Translational Analysis of Moderate to Severe Asthma GWAS Signals Into Candidate Causal Genes and Their Functional, Tissue-Dependent and Disease-Related Associations

por Portelli, Michael A., Rakkar, Kamini, Hu, Sile, Guo, Yike, Adcock, Ian M., Sayers, Ian
Publicado 2021

Human bronchial epithelial cells from patients with asthma have an altered gene expression profile

por Bhaker, Sangita, Portelli, Michael A., Rakkar, Kamini, Shaw, Dominick, Johnson, Simon, Brightling, Christopher, Sayers, Ian
Publicado 2022

Elevated PLAUR is observed in the airway epithelium of asthma patients and blocking improves barrier integrity

por Portelli, Michael A., Bhaker, Sangita, Pang, Vincent, Bates, David O., Johnson, Simon R., Mazar, Andrew P., Shaw, Dominick, Brightling, Christopher, Sayers, Ian
Publicado 2023

Extended lifespan of bronchial epithelial cells maintains normal cellular phenotype and transcriptome integrity

por O'Loughlin, Jonathan, Hall, Robert J., Bhaker, Sangita, Portelli, Michael A., Henry, Amanda, Pang, Vincent, Bates, David O., Sharp, Tyson V., Sayers, Ian
Publicado 2021

Urokinase plasminogen activator receptor polymorphisms and airway remodelling in asthma

por Ierodiakonou, Despo, Portelli, Michael A., Postma, Dirkje S., Koppelman, Gerard H., Gerritsen, Jorrit, ten Hacken, Nick H.T., Timens, Wim, Boezen, H. Marike, Vonk, Judith M., Sayers, Ian
Publicado 2016

Genome-wide protein QTL mapping identifies human plasma kallikrein as a post-translational regulator of serum uPAR levels

por Portelli, Michael A., Siedlinski, Mateusz, Stewart, Ceri E., Postma, Dirkje S., Nieuwenhuis, Maartje A., Vonk, Judith M., Nurnberg, Peter, Altmuller, Janine, Moffatt, Miriam F., Wardlaw, Andrew J., Parker, Stuart G., Connolly, Martin J., Koppelman, Gerard H., Sayers, Ian
Publicado 2014

Whole Exome Re-Sequencing Implicates CCDC38 and Cilia Structure and Function in Resistance to Smoking Related Airflow Obstruction

por Wain, Louise V., Sayers, Ian, Soler Artigas, María, Portelli, Michael A., Zeggini, Eleftheria, Obeidat, Ma'en, Sin, Don D., Bossé, Yohan, Nickle, David, Brandsma, Corry-Anke, Malarstig, Anders, Vangjeli, Ciara, Jelinsky, Scott A., John, Sally, Kilty, Iain, McKeever, Tricia, Shrine, Nick R. G., Cook, James P., Patel, Shrina, Spector, Tim D., Hollox, Edward J., Hall, Ian P., Tobin, Martin D.
Publicado 2014

Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study

por Shrine, Nick, Portelli, Michael A, John, Catherine, Soler Artigas, María, Bennett, Neil, Hall, Robert, Lewis, Jon, Henry, Amanda P, Billington, Charlotte K, Ahmad, Azaz, Packer, Richard J, Shaw, Dominick, Pogson, Zara E K, Fogarty, Andrew, McKeever, Tricia M, Singapuri, Amisha, Heaney, Liam G, Mansur, Adel H, Chaudhuri, Rekha, Thomson, Neil C, Holloway, John W, Lockett, Gabrielle A, Howarth, Peter H, Djukanovic, Ratko, Hankinson, Jenny, Niven, Robert, Simpson, Angela, Chung, Kian Fan, Sterk, Peter J, Blakey, John D, Adcock, Ian M, Hu, Sile, Guo, Yike, Obeidat, Maen, Sin, Don D, van den Berge, Maarten, Nickle, David C, Bossé, Yohan, Tobin, Martin D, Hall, Ian P, Brightling, Christopher E, Wain, Louise V, Sayers, Ian
Publicado 2019

Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium

por Portelli, Michael A., Dijk, F. Nicole, Ketelaar, Maria E., Shrine, Nick, Hankinson, Jenny, Bhaker, Sangita, Grotenboer, Néomi S., Obeidat, Ma’en, Henry, Amanda P., Billington, Charlotte K., Shaw, Dominick, Johnson, Simon R., Pogson, Zara E.K., Fogarty, Andrew, McKeever, Tricia M., Nickle, David C., Bossé, Yohan, van den Berge, Maarten, Faiz, Alen, Brouwer, Sharon, Vonk, Judith M., de Vos, Paul, Brandsma, Corry-Anke, Vermeulen, Cornelis J., Singapuri, Amisha, Heaney, Liam G., Mansur, Adel H., Chaudhuri, Rekha, Thomson, Neil C., Holloway, John W., Lockett, Gabrielle A., Howarth, Peter H., Niven, Robert, Simpson, Angela, Blakey, John D., Tobin, Martin D., Postma, Dirkje S., Hall, Ian P., Wain, Louise V., Nawijn, Martijn C., Brightling, Christopher E., Koppelman, Gerard H., Sayers, Ian
Publicado 2020

Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets

por Wain, Louise V, Shrine, Nick, Soler Artigas, María, Erzurumluoglu, A Mesut, Noyvert, Boris, Bossini-Castillo, Lara, Obeidat, Ma’en, Henry, Amanda P, Portelli, Michael A, Hall, Robert J, Billington, Charlotte K, Rimington, Tracy L, Fenech, Anthony G, John, Catherine, Blake, Tineka, Jackson, Victoria E, Allen, Richard J, Prins, Bram P, Campbell, Archie, Porteous, David J, Jarvelin, Marjo-Riitta, Wielscher, Matthias, James, Alan L, Hui, Jennie, Wareham, Nicholas J, Zhao, Jing Hua, Wilson, James F, Joshi, Peter K, Stubbe, Beate, Rawal, Rajesh, Schulz, Holger, Imboden, Medea, Probst-Hensch, Nicole M, Karrasch, Stefan, Gieger, Christian, Deary, Ian J, Harris, Sarah E, Marten, Jonathan, Rudan, Igor, Enroth, Stefan, Gyllensten, Ulf, Kerr, Shona M, Polasek, Ozren, Kähönen, Mika, Surakka, Ida, Vitart, Veronique, Hayward, Caroline, Lehtimäki, Terho, Raitakari, Olli T, Evans, David M, Henderson, A John, Pennell, Craig E, Wang, Carol A, Sly, Peter D, Wan, Emily S, Busch, Robert, Hobbs, Brian D, Litonjua, Augusto A, Sparrow, David W, Gulsvik, Amund, Bakke, Per S, Crapo, James D, Beaty, Terri H, Hansel, Nadia N, Mathias, Rasika A, Ruczinski, Ingo, Barnes, Kathleen C, Bossé, Yohan, Joubert, Philippe, van den Berge, Maarten, Brandsma, Corry-Anke, Paré, Peter D, Sin, Don D, Nickle, David C, Hao, Ke, Gottesman, Omri, Dewey, Frederick E, Bruse, Shannon E, Carey, David J, Kirchner, H Lester, Jonsson, Stefan, Thorleifsson, Gudmar, Jonsdottir, Ingileif, Gislason, Thorarinn, Stefansson, Kari, Schurmann, Claudia, Nadkarni, Girish, Bottinger, Erwin P, Loos, Ruth JF, Walters, Robin G, Chen, Zhengming, Millwood, Iona Y, Vaucher, Julien, Kurmi, Om P, Li, Liming, Hansell, Anna L, Brightling, Chris, Zeggini, Eleftheria, Cho, Michael H, Silverman, Edwin K, Sayers, Ian, Trynka, Gosia, Morris, Andrew P, Strachan, David P, Hall, Ian P, Tobin, Martin D
Publicado 2017