AML associated oncofusion proteins PML-RARA, AML1-ETO and CBFB-MYH11 target RUNX/ETS-factor binding sites to modulate H3ac levels and drive leukemogenesis

por Singh, Abhishek A., Mandoli, Amit, Prange, Koen H.M., Laakso, Marko, Martens, Joost H.A.
Publicado 2016

Impact of cholesterol on proinflammatory monocyte production by the bone marrow

por Stiekema, Lotte C A, Willemsen, Lisa, Kaiser, Yannick, Prange, Koen H M, Wareham, Nicholas J, Boekholdt, S Matthijs, Kuijk, Carlijn, de Winther, Menno P J, Voermans, Carlijn, Nahrendorf, Matthias, Stroes, Erik S G, Kroon, Jeffrey
Publicado 2021

Potent lipoprotein(a) lowering following apolipoprotein(a) antisense treatment reduces the pro-inflammatory activation of circulating monocytes in patients with elevated lipoprotei...

por Stiekema, Lotte C A, Prange, Koen H M, Hoogeveen, Renate M, Verweij, Simone L, Kroon, Jeffrey, Schnitzler, Johan G, Dzobo, Kim E, Cupido, Arjen J, Tsimikas, Sotirios, Stroes, Erik S G, de Winther, Menno P J, Bahjat, Mahnoush
Publicado 2020

Peritoneal macrophages have an impaired immune response in obesity which can be reversed by subsequent weight loss

por Willemsen, Lisa, Neele, Annette E, van der Velden, Saskia, Prange, Koen H M, den Toom, Myrthe, van Roomen, Cindy P A A, Reiche, Myrthe E, Griffith, Guillermo R, Gijbels, Marion J J, Lutgens, Esther, de Winther, Menno P J
Publicado 2019

Atherogenic Lipoprotein(a) Increases Vascular Glycolysis, Thereby Facilitating Inflammation and Leukocyte Extravasation

por Schnitzler, Johan G., Hoogeveen, Renate M., Ali, Lubna, Prange, Koen H.M., Waissi, Farahnaz, van Weeghel, Michel, Bachmann, Julian C., Versloot, Miranda, Borrelli, Matthew J., Yeang, Calvin, De Kleijn, Dominique P.V., Houtkooper, Riekelt H., Koschinsky, Marlys L., de Winther, Menno P.J., Groen, Albert K., Witztum, Joseph L., Tsimikas, Sotirios, Stroes, Erik S.G., Kroon, Jeffrey
Publicado 2020

Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics

por Depuydt, Marie A.C., Prange, Koen H.M., Slenders, Lotte, Örd, Tiit, Elbersen, Danny, Boltjes, Arjan, de Jager, Saskia C.A., Asselbergs, Folkert W., de Borst, Gert J., Aavik, Einari, Lönnberg, Tapio, Lutgens, Esther, Glass, Christopher K., den Ruijter, Hester M., Kaikkonen, Minna U., Bot, Ilze, Slütter, Bram, van der Laan, Sander W., Yla-Herttuala, Seppo, Mokry, Michal, Kuiper, Johan, de Winther, Menno P.J., Pasterkamp, Gerard
Publicado 2020

Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques

por Baardman, Jeroen, Verberk, Sanne G. S., van der Velden, Saskia, Gijbels, Marion J. J., van Roomen, Cindy P. P. A., Sluimer, Judith C., Broos, Jelle Y., Griffith, Guillermo R., Prange, Koen H. M., van Weeghel, Michel, Lakbir, Soufyan, Molenaar, Douwe, Meinster, Elisa, Neele, Annette E., Kooij, Gijs, de Vries, Helga E., Lutgens, Esther, Wellen, Kathryn E., de Winther, Menno P. J., Van den Bossche, Jan
Publicado 2020

Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease

por Lacy, Michael, Bürger, Christina, Shami, Annelie, Ahmadsei, Maiwand, Winkels, Holger, Nitz, Katrin, van Tiel, Claudia M., Seijkens, Tom T. P., Kusters, Pascal J. H., Karshovka, Ela, Prange, Koen H. M., Wu, Yuting, Brouns, Sanne L. N., Unterlugauer, Sigrid, Kuijpers, Marijke J. E., Reiche, Myrthe E., Steffens, Sabine, Edsfeldt, Andreas, Megens, Remco T. A., Heemskerk, Johan W. M., Goncalves, Isabel, Weber, Christian, Gerdes, Norbert, Atzler, Dorothee, Lutgens, Esther
Publicado 2021

Female Gene Networks Are Expressed in Myofibroblast-Like Smooth Muscle Cells in Vulnerable Atherosclerotic Plaques

por Diez Benavente, Ernest, Karnewar, Santosh, Buono, Michele, Mili, Eloi, Hartman, Robin J.G., Kapteijn, Daniek, Slenders, Lotte, Daniels, Mark, Aherrahrou, Redouane, Reinberger, Tobias, Mol, Barend M., de Borst, Gert J., de Kleijn, Dominique P.V., Prange, Koen H.M., Depuydt, Marie A.C., de Winther, Menno P.J., Kuiper, Johan, Björkegren, Johan L.M., Erdmann, Jeanette, Civelek, Mete, Mokry, Michal, Owens, Gary K., Pasterkamp, Gerard, den Ruijter, Hester M.
Publicado 2023

Chromatin-Based Classification of Genetically Heterogeneous AMLs into Two Distinct Subtypes with Diverse Stemness Phenotypes

por Yi, Guoqiang, Wierenga, Albertus T.J., Petraglia, Francesca, Narang, Pankaj, Janssen-Megens, Eva M., Mandoli, Amit, Merkel, Angelika, Berentsen, Kim, Kim, Bowon, Matarese, Filomena, Singh, Abhishek A., Habibi, Ehsan, Prange, Koen H.M., Mulder, André B., Jansen, Joop H., Clarke, Laura, Heath, Simon, van der Reijden, Bert A., Flicek, Paul, Yaspo, Marie-Laure, Gut, Ivo, Bock, Christoph, Schuringa, Jan Jacob, Altucci, Lucia, Vellenga, Edo, Stunnenberg, Hendrik G., Martens, Joost H.A.
Publicado 2019

Female gene networks are expressed in myofibroblast-like smooth muscle cells in vulnerable atherosclerotic plaques

por Benavente, Ernest Diez, Karnewar, Santosh, Buono, Michele, Mili, Eloi, Hartman, Robin J. G., Kapteijn, Daniek, Slenders, Lotte, Daniels, Mark, Aherrahrou, Redouane, Reinberger, Tobias, Mol, Barend M., de Borst, Gert J., de Kleijn, Dominique P. V., Prange, Koen H. M., Depuydt, Marie A. C., de Winther, Menno P. J., Kuiper, Johan, Björkegren, Johan L. M., Erdmann, Jeanette, Civelek, Mete, Mokry, Michal, Owens, Gary K, Pasterkamp, Gerard, den Ruijter, Hester M.
Publicado 2023

Intersecting single-cell transcriptomics and genome-wide association studies identifies crucial cell populations and candidate genes for atherosclerosis

por Slenders, Lotte, Landsmeer, Lennart P L, Cui, Kai, Depuydt, Marie A C, Verwer, Maarten, Mekke, Joost, Timmerman, Nathalie, van den Dungen, Noortje A M, Kuiper, Johan, de Winther, Menno P J, Prange, Koen H M, Ma, Wei Feng, Miller, Clint L, Aherrahrou, Redouane, Civelek, Mete, de Borst, Gert J, de Kleijn, Dominique P V, Asselbergs, Folkert W, den Ruijter, Hester M, Boltjes, Arjan, Pasterkamp, Gerard, van der Laan, Sander W, Mokry, Michal
Publicado 2021