Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis

por Shah, Ron, Shchepinov, Mikhail S., Pratt, Derek A.
Publicado 2018

Reactive Sterol Electrophiles: Mechanisms of Formation and Reactions with Proteins and Amino Acid Nucleophiles()

por Porter, Ned A., Xu, Libin, Pratt, Derek A.
Publicado 2020

The hydrogen atom transfer reactivity of sulfinic acids

por Griesser, Markus, Chauvin, Jean-Philippe R., Pratt, Derek A.
Publicado 2018

The antioxidant activity of polysulfides: it's radical!

por Chauvin, Jean-Philippe R., Griesser, Markus, Pratt, Derek A.
Publicado 2019

Inhibition of hydrocarbon autoxidation by nitroxide-catalyzed cross-dismutation of hydroperoxyl and alkylperoxyl radicals

por Harrison, Kareem A., Haidasz, Evan A., Griesser, Markus, Pratt, Derek A.
Publicado 2018

The medicinal thiosulfinates from garlic and Petiveria are not radical-trapping antioxidants in liposomes and cells, but lipophilic analogs are

por Li, Bo, Zheng, Feng, Chauvin, Jean-Philippe R., Pratt, Derek A.
Publicado 2015

Polysulfide-1-oxides react with peroxyl radicals as quickly as hindered phenolic antioxidants and do so by a surprising concerted homolytic substitution

por Chauvin, Jean-Philippe R., Haidasz, Evan A., Griesser, Markus, Pratt, Derek A.
Publicado 2016

Temperature-dependence of radical-trapping activity of phenoxazine, phenothiazine and their aza-analogues clarifies the way forward for new antioxidant design

por Poon, Jia-Fei, Farmer, Luke A., Haidasz, Evan A., Pratt, Derek A.
Publicado 2021

Dissecting the Mechanisms of a Class of Chemical Glycosylation Using Primary (13)C Kinetic Isotope Effects

por Huang, Min, Garrett, Graham E., Birlirakis, Nicolas, Bohé, Luis, Pratt, Derek A., Crich, David
Publicado 2012

Base-Promoted C–C Bond Activation Enables Radical Allylation with Homoallylic Alcohols

por Lübbesmeyer, Maximilian, Mackay, Emily G., Raycroft, Mark A. R., Elfert, Jonas, Pratt, Derek A., Studer, Armido
Publicado 2020

On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death

por Zilka, Omkar, Shah, Ron, Li, Bo, Friedmann Angeli, José Pedro, Griesser, Markus, Conrad, Marcus, Pratt, Derek A.
Publicado 2017

3-Pyridinols and 5-pyrimidinols: Tailor-made for use in synergistic radical-trapping co-antioxidant systems

por Valgimigli, Luca, Bartolomei, Daniele, Amorati, Riccardo, Haidasz, Evan, Hanthorn, Jason J, Nara, Susheel J, Brinkhorst, Johan, Pratt, Derek A
Publicado 2013

Quinone methide dimers lacking labile hydrogen atoms are surprisingly excellent radical-trapping antioxidants

por Raycroft, Mark A. R., Chauvin, Jean-Philippe R., Galliher, Matthew S., Romero, Kevin J., Stephenson, Corey R. J., Pratt, Derek A.
Publicado 2020

A Compendium of Kinetic Modulatory Profiles Identifies Ferroptosis Regulators

por Conlon, Megan, Poltorack, Carson D., Forcina, Giovanni C., Armenta, David A., Mallais, Melodie, Perez, Marcos A., Wells, Alex, Kahanu, Alexis, Magtanong, Leslie, Watts, Jennifer L., Pratt, Derek A., Dixon, Scott J.
Publicado 2021

vPIF-1 is an insulin-like antiferroptotic viral peptide

por Belavgeni, Alexia, Maremonti, Francesca, Tonnus, Wulf, Stadtmüller, Marlena, Gavali, Shubhangi, Mallais, Melodie, Flade, Karolin, Brucker, Anne, Becker, Jorunn Naila, Beer, Kristina, Tmava, Mirela, Stumpf, Julian, Gembardt, Florian, Hugo, Christian, Giacca, Mauro, Hale, Benjamin G., Perakakis, Nikolaos, Sha, Wei, Pratt, Derek A., Schally, Andrew V., Bornstein, Stefan R., Linkermann, Andreas
Publicado 2023

A non-canonical vitamin K cycle is a potent ferroptosis suppressor

por Mishima, Eikan, Ito, Junya, Wu, Zijun, Nakamura, Toshitaka, Wahida, Adam, Doll, Sebastian, Tonnus, Wulf, Nepachalovich, Palina, Eggenhofer, Elke, Aldrovandi, Maceler, Henkelmann, Bernhard, Yamada, Ken-ichi, Wanninger, Jonas, Zilka, Omkar, Sato, Emiko, Feederle, Regina, Hass, Daniela, Maida, Adriano, Mourão, André Santos Dias, Linkermann, Andreas, Geissler, Edward K., Nakagawa, Kiyotaka, Abe, Takaaki, Fedorova, Maria, Proneth, Bettina, Pratt, Derek A., Conrad, Marcus
Publicado 2022