Processing of Damaged DNA Ends for Double-Strand Break Repair in Mammalian Cells

por Povirk, Lawrence F.
Publicado 2012

Tyrosyl–DNA phosphodiesterases: rescuing the genome from the risks of relaxation

por Kawale, Ajinkya S, Povirk, Lawrence F
Publicado 2018

ATM-independent, high-fidelity nonhomologous end joining predominates in human embryonic stem cells

por Adams, Bret R., Hawkins, Amy J., Povirk, Lawrence F., Valerie, Kristoffer
Publicado 2010

Restoration of G1 chemo/radioresistance and double-strand-break repair proficiency by wild-type but not endonuclease-deficient Artemis

por Mohapatra, Susovan, Kawahara, Misako, Khan, Imran S., Yannone, Steven M., Povirk, Lawrence F.
Publicado 2011

Tracking the processing of damaged DNA double-strand break ends by ligation-mediated PCR: increased persistence of 3′-phosphoglycolate termini in SCAN1 cells

por Akopiants, Konstantin, Mohapatra, Susovan, Menon, Vijay, Zhou, Tong, Valerie, Kristoffer, Povirk, Lawrence F.
Publicado 2014

Loop 1 modulates the fidelity of DNA polymerase λ

por Bebenek, Katarzyna, Garcia-Diaz, Miguel, Zhou, Rui-Zhe, Povirk, Lawrence F., Kunkel, Thomas A.
Publicado 2010

Phosphorylation in the serine/threonine 2609–2647 cluster promotes but is not essential for DNA-dependent protein kinase-mediated nonhomologous end joining in human whole-cell extr...

por Povirk, Lawrence F., Zhou, Rui-Zhe, Ramsden, Dale A., Lees-Miller, Susan P., Valerie, Kristoffer
Publicado 2007

Coordinate 5′ and 3′ endonucleolytic trimming of terminally blocked blunt DNA double-strand break ends by Artemis nuclease and DNA-dependent protein kinase

por Yannone, Steven M., Khan, Imran S., Zhou, Rui-Zhe, Zhou, Tong, Valerie, Kristoffer, Povirk, Lawrence F.
Publicado 2008

Deficiency in 3′-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1)

por Zhou, Tong, Lee, Jae Wan, Tatavarthi, Haritha, Lupski, James R., Valerie, Kristoffer, Povirk, Lawrence F.
Publicado 2005

Tolerance for 8-oxoguanine but not thymine glycol in alignment-based gap filling of partially complementary double-strand break ends by DNA polymerase λ in human nuclear extracts

por Zhou, Rui-Zhe, Blanco, Luis, Garcia-Diaz, Miguel, Bebenek, Katarzyna, Kunkel, Thomas A., Povirk, Lawrence F.
Publicado 2008

The Mre11/Rad50/Nbs1 complex functions in resection-based DNA end joining in Xenopus laevis

por Taylor, Elaine M., Cecillon, Sophie M., Bonis, Antonio, Chapman, J. Ross, Povirk, Lawrence F., Lindsay, Howard D.
Publicado 2010

Nucleolar Targeting by Platinum: p53-Independent Apoptosis Follows rRNA Inhibition, Cell-Cycle Arrest, and DNA Compaction

por Peterson, Erica J., Menon, Vijay R., Gatti, Laura, Kipping, Ralph, Dewasinghe, Dilhara, Perego, Paola, Povirk, Lawrence F., Farrell, Nicholas P.
Publicado 2014

TDP1 suppresses mis-joining of radiomimetic DNA double-strand breaks and cooperates with Artemis to promote optimal nonhomologous end joining

por Kawale, Ajinkya S, Akopiants, Konstantin, Valerie, Kristoffer, Ruis, Brian, Hendrickson, Eric A, Huang, Shar-yin N, Pommier, Yves, Povirk, Lawrence F
Publicado 2018

Mutations in the BRCT binding site of BRCA1 result in hyper-recombination

por Dever, Seth M., Golding, Sarah E., Rosenberg, Elizabeth, Adams, Bret R., Idowu, Michael O., Quillin, John M., Valerie, Nicholas, Xu, Bo, Povirk, Lawrence F., Valerie, Kristoffer
Publicado 2011

Requirement for XLF/Cernunnos in alignment-based gap filling by DNA polymerases λ and μ for nonhomologous end joining in human whole-cell extracts

por Akopiants, Konstantin, Zhou, Rui-Zhe, Mohapatra, Susovan, Valerie, Kristoffer, Lees-Miller, Susan P., Lee, Kyung-Jong, Chen, David J., Revy, Patrick, de Villartay, Jean-Pierre, Povirk, Lawrence F.
Publicado 2009

ATM phosphorylates PP2A subunit A resulting in nuclear export and spatiotemporal regulation of the DNA damage response

por Sule, Amrita, Golding, Sarah E., Ahmad, Syed F., Watson, James, Ahmed, Mostafa H., Kellogg, Glen E., Bernas, Tytus, Koebley, Sean, Reed, Jason C., Povirk, Lawrence F., Valerie, Kristoffer
Publicado 2022

Mutation of the BRCA1 SQ-cluster results in aberrant mitosis, reduced homologous recombination, and a compensatory increase in non-homologous end joining

por Beckta, Jason M., Dever, Seth M., Gnawali, Nisha, Khalil, Ashraf, Sule, Amrita, Golding, Sarah E., Rosenberg, Elizabeth, Narayanan, Aarthi, Kehn-Hall, Kylene, Xu, Bo, Povirk, Lawrence F., Valerie, Kristoffer
Publicado 2015

Correction: Mutation of the BRCA1 SQ-cluster results in aberrant mitosis, reduced homologous recombination, and a compensatory increase in non-homologous end joining

por Beckta, Jason M., Dever, Seth M., Gnawali, Nisha, Khalil, Ashraf, Sule, Amrita, Golding, Sarah E., Rosenberg, Elizabeth, Narayanan, Aarthi, Kehn-Hall, Kylene, Xu, Bo, Povirk, Lawrence F., Valerie, Kristoffer
Publicado 2016