Contribution of Liver Nonparenchymal Cells to Hepatic Fibrosis: Interactions with the Local Microenvironment

par Fausther, Michel, Pritchard, Michele T., Popov, Yury V., Bridle, Kim
Publié 2017

Metabolic Hijacking of Hexose Metabolism to Ascorbate Synthesis Is the Unifying Biochemical Basis of Murine Liver Fibrosis

par Beyoğlu, Diren, Huang, Pinzhu, Skelton-Badlani, Disha, Zong, Christine, Popov, Yury V., Idle, Jeffrey R.
Publié 2023

Comparison of murine steatohepatitis models identifies a dietary intervention with robust fibrosis, ductular reaction, and rapid progression to cirrhosis and cancer

par Wei, Guangyan, An, Ping, Vaid, Kahini A., Nasser, Imad, Huang, Pinzhu, Tan, Li, Zhao, Shuangshuang, Schuppan, Detlef, Popov, Yury V.
Publié 2020

Hepatocyte mitochondria-derived danger signals directly activate hepatic stellate cells and drive progression of liver fibrosis

par An, Ping, Wei, Lin-Lin, Zhao, Shuangshuang, Sverdlov, Deanna Y., Vaid, Kahini A., Miyamoto, Makoto, Kuramitsu, Kaori, Lai, Michelle, Popov, Yury V.
Publié 2020

Automated whole slide image analysis for a translational quantification of liver fibrosis

par Serdjebi, Cindy, Bertotti, Karine, Huang, Pinzhu, Wei, Guangyan, Skelton-Badlani, Disha, Leclercq, Isabelle A., Barbes, Damien, Lepoivre, Bastien, Popov, Yury V., Julé, Yvon
Publié 2022

Selective targeting of lysyl oxidase-like 2 (LOXL2) suppresses hepatic fibrosis progression and accelerates its reversal

par Ikenaga, Naoki, Peng, Zhen-Wei, Vaid, Kahini A, Liu, Susan B, Yoshida, Shuhei, Sverdlov, Deanna Y, Mikels-Vigdal, Amanda, Smith, Victoria, Schuppan, Detlef, Popov, Yury V
Publié 2017

A novel non‐bile acid FXR agonist EDP‐305 potently suppresses liver injury and fibrosis without worsening of ductular reaction

par An, Ping, Wei, Guangyan, Huang, Pinzhu, Li, Wenda, Qi, Xiaolong, Lin, Yi, Vaid, Kahini A., Wang, Jun, Zhang, Shucha, Li, Yang, Or, Yat Sun, Jiang, Li‐Juan, Popov, Yury V.
Publié 2020

The ectonucleotidase ENTPD1/CD39 limits biliary injury and fibrosis in mouse models of sclerosing cholangitis

par Peng, Zhen‐Wei, Rothweiler, Sonja, Wei, Guangyan, Ikenaga, Naoki, Liu, Susan B., Sverdlov, Deanna Y., Vaid, Kahini A., Longhi, Maria Serena, Kuang, Ming, Robson, Simon C., Popov, Yury V.
Publié 2017

Heme oxygenase-1 mitigates liver injury and fibrosis via modulation of LNX1/Notch1 pathway in myeloid cells

par Canesin, Giacomo, Feldbrügge, Linda, Wei, Guangyan, Janovicova, Lubica, Janikova, Monika, Csizmadia, Eva, Ariffin, Juliana, Hedblom, Andreas, Herbert, Zachary T., Robson, Simon C., Celec, Peter, Swanson, Kenneth D., Nasser, Imad, Popov, Yury V., Wegiel, Barbara
Publié 2022

Synthetic human ABCB4 mRNA therapy rescues severe liver disease phenotype in a BALB/c.Abcb4(−/−) mouse model of PFIC3

par Wei, Guangyan, Cao, Jingsong, Huang, Pinzhu, An, Ping, Badlani, Disha, Vaid, Kahini A., Zhao, Shuangshuang, Wang, David Q-H., Zhuo, Jenny, Yin, Ling, Frassetto, Andrea, Markel, Arianna, Presnyak, Vladimir, Gandham, Srujan, Hua, Serenus, Lukacs, Christine, Finn, Patrick F., Giangrande, Paloma H., Martini, Paolo G.V., Popov, Yury V.
Publié 2020

Protective and aggressive bacterial subsets and metabolites modify hepatobiliary inflammation and fibrosis in a murine model of PSC

par Awoniyi, Muyiwa, Wang, Jeremy, Ngo, Billy, Meadows, Vik, Tam, Jason, Viswanathan, Amba, Lai, Yunjia, Montgomery, Stephanie, Farmer, Morgan, Kummen, Martin, Thingholm, Louise, Schramm, Christoph, Bang, Corinna, Franke, Andre, Lu, Kun, Zhou, Huiping, Bajaj, Jasmohan S, Hylemon, Phillip B, Ting, Jenny, Popov, Yury V, Hov, Johannes Roksund, Francis, Heather L, Sartor, Ryan Balfour
Publié 2023

Lipoprotein Z, a hepatotoxic lipoprotein, predicts outcome in alcohol‐associated hepatitis

par Hu, Kunpeng, Perez‐Matos, Maria C., Argemi, Josepmaria, Vilar‐Gomez, Eduardo, Shalaurova, Irina, Bullitt, Esther, Landeen, Lee, Sugahara, Go, Deng, Huiyan, Mathur, Karan, Tran, Stephanie, Cai, Huimei, He, Hanchang, Yalcin, Yusuf, Vieira Barbosa, Joana, Ventura‐Cots, Meritxell, Marx, Katherine, Gad, Aniket P., Niezen, Sebastian, Izunza Barba, Sofia, Ang, Lay‐Hong, Popov, Yury V., Fricker, Zachary, Lai, Michelle, Curry, Michael, Afdhal, Nezam, Szabo, Gyongyi, Mukamal, Kenneth J., Sanyal, Arun J., Otvos, James D., Malik, Raza, Saito, Takeshi, Connelly, Margery A., Chalasani, Naga P., Bataller, Ramon, Jiang, Z. Gordon
Publié 2021

A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2

par Delorey, Toni M., Ziegler, Carly G. K., Heimberg, Graham, Normand, Rachelly, Yang, Yiming, Segerstolpe, Asa, Abbondanza, Domenic, Fleming, Stephen J., Subramanian, Ayshwarya, Montoro, Daniel T., Jagadeesh, Karthik A., Dey, Kushal K., Sen, Pritha, Slyper, Michal, Pita-Juárez, Yered H., Phillips, Devan, Bloom-Ackerman, Zohar, Barkas, Nick, Ganna, Andrea, Gomez, James, Normandin, Erica, Naderi, Pourya, Popov, Yury V., Raju, Siddharth S., Niezen, Sebastian, Tsai, Linus T.-Y., Siddle, Katherine J., Sud, Malika, Tran, Victoria M., Vellarikkal, Shamsudheen K., Amir-Zilberstein, Liat, Atri, Deepak S., Beechem, Joseph, Brook, Olga R., Chen, Jonathan, Divakar, Prajan, Dorceus, Phylicia, Engreitz, Jesse M., Essene, Adam, Fitzgerald, Donna M., Fropf, Robin, Gazal, Steven, Gould, Joshua, Grzyb, John, Harvey, Tyler, Hecht, Jonathan, Hether, Tyler, Jane-Valbuena, Judit, Leney-Greene, Michael, Ma, Hui, McCabe, Cristin, McLoughlin, Daniel E., Miller, Eric M., Muus, Christoph, Niemi, Mari, Padera, Robert, Pan, Liuliu, Pant, Deepti, Pe’er, Carmel, Pfiffner-Borges, Jenna, Pinto, Christopher J., Plaisted, Jacob, Reeves, Jason, Ross, Marty, Rudy, Melissa, Rueckert, Erroll H., Siciliano, Michelle, Sturm, Alexander, Todres, Ellen, Waghray, Avinash, Warren, Sarah, Zhang, Shuting, Zollinger, Daniel R., Cosimi, Lisa, Gupta, Rajat M., Hacohen, Nir, Hide, Winston, Price, Alkes L., Rajagopal, Jayaraj, Tata, Purushothama Rao, Riedel, Stefan, Szabo, Gyongyi, Tickle, Timothy L., Hung, Deborah, Sabeti, Pardis C., Novak, Richard, Rogers, Robert, Ingber, Donald E., Jiang, Z. Gordon, Juric, Dejan, Babadi, Mehrtash, Farhi, Samouil L., Stone, James R., Vlachos, Ioannis S., Solomon, Isaac H., Ashenberg, Orr, Porter, Caroline B.M., Li, Bo, Shalek, Alex K., Villani, Alexandra-Chloé, Rozenblatt-Rosen, Orit, Regev, Aviv
Publié 2021