CTGF-mediated autophagy-senescence transition in tumor stroma promotes anabolic tumor growth and metastasis

por Prabhu, Varun V., Warfel, Noel A., El-Deiry, Wafik S.
Publicado 2012

MODL-06. PRECLINICAL EFFICACY OF THE IMIPRIDONE ONC-206 AGAINST MEDULLOBLASTOMA

por Malhotra, Anshu, Liu, Jingbo, Zhang, Hongying, Ma, Minhui, Vega, Jose Velazquez, Schniederjan, Matthew, Prabhu, Varun, Allen, Joshua, MacDonald, Tobey
Publicado 2020

HGG-42. PEDIATRIC H3K27M MUTANT DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) SHOWS ROBUST RESPONSE TO IMIPRIDONE BASED COMBINATION THERAPY

por Borsuk, Robyn, Zhou, Lanlan, Chang, Wen-i, Zhang, Yiqun, Prabhu, Varun, Allen, Joshua, Tapinos, Nikos, Lulla, Rishi, El-Deiry, Wafik
Publicado 2021

Phase II Study of ONC201 in Neuroendocrine Tumors including Pheochromocytoma-Paraganglioma and Desmoplastic Small Round Cell Tumor

por Anderson, Peter M., Trucco, Matteo M., Tarapore, Rohinton S., Zahler, Stacey, Thomas, Stefanie, Gortz, Janette, Mian, Omar, Stoignew, Martin, Prabhu, Varun, Morrow, Sara, Allen, Joshua E.
Publicado 2022

ONC201/TIC10 Is Empowered by 2-Deoxyglucose and Causes Metabolic Reprogramming in Medulloblastoma Cells in Vitro Independent of C-Myc Expression

por Dwucet, Annika, Pruss, Maximilian, Cao, Qiyu, Tanriover, Mine, Prabhu, Varun V., Allen, Joshua E., Peraud, Aurelia, Westhoff, Mike-Andrew, Siegelin, Markus D., Wirtz, Christian Rainer, Karpel-Massler, Georg
Publicado 2021

Combination of ONC201 and TLY012 induces selective, synergistic apoptosis in vitro and significantly delays PDAC xenograft growth in vivo

por Jhaveri, Aakash V., Zhou, Lanlan, Ralff, Marie D., Lee, Young S., Navaraj, Arunasalam, Carneiro, Benedito A., Safran, Howard, Prabhu, Varun V., Ross, Eric A., Lee, Seulki, El-Deiry, Wafik S.
Publicado 2021

Induction of Synthetic Lethality by Activation of Mitochondrial ClpP and Inhibition of HDAC1/2 in Glioblastoma

por Nguyen, Trang T.T., Shang, Enyuan, Schiffgens, Salveena, Torrini, Consuelo, Shu, Chang, Akman, Hasan Orhan, Prabhu, Varun V., Allen, Joshua E., Westhoff, Mike-Andrew, Karpel-Massler, Georg, Siegelin, Markus D.
Publicado 2022

Anti-pancreatic cancer activity of ONC212 involves the unfolded protein response (UPR) and is reduced by IGF1-R and GRP78/BIP

por Lev, Avital, Lulla, Amriti R., Wagner, Jessica, Ralff, Marie D., Kiehl, Joshua B., Zhou, Yan, Benes, Cyril H., Prabhu, Varun V., Oster, Wolfgang, Astsaturov, Igor, Dicker, David T., El-Deiry, Wafik S.
Publicado 2017

ONC206, an Imipridone Derivative, Induces Cell Death Through Activation of the Integrated Stress Response in Serous Endometrial Cancer In Vitro

por Zhang, Yingao, Huang, Yu, Yin, Yajie, Fan, Yali, Sun, Wenchuan, Zhao, Xiaoling, Tucker, Katherine, Staley, Allison, Paraghamian, Sarah, Hawkins, Gabrielle, Prabhu, Varun, Allen, Joshua E., Zhou, Chunxiao, Bae-Jump, Victoria
Publicado 2020

A novel dopamine receptor D2 antagonist (ONC206) potentiates the effects of olaparib in endometrial cancer

por Paraghamian, Sarah E., Qiu, Jianqing, Hawkins, Gabrielle M., Zhao, Ziyi, Sun, Wenchuan, Fan, Yali, Zhang, Xin, Suo, Hongyan, Hao, Tianran, Prabhu, Varun Vijay, Allen, Joshua E., Zhou, Chunxiao, Bae-Jump, Victoria
Publicado 2023

Anti-Tumor and Anti-Invasive Effects of ONC201 on Ovarian Cancer Cells and a Transgenic Mouse Model of Serous Ovarian Cancer

por Fan, Yali, Wang, Jiandong, Fang, Ziwei, Pierce, Stuart R., West, Lindsay, Staley, Allison, Tucker, Katherine, Yin, Yajie, Sun, Wenchuan, Kong, Weimin, Prabhu, Varun, Allen, Joshua E., Zhou, Chunxiao, Bae-Jump, Victoria L.
Publicado 2022

Imipridone ONC212 activates orphan G protein-coupled receptor GPR132 and integrated stress response in acute myeloid leukemia

por Nii, Takenobu, Prabhu, Varun V., Ruvolo, Vivian, Madhukar, Neel, Zhao, Ran, Mu, Hong, Heese, Lauren, Nishida, Yuki, Kojima, Kensuke, Garnett, Mathew J., McDermott, Ultan, Benes, Cyril H., Charter, Neil, Deacon, Sean, Elemento, Olivier, Allen, Joshua E., Oster, Wolfgang, Stogniew, Martin, Ishizawa, Jo, Andreeff, Michael
Publicado 2019

Targeting dopamine receptor D2 as a novel therapeutic strategy in endometrial cancer

por Pierce, Stuart R., Fang, Ziwei, Yin, Yajie, West, Lindsay, Asher, Majdouline, Hao, Tianran, Zhang, Xin, Tucker, Katherine, Staley, Allison, Fan, Yali, Sun, Wenchuan, Moore, Dominic T., Xu, Chang, Tsai, Yi-Hsuan, Parker, Joel, Prabhu, Varun Vijay, Allen, Joshua E., Lee, Douglas, Zhou, Chunxiao, Bae-Jump, Victoria
Publicado 2021

Cancer stem cell-related gene expression as a potential biomarker of response for first-in-class imipridone ONC201 in solid tumors

por Prabhu, Varun V., Lulla, Amriti R., Madhukar, Neel S., Ralff, Marie D., Zhao, Dan, Kline, Christina Leah B., Van den Heuvel, A. Pieter J., Lev, Avital, Garnett, Mathew J., McDermott, Ultan, Benes, Cyril H., Batchelor, Tracy T., Chi, Andrew S., Elemento, Olivier, Allen, Joshua E., El-Deiry, Wafik S.
Publicado 2017

ONC201 and imipridones: Anti-cancer compounds with clinical efficacy

por Prabhu, Varun Vijay, Morrow, Sara, Rahman Kawakibi, Abed, Zhou, Lanlan, Ralff, Marie, Ray, Jocelyn, Jhaveri, Aakash, Ferrarini, Isacco, Lee, Young, Parker, Cassandra, Zhang, Yiqun, Borsuk, Robyn, Chang, Wen-I, Honeyman, Joshua N., Tavora, Fabio, Carneiro, Benedito, Raufi, Alexander, Huntington, Kelsey, Carlsen, Lindsey, Louie, Anna, Safran, Howard, Seyhan, Attila A., Tarapore, Rohinton S., Schalop, Lee, Stogniew, Martin, Allen, Joshua E., Oster, Wolfgang, El-Deiry, Wafik S.
Publicado 2020

Discovery and clinical introduction of first-in-class imipridone ONC201

por Allen, Joshua E., Kline, C. Leah B., Prabhu, Varun V., Wagner, Jessica, Ishizawa, Jo, Madhukar, Neel, Lev, Avital, Baumeister, Marie, Zhou, Lanlan, Lulla, Amriti, Stogniew, Martin, Schalop, Lee, Benes, Cyril, Kaufman, Howard L., Pottorf, Richard S., Nallaganchu, B. Rao, Olson, Gary L., Al-Mulla, Fahd, Duvic, Madeleine, Wu, Gen Sheng, Dicker, David T., Talekar, Mala K., Lim, Bora, Elemento, Olivier, Oster, Wolfgang, Bertino, Joseph, Flaherty, Keith, Wang, Michael L., Borthakur, Gautam, Andreeff, Michael, Stein, Mark, El-Deiry, Wafik S.
Publicado 2016

Correction: Discovery and clinical introduction of first-in-class imipridone ONC201

por Allen, Joshua E., Kline, C. Leah B., Prabhu, Varun V., Wagner, Jessica, Ishizawa, Jo, Madhukar, Neel, Lev, Avital, Baumeister, Marie, Zhou, Lanlan, Lulla, Amriti, Stogniew, Martin, Schalop, Lee, Benes, Cyril, Kaufman, Howard L., Pottorf, Richard S., Nallaganchu, B. Rao, Olson, Gary L., Al-Mulla, Fahd, Duvic, Madeleine, Wu, Gen Sheng, Dicker, David T., Talekar, Mala K., Lim, Bora, Elemento, Olivier, Oster, Wolfgang, Bertino, Joseph, Flaherty, Keith, Wang, Michael L., Borthakur, Gautam, Andreeff, Michael, Stein, Mark, El-Deiry, Wafik S.
Publicado 2021

Safety and enhanced immunostimulatory activity of the DRD2 antagonist ONC201 in advanced solid tumor patients with weekly oral administration

por Stein, Mark N., Malhotra, Jyoti, Tarapore, Rohinton S., Malhotra, Usha, Silk, Ann W., Chan, Nancy, Rodriguez, Lorna, Aisner, Joseph, Aiken, Robert D., Mayer, Tina, Haffty, Bruce G., Newman, Jenna H., Aspromonte, Salvatore M., Bommareddy, Praveen K., Estupinian, Ricardo, Chesson, Charles B., Sadimin, Evita T., Li, Shengguo, Medina, Daniel J., Saunders, Tracie, Frankel, Melissa, Kareddula, Aparna, Damare, Sherrie, Wesolowsky, Elayne, Gabel, Christian, El-Deiry, Wafik S., Prabhu, Varun V., Allen, Joshua E., Stogniew, Martin, Oster, Wolfgang, Bertino, Joseph R., Libutti, Steven K., Mehnert, Janice M., Zloza, Andrew
Publicado 2019