Extracellular loops 1 and 3 and their associated transmembrane regions of the calcitonin receptor-like receptor are needed for CGRP receptor function

por Barwell, James, Conner, Alex, Poyner, David R.
Publicado 2011

Mapping interaction sites within the N-terminus of the calcitonin gene-related peptide receptor; the role of residues 23–60 of the calcitonin receptor-like receptor

por Barwell, James, Miller, Philip S., Donnelly, Dan, Poyner, David R.
Publicado 2010

Signalling by CGRP and Adrenomedullin in the Cerebellum and Other Systems

por Poyner, David, Cater, Heather, Hartell, Nick, Conner, Alex, Hay, Debbie, Howitt, Steve, Smith, Dave
Publicado 2001

Determining the Effects of Differential Expression of GRKs and β-arrestins on CLR-RAMP Agonist Bias

por Pearce, Abigail, Redfern-Nichols, Theo, Harris, Matthew, Poyner, David R., Wigglesworth, Mark, Ladds, Graham
Publicado 2022

Non-peptidic antagonists of the CGRP receptor, BIBN4096BS and MK-0974, interact with the calcitonin receptor-like receptor via methionine-42 and RAMP1 via tryptophan-74

por Miller, Philip S., Barwell, James, Poyner, David R., Wigglesworth, Mark J., Garland, Stephen L., Donnelly, Dan
Publicado 2010

Functional recombinant protein is present in the pre-induction phases of Pichia pastoris cultures when grown in bioreactors, but not shake-flasks

por Bawa, Zharain, Routledge, Sarah J, Jamshad, Mohammed, Clare, Michelle, Sarkar, Debasmita, Dickerson, Ian, Ganzlin, Markus, Poyner, David R, Bill, Roslyn M
Publicado 2014

Structure–activity relationships of the N-terminus of calcitonin gene-related peptide: key roles of alanine-5 and threonine-6 in receptor activation

por Hay, Debbie L, Harris, Paul WR, Kowalczyk, Renata, Brimble, Margaret A, Rathbone, Dan L, Barwell, James, Conner, Alex C, Poyner, David R
Publicado 2014

An allosteric role for receptor activity-modifying proteins in defining GPCR pharmacology

por J Gingell, Joseph, Simms, John, Barwell, James, Poyner, David R, Watkins, Harriet A, Pioszak, Augen A, Sexton, Patrick M, Hay, Debbie L
Publicado 2016

An allosteric role for receptor activity-modifying proteins in defining GPCR pharmacology

por Gingell, Joseph J, Simms, John, Barwell, James, Poyner, David R, Watkins, Harriet A, Pioszak, Augen A, Sexton, Patrick M, Hay, Debbie L
Publicado 2016

Altering the ribosomal subunit ratio in yeast maximizes recombinant protein yield

por Bonander, Nicklas, Darby, Richard AJ, Grgic, Ljuban, Bora, Nagamani, Wen, Jikai, Brogna, Saverio, Poyner, David R, O'Neill, Michael AA, Bill, Roslyn M
Publicado 2009

Receptor component protein, an endogenous allosteric modulator of family B G protein coupled receptors

por Routledge, Sarah J., Simms, John, Clark, Ashley, Yeung, Ho Yan, Wigglesworth, Mark J., Dickerson, Ian M., Kitchen, Philip, Ladds, Graham, Poyner, David R.
Publicado 2020

Functional solubilization of the β(2)-adrenoceptor using diisobutylene maleic acid

por Harwood, Clare.R., Sykes, David A., Hoare, Bradley L., Heydenreich, Franziska M., Uddin, Romez, Poyner, David R., Briddon, Stephen J., Veprintsev, D.B.
Publicado 2021

The Role of ICL1 and H8 in Class B1 GPCRs; Implications for Receptor Activation

por Winfield, Ian, Barkan, Kerry, Routledge, Sarah, Robertson, Nathan J., Harris, Matthew, Jazayeri, Ali, Simms, John, Reynolds, Christopher A., Poyner, David R., Ladds, Graham
Publicado 2022

Similarity between class A and class B G-protein-coupled receptors exemplified through calcitonin gene-related peptide receptor modelling and mutagenesis studies

por Vohra, Shabana, Taddese, Bruck, Conner, Alex C., Poyner, David R., Hay, Debbie L., Barwell, James, Reeves, Philip J., Upton, Graham J. G., Reynolds, Christopher A.
Publicado 2013

Receptor activity-modifying protein dependent and independent activation mechanisms in the coupling of calcitonin gene-related peptide and adrenomedullin receptors to Gs

por Woolley, Michael J., Reynolds, Christopher A., Simms, John, Walker, Christopher S., Mobarec, Juan Carlos, Garelja, Michael L., Conner, Alex C., Poyner, David R., Hay, Debbie L.
Publicado 2017

CGRP, adrenomedullin and adrenomedullin 2 display endogenous GPCR agonist bias in primary human cardiovascular cells

por Clark, Ashley J., Mullooly, Niamh, Safitri, Dewi, Harris, Matthew, de Vries, Tessa, MaassenVanDenBrink, Antoinette, Poyner, David R., Gianni, Davide, Wigglesworth, Mark, Ladds, Graham
Publicado 2021

The role of ECL2 in CGRP receptor activation: a combined modelling and experimental approach

por Woolley, Michael. J., Watkins, Harriet A., Taddese, Bruck, Karakullukcu, Z. Gamze, Barwell, James, Smith, Kevin J., Hay, Debbie L., Poyner, David R., Reynolds, Christopher A., Conner, Alex C.
Publicado 2013

Ligand-induced conformational changes in a SMALP-encapsulated GPCR.

por Routledge, Sarah J., Jamshad, Mohammed, Little, Haydn A., Lin, Yu-Pin, Simms, John, Thakker, Alpesh, Spickett, Corinne M., Bill, Roslyn M., Dafforn, Tim R., Poyner, David R., Wheatley, Mark
Publicado 2020

Differences in SMA-like polymer architecture dictate the conformational changes exhibited by the membrane protein rhodopsin encapsulated in lipid nano-particles

por Grime, Rachael L., Logan, Richard T., Nestorow, Stephanie A., Sridhar, Pooja, Edwards, Patricia C., Tate, Christopher G., Klumperman, Bert, Dafforn, Tim R., Poyner, David R., Reeves, Philip J., Wheatley, Mark
Publicado 2021

G-protein coupled receptor solubilization and purification for biophysical analysis and functional studies, in the total absence of detergent

por Jamshad, Mohammed, Charlton, Jack, Lin, Yu-Pin, Routledge, Sarah J., Bawa, Zharain, Knowles, Timothy J., Overduin, Michael, Dekker, Niek, Dafforn, Tim R., Bill, Roslyn M., Poyner, David R., Wheatley, Mark
Publicado 2015