Selective inhibition of RNA polymerase I transcription as a potential approach to treat African trypanosomiasis

por Kerry, Louise E., Pegg, Elaine E., Cameron, Donald P., Budzak, James, Poortinga, Gretchen, Hannan, Katherine M., Hannan, Ross D., Rudenko, Gloria
Publicado 2017

c-MYC coordinately regulates ribosomal gene chromatin remodeling and Pol I availability during granulocyte differentiation

por Poortinga, Gretchen, Wall, Meaghan, Sanij, Elaine, Siwicki, Kasia, Ellul, Jason, Brown, Daniel, Holloway, Timothy P., Hannan, Ross D., McArthur, Grant A.
Publicado 2011

rDNA Chromatin Activity Status as a Biomarker of Sensitivity to the RNA Polymerase I Transcription Inhibitor CX-5461

por Son, Jinbae, Hannan, Katherine M., Poortinga, Gretchen, Hein, Nadine, Cameron, Donald P., Ganley, Austen R. D., Sheppard, Karen E., Pearson, Richard B., Hannan, Ross D., Sanij, Elaine
Publicado 2020

Defining the essential function of FBP/KSRP proteins: Drosophila Psi interacts with the mediator complex to modulate MYC transcription and tissue growth

por Guo, Linna, Zaysteva, Olga, Nie, Zuqin, Mitchell, Naomi C., Amanda Lee, Jue Er, Ware, Thomas, Parsons, Linda, Luwor, Rodney, Poortinga, Gretchen, Hannan, Ross D., Levens, David L., Quinn, Leonie M.
Publicado 2016

UBF levels determine the number of active ribosomal RNA genes in mammals

por Sanij, Elaine, Poortinga, Gretchen, Sharkey, Kerith, Hung, Sandy, Holloway, Timothy P., Quin, Jaclyn, Robb, Elysia, Wong, Lee H., Thomas, Walter G., Stefanovsky, Victor, Moss, Tom, Rothblum, Lawrence, Hannan, Katherine M., McArthur, Grant A., Pearson, Richard B., Hannan, Ross D.
Publicado 2008

A novel role for the Pol I transcription factor UBTF in maintaining genome stability through the regulation of highly transcribed Pol II genes

por Sanij, Elaine, Diesch, Jeannine, Lesmana, Analia, Poortinga, Gretchen, Hein, Nadine, Lidgerwood, Grace, Cameron, Donald P., Ellul, Jason, Goodall, Gregory J., Wong, Lee H., Dhillon, Amardeep S., Hamdane, Nourdine, Rothblum, Lawrence I., Pearson, Richard B., Haviv, Izhak, Moss, Tom, Hannan, Ross D.
Publicado 2015

Changes in long-range rDNA-genomic interactions associate with altered RNA polymerase II gene programs during malignant transformation

por Diesch, Jeannine, Bywater, Megan J., Sanij, Elaine, Cameron, Donald P., Schierding, William, Brajanovski, Natalie, Son, Jinbae, Sornkom, Jirawas, Hein, Nadine, Evers, Maurits, Pearson, Richard B., McArthur, Grant A., Ganley, Austen R. D., O’Sullivan, Justin M., Hannan, Ross D., Poortinga, Gretchen
Publicado 2019

Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis

por Kusnadi, Eric P, Trigos, Anna S, Cullinane, Carleen, Goode, David L, Larsson, Ola, Devlin, Jennifer R, Chan, Keefe T, De Souza, David P, McConville, Malcolm J, McArthur, Grant A, Thomas, George, Sanij, Elaine, Poortinga, Gretchen, Hannan, Ross D, Hannan, Katherine M, Kang, Jian, Pearson, Richard B
Publicado 2020

Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling

por Quin, Jaclyn, Chan, Keefe T., Devlin, Jennifer R., Cameron, Donald P., Diesch, Jeannine, Cullinane, Carleen, Ahern, Jessica, Khot, Amit, Hein, Nadine, George, Amee J., Hannan, Katherine M, Poortinga, Gretchen, Sheppard, Karen E., Khanna, Kum Kum, Johnstone, Ricky W., Drygin, Denis, McArthur, Grant A., Pearson, Richard B., Sanij, Elaine, Hannan, Ross D.
Publicado 2016

Genomic characterisation of Eμ-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene

por Lefebure, Marcus, Tothill, Richard W., Kruse, Elizabeth, Hawkins, Edwin D., Shortt, Jake, Matthews, Geoffrey M., Gregory, Gareth P., Martin, Benjamin P., Kelly, Madison J., Todorovski, Izabela, Doyle, Maria A., Lupat, Richard, Li, Jason, Schroeder, Jan, Wall, Meaghan, Craig, Stuart, Poortinga, Gretchen, Cameron, Don, Bywater, Megan, Kats, Lev, Gearhart, Micah D., Bardwell, Vivian J., Dickins, Ross A., Hannan, Ross D., Papenfuss, Anthony T., Johnstone, Ricky W.
Publicado 2017

CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer

por Sanij, Elaine, Hannan, Katherine M., Xuan, Jiachen, Yan, Shunfei, Ahern, Jessica E., Trigos, Anna S., Brajanovski, Natalie, Son, Jinbae, Chan, Keefe T., Kondrashova, Olga, Lieschke, Elizabeth, Wakefield, Matthew J., Frank, Daniel, Ellis, Sarah, Cullinane, Carleen, Kang, Jian, Poortinga, Gretchen, Nag, Purba, Deans, Andrew J., Khanna, Kum Kum, Mileshkin, Linda, McArthur, Grant A., Soong, John, Berns, Els M. J. J., Hannan, Ross D., Scott, Clare L., Sheppard, Karen E., Pearson, Richard B.
Publicado 2020

Regulation of PRMT5–MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma

por AbuHammad, Shatha, Cullinane, Carleen, Martin, Claire, Bacolas, Zoe, Ward, Teresa, Chen, Huiqin, Slater, Alison, Ardley, Kerry, Kirby, Laura, Chan, Keefe T., Brajanovski, Natalie, Smith, Lorey K., Rao, Aparna D., Lelliott, Emily J., Kleinschmidt, Margarete, Vergara, Ismael A., Papenfuss, Anthony T., Lau, Peter, Ghosh, Prerana, Haupt, Sue, Haupt, Ygal, Sanij, Elaine, Poortinga, Gretchen, Pearson, Richard B., Falk, Hendrik, Curtis, David J., Stupple, Paul, Devlin, Mark, Street, Ian, Davies, Michael A., McArthur, Grant A., Sheppard, Karen E.
Publicado 2019