Inhibition of Excessive Monoamine Oxidase A/B Activity Protects Against Stress-induced Neuronal Death in Huntington Disease

por Ooi, Jolene, Hayden, Michael R., Pouladi, Mahmoud A.
Publicado 2014

Generation of the Human Pluripotent Stem-Cell-Derived Astrocyte Model with Forebrain Identity

por Peteri, Ulla-Kaisa, Pitkonen, Juho, Utami, Kagistia Hana, Paavola, Jere, Roybon, Laurent, Pouladi, Mahmoud A., Castrén, Maija L.
Publicado 2021

Elevated de novo protein synthesis in FMRP-deficient human neurons and its correction by metformin treatment

por Utami, Kagistia Hana, Yusof, Nur Amirah Binte Mohammad, Kwa, Jing Eugene, Peteri, Ulla-Kaisa, Castrén, Maija L., Pouladi, Mahmoud A.
Publicado 2020

Widespread dysregulation of mRNA splicing implicates RNA processing in the development and progression of Huntington's disease

por Tano, Vincent, Utami, Kagistia Hana, Yusof, Nur Amirah Binte Mohammad, Bégin, Jocelyn, Tan, Willy Wei Li, Pouladi, Mahmoud A., Langley, Sarah R.
Publicado 2023

Histone modifications and p53 binding poise the p21 promoter for activation in human embryonic stem cells

por Itahana, Yoko, Zhang, Jinqiu, Göke, Jonathan, Vardy, Leah A., Han, Rachel, Iwamoto, Kozue, Cukuroglu, Engin, Robson, Paul, Pouladi, Mahmoud A., Colman, Alan, Itahana, Koji
Publicado 2016

Modeling Doxorubicin-Induced Cardiotoxicity in Human Pluripotent Stem Cell Derived-Cardiomyocytes

por Maillet, Agnes, Tan, Kim, Chai, Xiaoran, Sadananda, Singh N., Mehta, Ashish, Ooi, Jolene, Hayden, Michael R., Pouladi, Mahmoud A., Ghosh, Sujoy, Shim, Winston, Brunham, Liam R.
Publicado 2016

Novel mutation in HTRA1 in a family with diffuse white matter lesions and inflammatory features

por Ziaei, Amin, Xu, Xiaohong, Dehghani, Leila, Bonnard, Carine, Zellner, Andreas, Jin Ng, Alvin Yu, Tohari, Sumanty, Venkatesh, Byrappa, Haffner, Christof, Reversade, Bruno, Shaygannejad, Vahid, Pouladi, Mahmoud A.
Publicado 2019

Gene expression profiles complement the analysis of genomic modifiers of the clinical onset of Huntington disease

por Wright, Galen E B, Caron, Nicholas S, Ng, Bernard, Casal, Lorenzo, Casazza, William, Xu, Xiaohong, Ooi, Jolene, Pouladi, Mahmoud A, Mostafavi, Sara, Ross, Colin J D, Hayden, Michael R
Publicado 2020

Maturation Delay of Human GABAergic Neurogenesis in Fragile X Syndrome Pluripotent Stem Cells

por Zhang, Ai, Sokolova, Irina, Domissy, Alain, Davis, Joshua, Rao, Lee, Hana Utami, Kagistia, Wang, Yanling, Hagerman, Randi J, Pouladi, Mahmoud A, Sanna, Pietro, Boland, Michael J, Loring, Jeanne F
Publicado 2022

Early white matter pathology in the fornix of the limbic system in Huntington disease

por Gabery, Sanaz, Kwa, Jing Eugene, Cheong, Rachel Y., Baldo, Barbara, Ferrari Bardile, Costanza, Tan, Brendan, McLean, Catriona, Georgiou-Karistianis, Nellie, Poudel, Govinda R., Halliday, Glenda, Pouladi, Mahmoud A., Petersén, Åsa
Publicado 2021

Laquinimod rescues striatal, cortical and white matter pathology and results in modest behavioural improvements in the YAC128 model of Huntington disease

por Garcia-Miralles, Marta, Hong, Xin, Tan, Liang Juin, Caron, Nicholas S., Huang, Yihui, To, Xuan Vinh, Lin, Rachel Yanping, Franciosi, Sonia, Papapetropoulos, Spyros, Hayardeny, Liat, Hayden, Michael R., Chuang, Kai-Hsiang, Pouladi, Mahmoud A.
Publicado 2016

Evidences for Mutant Huntingtin Inducing Musculoskeletal and Brain Growth Impairments via Disturbing Testosterone Biosynthesis in Male Huntington Disease Animals

por Yu-Taeger, Libo, Novati, Arianna, Weber, Jonasz Jeremiasz, Singer-Mikosch, Elisabeth, Pabst, Ann-Sophie, Cheng, Fubo, Saft, Carsten, Koenig, Jennifer, Ellrichmann, Gisa, Heikkinen, Taneli, Pouladi, Mahmoud A., Riess, Olaf, Nguyen, Huu Phuc
Publicado 2022

A thiol probe for measuring unfolded protein load and proteostasis in cells

por Chen, Moore Z., Moily, Nagaraj S., Bridgford, Jessica L., Wood, Rebecca J., Radwan, Mona, Smith, Trevor A., Song, Zhegang, Tang, Ben Zhong, Tilley, Leann, Xu, Xiaohong, Reid, Gavin E., Pouladi, Mahmoud A., Hong, Yuning, Hatters, Danny M.
Publicado 2017

Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin

por Okamoto, Shu-ichi, Pouladi, Mahmoud A., Talantova, Maria, Yao, Dongdong, Xia, Peng, Ehrnhoefer, Dagmar E., Zaidi, Rameez, Clemente, Arjay, Kaul, Marcus, Graham, Rona K., Zhang, Dongxian, Chen, H.-S. Vincent, Tong, Gary, Hayden, Michael R., Lipton, Stuart A.
Publicado 2009

MUTANT HUNTINGTIN BINDS THE MITOCHONDRIAL FISSION GTPASE DRP1 AND INCREASES ITS ENZYMATIC ACTIVTY

por Song, Wenjun, Chen, Jin, Petrilli, Alejandra, Liot, Geraldine, Klinglmayr, Eva, Zhou, Yue, Poquiz, Patrick, Tjong, Jonathan, Pouladi, Mahmoud A., Hayden, Michael R., Masliah, Eliezer, Ellisman, Mark, Rouiller, Isabelle, Schwarzenbacher, Robert, Bossy, Blaise, Perkins, Guy, Bossy-Wetzel, Ella
Publicado 2011

Reversal of Phenotypic Abnormalities by CRISPR/Cas9-Mediated Gene Correction in Huntington Disease Patient-Derived Induced Pluripotent Stem Cells

por Xu, Xiaohong, Tay, Yilin, Sim, Bernice, Yoon, Su-In, Huang, Yihui, Ooi, Jolene, Utami, Kagistia Hana, Ziaei, Amin, Ng, Bryan, Radulescu, Carola, Low, Donovan, Ng, Alvin Yu Jin, Loh, Marie, Venkatesh, Byrappa, Ginhoux, Florent, Augustine, George J., Pouladi, Mahmoud A.
Publicado 2017

Structural and molecular myelination deficits occur prior to neuronal loss in the YAC128 and BACHD models of Huntington disease

por Teo, Roy Tang Yi, Hong, Xin, Yu-Taeger, Libo, Huang, Yihui, Tan, Liang Juin, Xie, Yuanyun, To, Xuan Vinh, Guo, Ling, Rajendran, Reshmi, Novati, Arianna, Calaminus, Carsten, Riess, Olaf, Hayden, Michael R., Nguyen, Huu P., Chuang, Kai-Hsiang, Pouladi, Mahmoud A.
Publicado 2016

A homozygous loss-of-function CAMK2A mutation causes growth delay, frequent seizures and severe intellectual disability

por Chia, Poh Hui, Zhong, Franklin Lei, Niwa, Shinsuke, Bonnard, Carine, Utami, Kagistia Hana, Zeng, Ruizhu, Lee, Hane, Eskin, Ascia, Nelson, Stanley F, Xie, William H, Al-Tawalbeh, Samah, El-Khateeb, Mohammad, Shboul, Mohammad, Pouladi, Mahmoud A, Al-Raqad, Mohammed, Reversade, Bruno
Publicado 2018

pS421 huntingtin modulates mitochondrial phenotypes and confers neuroprotection in an HD hiPSC model

por Xu, Xiaohong, Ng, Bryan, Sim, Bernice, Radulescu, Carola I., Yusof, Nur Amirah Binte Mohammad, Goh, Wah Ing, Lin, Shuping, Lim, John Soon Yew, Cha, Yoonjeong, Kusko, Rebecca, Kay, Chris, Ratovitski, Tamara, Ross, Christopher, Hayden, Michael R., Wright, Graham, Pouladi, Mahmoud A.
Publicado 2020

Pluripotent stem cell-derived models of neurological diseases reveal early transcriptional heterogeneity

por Sorek, Matan, Oweis, Walaa, Nissim-Rafinia, Malka, Maman, Moria, Simon, Shahar, Hession, Cynthia C., Adiconis, Xian, Simmons, Sean K., Sanjana, Neville E., Shi, Xi, Lu, Congyi, Pan, Jen Q., Xu, Xiaohong, Pouladi, Mahmoud A., Ellerby, Lisa M., Zhang, Feng, Levin, Joshua Z., Meshorer, Eran
Publicado 2021