1250. Novel Boronic Acid Transition State Analogs (BATSI) with in vitro inhibitory activity against class A, B and C β-lactamases

por Mojica, Maria F, Bethel, Christopher, Caselli, Emilia, Taracila, Magdalena A, Prati, Fabio, Bonomo, Robert A
Publicado 2020

Defining the minimum inhibitory concentration of 22 rifamycins in iron limited, physiologic medium against Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae clin...

por Lu, Peggy, Alletto, Francesco, Lee, Bosul, Burk, Elizabeth, Martinez, Jasmine, Prati, Fabio, Caselli, Emilia, Spellberg, Brad, Luna, Brian
Publicado 2023

High adaptability of the omega loop underlies the substrate-spectrum-extension evolution of a class A β-lactamase, PenL

por Yi, Hyojeong, Choi, Jin Myung, Hwang, Junghyun, Prati, Fabio, Cao, Thinh-Phat, Lee, Sung Haeng, Kim, Heenam Stanley
Publicado 2016

The β-Lactamase Inhibitor Boronic Acid Derivative SM23 as a New Anti-Pseudomonas aeruginosa Biofilm

por Peppoloni, Samuele, Pericolini, Eva, Colombari, Bruna, Pinetti, Diego, Cermelli, Claudio, Fini, Francesco, Prati, Fabio, Caselli, Emilia, Blasi, Elisabetta
Publicado 2020

Insights Into the Inhibition of MOX-1 β-Lactamase by S02030, a Boronic Acid Transition State Inhibitor

por Ishikawa, Tatsuya, Furukawa, Nayuta, Caselli, Emilia, Prati, Fabio, Taracila, Magdalena A., Bethel, Christopher R., Ishii, Yoshikazu, Shimizu-Ibuka, Akiko, Bonomo, Robert A.
Publicado 2021

Biochemical and Structural Analysis of Inhibitors Targeting the ADC-7 Cephalosporinase of Acinetobacter baumannii

por Powers, Rachel A., Swanson, Hollister C., Taracila, Magdalena A., Florek, Nicholas W., Romagnoli, Chiara, Caselli, Emilia, Prati, Fabio, Bonomo, Robert A., Wallar, Bradley J.
Publicado 2014

Structures of FOX-4 Cephamycinase in Complex with Transition-State Analog Inhibitors

por Lefurgy, Scott T., Caselli, Emilia, Taracila, Magdalena A., Malashkevich, Vladimir N., Biju, Beena, Papp-Wallace, Krisztina M., Bonanno, Jeffrey B., Prati, Fabio, Almo, Steven C., Bonomo, Robert A.
Publicado 2020

1,2,3-Triazolylmethaneboronate: A Structure Activity Relationship Study of a Class of β-Lactamase Inhibitors against Acinetobacter baumannii Cephalosporinase

por Caselli, Emilia, Fini, Francesco, Introvigne, Maria Luisa, Stucchi, Mattia, Taracila, Magdalena A., Fish, Erin R., Smolen, Kali A., Rather, Philip N., Powers, Rachel A., Wallar, Bradley J., Bonomo, Robert A., Prati, Fabio
Publicado 2020

Deciphering the Evolution of Cephalosporin Resistance to Ceftolozane-Tazobactam in Pseudomonas aeruginosa

por Barnes, Melissa D., Taracila, Magdalena A., Rutter, Joseph D., Bethel, Christopher R., Galdadas, Ioannis, Hujer, Andrea M., Caselli, Emilia, Prati, Fabio, Dekker, John P., Papp-Wallace, Krisztina M., Haider, Shozeb, Bonomo, Robert A.
Publicado 2018

Boronic Acid Transition State Inhibitors as Potent Inactivators of KPC and CTX-M β-Lactamases: Biochemical and Structural Analyses

por Alsenani, Tahani A., Rodríguez, María Margarita, Ghiglione, Barbara, Taracila, Magdalena A., Mojica, Maria F., Rojas, Laura J., Hujer, Andrea M., Gutkind, Gabriel, Bethel, Christopher R., Rather, Philip N., Introvigne, Maria Luisa, Prati, Fabio, Caselli, Emilia, Power, Pablo, van den Akker, Focco, Bonomo, Robert A.
Publicado 2023

Sulfonamidoboronic Acids as “Cross-Class” Inhibitors of an Expanded-Spectrum Class C Cephalosporinase, ADC-33, and a Class D Carbapenemase, OXA-24/40: Strategic Compound Design to...

por Introvigne, Maria Luisa, Beardsley, Trevor J., Fernando, Micah C., Leonard, David A., Wallar, Bradley J., Rudin, Susan D., Taracila, Magdalena A., Rather, Philip N., Colquhoun, Jennifer M., Song, Shaina, Fini, Francesco, Hujer, Kristine M., Hujer, Andrea M., Prati, Fabio, Powers, Rachel A., Bonomo, Robert A., Caselli, Emilia
Publicado 2023

Synthesis of a Novel Boronic Acid Transition State Inhibitor, MB076: A Heterocyclic Triazole Effectively Inhibits Acinetobacter-Derived Cephalosporinase Variants with an Expanded-S...

por Powers, Rachel A., June, Cynthia M., Fernando, Micah C., Fish, Erin R., Maurer, Olivia L., Baumann, Rachelle M., Beardsley, Trevor J., Taracila, Magdalena A., Rudin, Susan D., Hujer, Kristine M., Hujer, Andrea M., Santi, Nicolò, Villamil, Valentina, Introvigne, Maria Luisa, Prati, Fabio, Caselli, Emilia, Bonomo, Robert A., Wallar, Bradley J.
Publicado 2023

A comprehensive and contemporary “snapshot” of β-lactamases in carbapenem resistant Acinetobacter baumannii

por Hujer, Andrea M., Hujer, Kristine M., Leonard, David A., Powers, Rachel A., Wallar, Bradley J., Mack, Andrew R., Taracila, Magdalena A., Rather, Philip N., Higgins, Paul G., Prati, Fabio, Caselli, Emilia, Marshall, Steven H., Clarke, Thomas, Greco, Christopher, Venepally, Pratap, Brinkac, Lauren, Kreiswirth, Barry N., Fouts, Derrick E., Bonomo, Robert A.
Publicado 2021