine R., Polson, Andrew G., Polakis, Paul, Yu, Shang-Fan, Dragovich, Peter S., Agard, Nicholas J.
Publicado 2020