Evaluating and comparing immunostaining and computational methods for spatial profiling of drug response in patient-derived explants

por Miles, Gareth J, Powley, Ian, Mohammed, Seid, Howells, Lynne, Pringle, J. Howard, Hammonds, Tim, MacFarlane, Marion, Pritchard, Catrin
Publicado 2021

Patient-derived explants (PDEs) as a powerful preclinical platform for anti-cancer drug and biomarker discovery

por Powley, Ian R., Patel, Meeta, Miles, Gareth, Pringle, Howard, Howells, Lynne, Thomas, Anne, Kettleborough, Catherine, Bryans, Justin, Hammonds, Tim, MacFarlane, Marion, Pritchard, Catrin
Publicado 2020

Co-operative and Hierarchical Binding of c-FLIP and Caspase-8: A Unified Model Defines How c-FLIP Isoforms Differentially Control Cell Fate

por Hughes, Michelle A., Powley, Ian R., Jukes-Jones, Rebekah, Horn, Sebastian, Feoktistova, Maria, Fairall, Louise, Schwabe, John W.R., Leverkus, Martin, Cain, Kelvin, MacFarlane, Marion
Publicado 2016

Cryo-EM structural analysis of FADD:Caspase-8 complexes defines the catalytic dimer architecture for co-ordinated control of cell fate

por Fox, Joanna L., Hughes, Michelle A., Meng, Xin, Sarnowska, Nikola A., Powley, Ian R., Jukes-Jones, Rebekah, Dinsdale, David, Ragan, Timothy J., Fairall, Louise, Schwabe, John W. R., Morone, Nobuhiro, Cain, Kelvin, MacFarlane, Marion
Publicado 2021

Analysis of Prostate Cancer Tumor Microenvironment Identifies Reduced Stromal CD4 Effector T-cell Infiltration in Tumors with Pelvic Nodal Metastasis

por Ntala, Chara, Salji, Mark, Salmond, Jonathan, Officer, Leah, Teodosio, Ana Vieira, Blomme, Arnaud, McGhee, Ewan J., Powley, Ian, Ahmad, Imran, Kruithof-de Julio, Marianna, Thalmann, George, Roberts, Ed, Goodyear, Carl S., Jamaspishvili, Tamara, Berman, David M., Carlin, Leo M., Le Quesne, John, Leung, Hing Y.
Publicado 2021

Long-Fiber Carbon Nanotubes Replicate Asbestos-Induced Mesothelioma with Disruption of the Tumor Suppressor Gene Cdkn2a (Ink4a/Arf)

por Chernova, Tatyana, Murphy, Fiona A., Galavotti, Sara, Sun, Xiao-Ming, Powley, Ian R., Grosso, Stefano, Schinwald, Anja, Zacarias-Cabeza, Joaquin, Dudek, Kate M., Dinsdale, David, Le Quesne, John, Bennett, Jonathan, Nakas, Apostolos, Greaves, Peter, Poland, Craig A., Donaldson, Ken, Bushell, Martin, Willis, Anne E., MacFarlane, Marion
Publicado 2017