Biotherapeutic protein formulation variables influence protein integrity and can promote post-translational modifications as shown using chicken egg white lysozyme as a model syste...

por Gourbatsi, Evdoxia, Povey, Jane, Uddin, Shahid, Smales, C. Mark
Publicado 2015

(1)H NMR Spectroscopy Profiling of Metabolic Reprogramming of Chinese Hamster Ovary Cells upon a Temperature Shift during Culture

por Wagstaff, Jane L., Masterton, Rosalyn J., Povey, Jane F., Smales, C. Mark, Howard, Mark J.
Publicado 2013

Manipulation of mRNA translation elongation influences the fragmentation of a biotherapeutic Fc‐fusion protein produced in CHO cells

por Knight, Tanya J., Povey, Jane F., Vito, Davide, Mohindra, Atul, Jaques, Colin M., Smales, C. Mark
Publicado 2022

A cell culture platform for Cryptosporidium that enables long-term cultivation and new tools for the systematic investigation of its biology

por Miller, Christopher N., Jossé, Lyne, Brown, Ian, Blakeman, Ben, Povey, Jane, Yiangou, Lyto, Price, Mark, Cinatl, Jindrich, Xue, Wei-Feng, Michaelis, Martin, Tsaousis, Anastasios D.
Publicado 2018

Intact-Cell MALDI-ToF Mass Spectrometry for the Authentication of Drug-Adapted Cancer Cell Lines

por Povey, Jane F., Saintas, Emily, Aderemi, Adewale V., Rothweiler, Florian, Zehner, Richard, Dirks, Wilhelm G., Cinatl, Jindrich, Racher, Andrew J., Wass, Mark N., Smales, C. Mark, Michaelis, Martin
Publicado 2019

Engineering of Chinese hamster ovary cell lipid metabolism results in an expanded ER and enhanced recombinant biotherapeutic protein production

por Budge, James D., Knight, Tanya J., Povey, Jane, Roobol, Joanne, Brown, Ian R., Singh, Gurdeep, Dean, Andrew, Turner, Sarah, Jaques, Colin M., Young, Robert J., Racher, Andrew J., Smales, C. Mark
Publicado 2020

Data for engineering lipid metabolism of Chinese hamster ovary (CHO) cells for enhanced recombinant protein production

por Budge, James D., Knight, Tanya J., Povey, Jane, Roobol, Joanne, Brown, Ian R., Singh, Gurdeep, Dean, Andrew, Turner, Sarah, Jaques, Colin M., Young, Robert J., Racher, Andrew J., Smales, C Mark
Publicado 2020

A proline metabolism selection system and its application to the engineering of lipid biosynthesis in Chinese hamster ovary cells

por Budge, James D., Roobol, Joanne, Singh, Gurdeep, Mozzanino, Théo, Knight, Tanya J., Povey, Jane, Dean, Andrew, Turner, Sarah J., Jaques, Colin M., Young, Robert J., Racher, Andrew J., Smales, C. Mark
Publicado 2021