Tipping the balance: intricate roles of the complement system in disease and therapy

por Pouw, Richard B., Ricklin, Daniel
Publicado 2021

Complement & disease: out of the shadow into the spotlight

por Ricklin, Daniel, Pouw, Richard B.
Publicado 2021

Self-Damage Caused by Dysregulation of the Complement Alternative Pathway: Relevance of the Factor H Protein Family

por Sánchez-Corral, Pilar, Pouw, Richard B., López-Trascasa, Margarita, Józsi, Mihály
Publicado 2018

Complement Factor H-Related Protein 4A Is the Dominant Circulating Splice Variant of CFHR4

por Pouw, Richard B., Brouwer, Mieke C., van Beek, Anna E., Józsi, Mihály, Wouters, Diana, Kuijpers, Taco W.
Publicado 2018

High Complement Factor H-Related (FHR)-3 Levels Are Associated With the Atypical Hemolytic-Uremic Syndrome-Risk Allele CFHR3*B

por Pouw, Richard B., Gómez Delgado, Irene, López Lera, Alberto, Rodríguez de Córdoba, Santiago, Wouters, Diana, Kuijpers, Taco W., Sánchez-Corral, Pilar
Publicado 2018

Corrigendum: High Complement Factor H-Related (FHR)-3 Levels Are Associated With the Atypical Hemolytic-Uremic Syndrome-Risk Allele CFHR3(*)B

por Pouw, Richard B., Gómez Delgado, Irene, López Lera, Alberto, Rodríguez de Córdoba, Santiago, Wouters, Diana, Kuijpers, Taco W., Sánchez-Corral, Pilar
Publicado 2020

Complement Factor H-Related Protein 3 Serum Levels Are Low Compared to Factor H and Mainly Determined by Gene Copy Number Variation in CFHR3

por Pouw, Richard B., Brouwer, Mieke C., Geissler, Judy, van Herpen, Laurens V., Zeerleder, Sacha S., Wuillemin, Walter A., Wouters, Diana, Kuijpers, Taco W.
Publicado 2016

Complement Regulator FHR-3 Is Elevated either Locally or Systemically in a Selection of Autoimmune Diseases

por Schäfer, Nicole, Grosche, Antje, Reinders, Joerg, Hauck, Stefanie M., Pouw, Richard B., Kuijpers, Taco W., Wouters, Diana, Ehrenstein, Boris, Enzmann, Volker, Zipfel, Peter F., Skerka, Christine, Pauly, Diana
Publicado 2016

Complement inhibition can decrease the haemostatic response in a microvascular bleeding model at multiple levels

por Golomingi, Murielle, Kohler, Jessie, Lamers, Christina, Pouw, Richard B., Ricklin, Daniel, Dobó, József, Gál, Péter, Pál, Gábor, Kiss, Bence, Dopler, Arthur, Schmidt, Christoph Q., Hardy, Elaissa Trybus, Lam, Wilbur, Schroeder, Verena
Publicado 2023

Factor H-Related (FHR)-1 and FHR-2 Form Homo- and Heterodimers, while FHR-5 Circulates Only As Homodimer in Human Plasma

por van Beek, Anna E., Pouw, Richard B., Brouwer, Mieke C., van Mierlo, Gerard, Geissler, Judy, Ooijevaar-de Heer, Pleuni, de Boer, Martin, van Leeuwen, Karin, Rispens, Theo, Wouters, Diana, Kuijpers, Taco W.
Publicado 2017

Complement factor H contributes to mortality in humans and mice with bacterial meningitis

por Kasanmoentalib, E. Soemirien, Valls Serón, Mercedes, Engelen-Lee, Joo Yeon, Tanck, Michael W., Pouw, Richard B., van Mierlo, Gerard, Wouters, Diana, Pickering, Matthew C., van der Ende, Arie, Kuijpers, Taco W., Brouwer, Matthijs C., van de Beek, Diederik
Publicado 2019

The contribution of the alternative pathway in complement activation on cell surfaces depends on the strength of classical pathway initiation

por de Boer, Esther CW, Thielen, Astrid JF, Langereis, Jeroen D, Kamp, Angela, Brouwer, Mieke C, Oskam, Nienke, Jongsma, Marlieke L, Baral, April J, Spaapen, Robbert M, Zeerleder, Sacha, Vidarsson, Gestur, Rispens, Theo, Wouters, Diana, Pouw, Richard B, Jongerius, Ilse
Publicado 2023

Low Levels of Factor H Family Proteins During Meningococcal Disease Indicate Systemic Processes Rather Than Specific Depletion by Neisseria meningitidis

por van Beek, Anna E., Pouw, Richard B., Wright, Victoria J., Sallah, Neneh, Inwald, David, Hoggart, Clive, Brouwer, Mieke C., Galassini, Rachel, Thomas, John, Calvo-Bado, Leo, Fink, Colin G., Jongerius, Ilse, Hibberd, Martin, Wouters, Diana, Levin, Michael, Kuijpers, Taco W.
Publicado 2022

No prominent role for complement C1-esterase inhibitor in Marfan syndrome mice

por Hibender, Stijntje, Li, Siyu, Postma, Alex V, Hoogeland, Myrthe E, Klaver, Denise, Pouw, Richard B, Niessen, Hans W, Driessen, Antoine HG, Koolbergen, David R, de Vries, Carlie JM, Baars, Marieke JH, Houweling, Arjan C, Krijnen, Paul A, de Waard, Vivian
Publicado 2022

Variation in CFHR3 determines susceptibility to meningococcal disease by controlling factor H concentrations

por Kumar, Vikrant, Pouw, Richard B., Autio, Matias I., Sagmeister, Manfred G., Phua, Zai Yang, Borghini, Lisa, Wright, Victoria J., Hoggart, Clive, Pan, Bangfen, Tan, Antson Kiat Yee, Binder, Alexander, Brouwer, Mieke C., Pinnock, Ellie, De Groot, Ronald, Hazelzet, Jan, Emonts, Marieke, Van Der Flier, Michiel, Reiter, Karl, Nöthen, Markus M., Hoffmann, Per, Schlapbach, Luregn J., Bellos, Evangelos, Anderson, Suzanne, Secka, Fatou, Martinón-Torres, Federico, Salas, Antonio, Fink, Colin, Carrol, Enitan D., Pollard, Andrew J., Coin, Lachlan J., Zenz, Werner, Wouters, Diana, Ang, Lay Teng, Hibberd, Martin L., Levin, Michael, Kuijpers, Taco W., Davila, Sonia
Publicado 2022