A Buckycatcher in Solution—A Computational Perspective

por Menezes, Filipe, Popowicz, Grzegorz M.
Publicado 2023

Paramagnetic NMR in drug discovery

por Softley, Charlotte A., Bostock, Mark J., Popowicz, Grzegorz M., Sattler, Michael
Publicado 2020

The conserved ubiquitin-like protein Hub1 plays a critical role in splicing in human cells

por Ammon, Tim, Mishra, Shravan Kumar, Kowalska, Kaja, Popowicz, Grzegorz M., Holak, Tad A., Jentsch, Stefan
Publicado 2014

Inhibitors of glycosomal protein import provide new leads against trypanosomiasis

por Kalel, Vishal C., Emmanouilidis, Leonidas, Dawidowski, Maciej, Schliebs, Wolfgang, Sattler, Michael, Popowicz, Grzegorz M., Erdmann, Ralf
Publicado 2017

Crystal Structure of Kluyveromyces lactis Glucokinase (KlGlk1)

por Zak, Krzysztof M., Kalińska, Magdalena, Wątor, Elżbieta, Kuśka, Katarzyna, Krutyhołowa, Rościsław, Dubin, Grzegorz, Popowicz, Grzegorz M., Grudnik, Przemysław
Publicado 2019

Characterization of SARS-CoV-2 replication complex elongation and proofreading activity

por Jones, Alisha N., Mourão, André, Czarna, Anna, Matsuda, Alex, Fino, Roberto, Pyrc, Krzysztof, Sattler, Michael, Popowicz, Grzegorz M.
Publicado 2022

Silmitasertib (CX-4945), a Clinically Used CK2-Kinase Inhibitor with Additional Effects on GSK3β and DYRK1A Kinases: A Structural Perspective

por Grygier, Przemyslaw, Pustelny, Katarzyna, Nowak, Jakub, Golik, Przemyslaw, Popowicz, Grzegorz M., Plettenburg, Oliver, Dubin, Grzegorz, Menezes, Filipe, Czarna, Anna
Publicado 2023

Steric hindrance and structural flexibility shape the functional properties of a guanine-rich oligonucleotide

por Troisi, Romualdo, Napolitano, Valeria, Rossitto, Emanuele, Osman, Waleed, Nagano, Masanobu, Wakui, Koji, Popowicz, Grzegorz M, Yoshimoto, Keitaro, Sica, Filomena
Publicado 2023

Extrinsic stabilization of antiviral ACE2-Fc fusion proteins targeting SARS-CoV-2

por Svilenov, Hristo L., Delhommel, Florent, Siebenmorgen, Till, Rührnößl, Florian, Popowicz, Grzegorz M., Reiter, Alwin, Sattler, Michael, Brockmeyer, Carsten, Buchner, Johannes
Publicado 2023

Novel Trypanocidal Inhibitors that Block Glycosome Biogenesis by Targeting PEX3–PEX19 Interaction

por Li, Mengqiao, Gaussmann, Stefan, Tippler, Bettina, Ott, Julia, Popowicz, Grzegorz M, Schliebs, Wolfgang, Sattler, Michael, Erdmann, Ralf, Kalel, Vishal C
Publicado 2021

Binding mechanism and biological effects of flavone DYRK1A inhibitors for the design of new antidiabetics

por Pustelny, Katarzyna, Grygier, Przemyslaw, Barzowska, Agata, Pucelik, Barbara, Matsuda, Alex, Mrowiec, Krzysztof, Slugocka, Emilia, Popowicz, Grzegorz M., Dubin, Grzegorz, Czarna, Anna
Publicado 2023

Enabling Large-Scale Design, Synthesis and Validation of Small Molecule Protein-Protein Antagonists

por Koes, David, Khoury, Kareem, Huang, Yijun, Wang, Wei, Bista, Michal, Popowicz, Grzegorz M., Wolf, Siglinde, Holak, Tad A., Dömling, Alexander, Camacho, Carlos J.
Publicado 2012

Latency, thermal stability, and identification of an inhibitory compound of mirolysin, a secretory protease of the human periodontopathogen Tannerella forsythia

por Zak, Krzysztof M., Bostock, Mark J., Waligorska, Irena, Thøgersen, Ida B., Enghild, Jan J., Popowicz, Grzegorz M., Grudnik, Przemyslaw, Potempa, Jan, Ksiazek, Miroslaw
Publicado 2021

Small molecule mediated inhibition of protein cargo recognition by peroxisomal transport receptor PEX5 is toxic to Trypanosoma

por Napolitano, Valeria, Softley, Charlotte A., Blat, Artur, Kalel, Vishal C., Schorpp, Kenji, Siebenmorgen, Till, Hadian, Kamyar, Erdmann, Ralf, Sattler, Michael, Popowicz, Grzegorz M., Dubin, Grzegorz
Publicado 2022

Discovery of Highly Potent p53-MDM2 Antagonists and Structural Basis for Anti-Acute Myeloid Leukemia Activities

por Huang, Yijun, Wolf, Siglinde, Beck, Barbara, Köhler, Lisa-Maria, Khoury, Kareem, Popowicz, Grzegorz M., Goda, Sayed K, Subklewe, Marion, Twarda, Aleksandra, Holak, Tad A., Dömling, Alexander
Publicado 2014

Structure and Molecular Recognition Mechanism of IMP-13 Metallo-β-Lactamase

por Softley, Charlotte A., Zak, Krzysztof M., Bostock, Mark J., Fino, Roberto, Zhou, Richard Xu, Kolonko, Marta, Mejdi-Nitiu, Ramona, Meyer, Hannelore, Sattler, Michael, Popowicz, Grzegorz M.
Publicado 2020

Exploring the Surface of the Ectodomain of the PD-L1 Immune Checkpoint with Small-Molecule Fragments

por Kitel, Radoslaw, Rodríguez, Ismael, del Corte, Xabier, Atmaj, Jack, Żarnik, Magdalena, Surmiak, Ewa, Muszak, Damian, Magiera-Mularz, Katarzyna, Popowicz, Grzegorz M., Holak, Tad A., Musielak, Bogdan
Publicado 2022

A fragment-based approach identifies an allosteric pocket that impacts malate dehydrogenase activity

por Reyes Romero, Atilio, Lunev, Serjey, Popowicz, Grzegorz M., Calderone, Vito, Gentili, Matteo, Sattler, Michael, Plewka, Jacek, Taube, Michał, Kozak, Maciej, Holak, Tad A., Dömling, Alexander S. S., Groves, Matthew R.
Publicado 2021

HuR biological function involves RRM3-mediated dimerization and RNA binding by all three RRMs

por Pabis, Marta, Popowicz, Grzegorz M, Stehle, Ralf, Fernández-Ramos, David, Asami, Sam, Warner, Lisa, García-Mauriño, Sofía M, Schlundt, Andreas, Martínez-Chantar, María L, Díaz-Moreno, Irene, Sattler, Michael
Publicado 2019

Bis-choline tetrathiomolybdate prevents copper-induced blood–brain barrier damage

por Borchard, Sabine, Raschke, Stefanie, Zak, Krzysztof M, Eberhagen, Carola, Einer, Claudia, Weber, Elisabeth, Müller, Sandra M, Michalke, Bernhard, Lichtmannegger, Josef, Wieser, Albrecht, Rieder, Tamara, Popowicz, Grzegorz M, Adamski, Jerzy, Klingenspor, Martin, Coles, Andrew H, Viana, Ruth, Vendelbo, Mikkel H, Sandahl, Thomas D, Schwerdtle, Tanja, Plitz, Thomas, Zischka, Hans
Publicado 2021