Axonal degeneration in an Alzheimer mouse model is PS1 gene dose dependent and linked to intraneuronal Aβ accumulation

por Christensen, Ditte Z., Huettenrauch, Melanie, Mitkovski, Miso, Pradier, Laurent, Wirths, Oliver
Publicado 2014

Neural Differentiation of Embryonic Stem Cells In Vitro: A Road Map to Neurogenesis in the Embryo

por Abranches, Elsa, Silva, Margarida, Pradier, Laurent, Schulz, Herbert, Hummel, Oliver, Henrique, Domingos, Bekman, Evguenia
Publicado 2009

Participating in innovative medicines initiative funded neurodegenerative disorder projects—An impact analysis conducted as part of the NEURONET project

por Hawksworth, Claire, Salih, Fatima, Cresswell, Katharine, Steukers, Lennert, Diaz, Carlos, Killin, Lewis, Pradier, Laurent, Bradshaw, Angela, Dawoud, Dalia
Publicado 2023

Neuroprotective role of PKR in a model of neurodegeneration due to mild impairment of oxidative metabolism

por Mouton-Liger, François, Rebillat, Anne-Sophie, Gourmaud, Sarah, Leguen, Audrey, Paquet, Claire, Pradier, Laurent, Rooney, Thomas, Hugon, Jacques
Publicado 2013

Reporter cell assay for human CD33 validated by specific antibodies and human iPSC-derived microglia

por Wißfeld, Jannis, Mathews, Mona, Mossad, Omar, Picardi, Paola, Cinti, Alessandro, Redaelli, Loredana, Pradier, Laurent, Brüstle, Oliver, Neumann, Harald
Publicado 2021

In Vivo Detection of Amyloid Plaques by Gadolinium-Stained MRI Can Be Used to Demonstrate the Efficacy of an Anti-amyloid Immunotherapy

por Santin, Mathieu D., Vandenberghe, Michel E., Herard, Anne-Sophie, Pradier, Laurent, Cohen, Caroline, Debeir, Thomas, Delzescaux, Thierry, Rooney, Thomas, Dhenain, Marc
Publicado 2016

The Innovative Medicines Initiative neurodegeneration portfolio: From individual projects to collaborative networks

por O'Rourke, Diana, Coll-Padrós, Nina, Bradshaw, Angela, Killin, Lewis, Pradier, Laurent, Georges, Jean, Dawoud, Dalia M., Steukers, Lennert, Diaz, Carlos
Publicado 2022

LRP1 Has a Predominant Role in Production over Clearance of Aβ in a Mouse Model of Alzheimer’s Disease

por Van Gool, Bart, Storck, Steffen E., Reekmans, Sara M., Lechat, Benoit, Gordts, Philip L. S. M., Pradier, Laurent, Pietrzik, Claus U., Roebroek, Anton J. M.
Publicado 2019

A calcium-sensitive antibody isolates soluble amyloid-β aggregates and fibrils from Alzheimer’s disease brain

por Stern, Andrew M, Liu, Lei, Jin, Shanxue, Liu, Wen, Meunier, Angela L, Ericsson, Maria, Miller, Michael B, Batson, Megan, Sun, Tingwan, Kathuria, Sagar, Reczek, David, Pradier, Laurent, Selkoe, Dennis J
Publicado 2022

Learnings about Aβ from human brain recommend the use of a live-neuron bioassay for the discovery of next generation Alzheimer’s disease immunotherapeutics

por Wang, Zemin, Jin, Ming, Hong, Wei, Liu, Wen, Reczek, David, Lagomarsino, Valentina N., Hu, Yuan, Weeden, Tim, Frosch, Matthew P., Young-Pearse, Tracy L., Pradier, Laurent, Selkoe, Dennis, Walsh, Dominic M.
Publicado 2023

SAR110894, a potent histamine H3-receptor antagonist, displays disease-modifying activity in a transgenic mouse model of tauopathy

por Delay-Goyet, Philippe, Blanchard, Véronique, Schussler, Nathalie, Lopez-Grancha, Mati, Ménager, Jean, Mary, Véronique, Sultan, Eric, Buzy, Armelle, Guillemot, Jean-Claude, Stemmelin, Jeanne, Bertrand, Philippe, Rooney, Thomas, Pradier, Laurent, Barnéoud, Pascal
Publicado 2016

Gene delivery of a modified antibody to Aβ reduces progression of murine Alzheimer’s disease

por Elmer, Bradford M., Swanson, Kurt A., Bangari, Dinesh S., Piepenhagen, Peter A., Roberts, Errin, Taksir, Tatyana, Guo, Lei, Obinu, Maria-Carmen, Barneoud, Pascal, Ryan, Susan, Zhang, Bailin, Pradier, Laurent, Yang, Zhi-Yong, Nabel, Gary J.
Publicado 2019

High-throughput 3D whole-brain quantitative histopathology in rodents

por Vandenberghe, Michel E., Hérard, Anne-Sophie, Souedet, Nicolas, Sadouni, Elmahdi, Santin, Mathieu D., Briet, Dominique, Carré, Denis, Schulz, Jocelyne, Hantraye, Philippe, Chabrier, Pierre-Etienne, Rooney, Thomas, Debeir, Thomas, Blanchard, Véronique, Pradier, Laurent, Dhenain, Marc, Delzescaux, Thierry
Publicado 2016

Novel potent liposome agonists of triggering receptor expressed on myeloid cells 2 phenocopy antibody treatment in cells

por Boudesco, Christophe, Nonneman, Annelies, Cinti, Alessandro, Picardi, Paola, Redaelli, Loredana, Swijsen, Sofie, Roewe, Julian, Reinhardt, Peter, Ibach, Melanie, Walter, Jochen, Pocock, Jennifer M., Ren, Yi, Driguez, Pierre‐Alexandre, Dargazanli, Gihad, Eyquem, Stephanie, Proto, Jonathan, Flores‐Morales, Amilcar, Pradier, Laurent
Publicado 2022

SAR228810: an antibody for protofibrillar amyloid β peptide designed to reduce the risk of amyloid-related imaging abnormalities (ARIA)

por Pradier, Laurent, Blanchard-Brégeon, Véronique, Bohme, Andrees, Debeir, Thomas, Menager, Jean, Benoit, Patrick, Barneoud, Pascal, Taupin, Véronique, Bertrand, Philippe, Dugay, Philippe, Cameron, Béatrice, Shi, Yi, Naimi, Souad, Duchesne, Marc, Gagnaire, Marie, Weeden, Tim, Travaline, Tara, Reczek, David, Khiroug, Leonard, Slaoui, Mohamed, Brunel, Pascale, Fukuyama, Hidehiro, Ravetch, Jeffrey, Canton, Thierry, Cohen, Caroline
Publicado 2018

BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr(348) phosphorylation

por Sartori, Maxime, Mendes, Tiago, Desai, Shruti, Lasorsa, Alessia, Herledan, Adrien, Malmanche, Nicolas, Mäkinen, Petra, Marttinen, Mikael, Malki, Idir, Chapuis, Julien, Flaig, Amandine, Vreulx, Anaïs-Camille, Ciancia, Marion, Amouyel, Philippe, Leroux, Florence, Déprez, Benoit, Cantrelle, François-Xavier, Maréchal, Damien, Pradier, Laurent, Hiltunen, Mikko, Landrieu, Isabelle, Kilinc, Devrim, Herault, Yann, Laporte, Jocelyn, Lambert, Jean-Charles
Publicado 2019

Tetravalent Bispecific Tandem Antibodies Improve Brain Exposure and Efficacy in an Amyloid Transgenic Mouse Model

por Do, Tuan-Minh, Capdevila, Cécile, Pradier, Laurent, Blanchard, Véronique, Lopez-Grancha, Mati, Schussler, Nathalie, Steinmetz, Anke, Beninga, Jochen, Boulay, Denis, Dugay, Philippe, Verdier, Patrick, Aubin, Nadine, Dargazanli, Gihad, Chaves, Catarina, Genet, Elisabeth, Lossouarn, Yves, Loux, Christophe, Michoux, François, Moindrot, Nicolas, Chanut, Franck, Gury, Thierry, Eyquem, Stéphanie, Valente, Delphine, Bergis, Olivier, Rao, Ercole, Lesuisse, Dominique
Publicado 2020

The FunGenES Database: A Genomics Resource for Mouse Embryonic Stem Cell Differentiation

por Schulz, Herbert, Kolde, Raivo, Adler, Priit, Aksoy, Irène, Anastassiadis, Konstantinos, Bader, Michael, Billon, Nathalie, Boeuf, Hélène, Bourillot, Pierre-Yves, Buchholz, Frank, Dani, Christian, Doss, Michael Xavier, Forrester, Lesley, Gitton, Murielle, Henrique, Domingos, Hescheler, Jürgen, Himmelbauer, Heinz, Hübner, Norbert, Karantzali, Efthimia, Kretsovali, Androniki, Lubitz, Sandra, Pradier, Laurent, Rai, Meena, Reimand, Jüri, Rolletschek, Alexandra, Sachinidis, Agapios, Savatier, Pierre, Stewart, Francis, Storm, Mike P., Trouillas, Marina, Vilo, Jaak, Welham, Melanie J., Winkler, Johannes, Wobus, Anna M., Hatzopoulos, Antonis K.
Publicado 2009