Unraveling the mechanisms of intrinsic drug resistance in Mycobacterium tuberculosis

por Poulton, Nicholas C., Rock, Jeremy M.
Publicado 2022

The essential M. tuberculosis Clp protease is functionally asymmetric in vivo

por d’Andrea, Felipe B., Poulton, Nicholas C., Froom, Ruby, Tam, Kayan, Campbell, Elizabeth A., Rock, Jeremy M.
Publicado 2022

Beyond antibiotic resistance: the whiB7 transcription factor coordinates an adaptive response to alanine starvation in mycobacteria

por Poulton, Nicholas C., DeJesus, Michael A., Munsamy-Govender, Vanisha, Roberts, Cameron G., Azadian, Zachary A., Bosch, Barbara, Lin, Karl Matthew, Li, Shuqi, Rock, Jeremy M.
Publicado 2023

Cyclic AMP is a critical mediator of intrinsic drug resistance and fatty acid metabolism in M. tuberculosis

por Wong, Andrew I, Beites, Tiago, Planck, Kyle A, Fieweger, Rachael A, Eckartt, Kathryn A, Li, Shuqi, Poulton, Nicholas C, VanderVen, Brian C, Rhee, Kyu Y, Schnappinger, Dirk, Ehrt, Sabine, Rock, Jeremy
Publicado 2023

Genome-wide gene expression tuning reveals diverse vulnerabilities of M. tuberculosis

por Bosch, Barbara, DeJesus, Michael A., Poulton, Nicholas C., Zhang, Wenzhu, Engelhart, Curtis A., Zaveri, Anisha, Lavalette, Sophie, Ruecker, Nadine, Trujillo, Carolina, Wallach, Joshua B., Li, Shuqi, Ehrt, Sabine, Chait, Brian T., Schnappinger, Dirk, Rock, Jeremy M.
Publicado 2021

CRISPRi chemical genetics and comparative genomics identify genes mediating drug potency in Mycobacterium tuberculosis

por Li, Shuqi, Poulton, Nicholas C., Chang, Jesseon S., Azadian, Zachary A., DeJesus, Michael A., Ruecker, Nadine, Zimmerman, Matthew D., Eckartt, Kathryn A., Bosch, Barbara, Engelhart, Curtis A., Sullivan, Daniel F., Gengenbacher, Martin, Dartois, Véronique A., Schnappinger, Dirk, Rock, Jeremy M.
Publicado 2022